ID | 55415 |
フルテキストURL | |
著者 |
Horihata, Kei
Laboratory of Reproductive Physiology, Faculty of Agriculture, Okayama University
Yoshioka, Shin
Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University
Sano, Masahiro
Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University
Yamamoto, Yuki
Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University
Kaken ID
researchmap
Kimura, Koji
Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University
Skarzynski, Dariusz J.
Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences
Okuda, Kiyoshi
Laboratory of Reproductive Physiology, Faculty of Agriculture, Okayama University
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抄録 | The corpus luteum (CL) synthesises and secretes progesterone (P4), which is essential for the establishment and maintenance of pregnancy in mammals. P4 is synthesised from cholesterol. Cholesterol is internalised by low-density lipoprotein receptor (LDLR) and/or scavenger receptor B1 (SR-BI), and is effluxed by ATP-binding cassette (ABC) transporter A1 (ABCA1) and G1 (ABCG1). To test the hypothesis that lipoprotein receptors and ABC transporters are involved in functional luteolysis, we examined the expression of LDLR, SR-BI, ABCA1 and ABCG1 in bovine CL during the luteal stages and after injection of prostaglandin (PG) F2α on Day 10 after ovulation. Expression of LDLR and SR-BI mRNA and protein was lower in the regressed luteal than late luteal stage. Injection of cows with a PGF2α did not affect LDLR mRNA and protein levels in the CL. Although expression of SR-BI mRNA did not change, SR-BI protein expression decreased 12 and 24 h after PGF2α injection. The overall findings of the present study suggest that the decreased expression of SR-BI induced by PGF2α is one of the factors responsible for the continuous decrease in P4 production during functional luteolysis.
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キーワード | luteal phase
ovary
progesterone
prostaglandin
reproduction
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備考 | This is an Accepted Manuscript of an article published by CSIRO Publishing
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発行日 | 2016-05-17
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出版物タイトル |
Reproduction, Fertility and Development
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巻 | 29巻
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号 | 7号
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出版者 | CSIRO Publishing
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開始ページ | 1280
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終了ページ | 1286
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ISSN | 10313613
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NCID | AA10718189
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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論文のバージョン | author
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | https://doi.org/10.1071/RD15538
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