フルテキストURL J_Orthop_Sci_22_4_731.pdf fig.pdf tbl.pdf
著者 Furumatsu, Takayuki| Fujii, Masataka| Kodama, Yuya| Ozaki, Toshifumi|
抄録 BACKGROUND: The posterior root ligament of the medial meniscus (MM) has a critical role in regulating the MM movement. An accurate diagnosis of the MM posterior root tear (MMPRT) using magnetic resonance imaging (MRI) is important for preventing sequential osteoarthritis following the MMPRT. However, diagnosis of the MMPRT is relatively difficult even after using several characteristic MRI findings. The aim of this study was to identify a useful meniscal body sign of the MMPRT for improving diagnostic MRI reading. METHODS: Eighty-five patients who underwent surgical treatments for the MMPRT (39 knees) and other types of MM tears (49 knees) were included. The presence of characteristic MRI findings such as cleft sign, ghost sign, radial tear sign, medial extrusion sign, and new meniscal body shape-oriented "giraffe neck sign" was evaluated in 120 MRI examinations. RESULTS: Giraffe neck signs were observed in 81.7% of the MMPRTs and in 3.3% of other MM tears. Cleft, ghost, and radial tear signs were highly positive in the MMPRTs compared with other MM tears. Medial extrusion signs were frequently observed in both groups. Coexistence rates of any 2 MRI signs, except for medial extrusion sign, were 91.7% in the MMPRT group and 5% in other MM tears. CONCLUSIONS: This study demonstrated that a new characteristic MRI finding "giraffe neck sign" was observed in 81.7% of the MMPRT. Our results suggest that the combination of giraffe neck, cleft, ghost, and radial tear signs may be important for an accurate diagnostic MRI reading of the MMPRT.
備考 This is an Accepted Manuscript of an article published by Elsevier
発行日 2017-07
出版物タイトル Journal of Orthopaedic Science
22巻
4号
出版者 Elsevier
開始ページ 731
終了ページ 736
ISSN 0949-2658
NCID AA11052566
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 28416188
DOI 10.1016/j.jos.2017.03.013
Web of Sience KeyUT 000407394700025
関連URL isVersionOf https://doi.org/10.1016/j.jos.2017.03.013
フルテキストURL J_Orthop_Sci_22_4_715.pdf fig.pdf
著者 Lu, Zhichao| Furumatsu, Takayuki| Fujii, Masataka| Maehara, Ami| Ozaki, Toshifumi|
抄録 BACKGROUND: The meniscus plays an important role in controlling the complex biomechanics of the knee. Meniscus injury is common in the knee joint. The perimeniscal capillary plexus supplies the outer meniscus, whereas the inner meniscus is composed of avascular tissue. Angiogenesis factors, such as vascular endothelial growth factor (VEGF), have important roles in promoting vascularization of various tissues. VEGF-mediated neovascularization is beneficial to the healing of injured tissues. However, the distribution and angiogenic role of VEGF remains unclear in the meniscus and injured meniscus. We hypothesized that VEGF could affect meniscus cells and modulate the meniscus healing process. METHODS: Menisci were obtained from total knee arthroplasty patients. Meniscal injury was created ex vivo by a microsurgical blade. VEGF mRNA and protein expression were detected by the polymerase chain reaction and immunohistochemical analyses, respectively. RESULTS: In native meniscal tissue, the expression of VEGF and HIF-1α mRNAs could not be detected. However, VEGF and HIF-1α mRNAs were found in cultured meniscal cells (VEGF: outer > inner; HIF-1α: outer = inner). Injury increased mRNA levels of both VEGF and HIF-1α, with the increase being greatest in the outer area. Immunohistochemical analyses revealed that VEGF protein was detected mainly in the outer region and around injured areas of the meniscus. However, VEGF concentrations were similar between inner and outer menisci-derived media. CONCLUSIONS: This study demonstrated that both the inner and outer regions of the meniscus contained VEGF. HIF-1α expression and VEGF deposition were high in injured meniscal tissue. Our results suggest that injury stimulates the expression of HIF-1α and VEGF that may be preserved in the extracellular matrix as the healing stimulator of damaged meniscus, especially in the outer meniscus.
キーワード vascular endothelial growth factor (VEGF) meniscus meniscal injury hypoxia-inducible factor-1α (HIF-1α)
備考 This is an Accepted Manuscript of an article published by Elsevier
発行日 2017-07
出版物タイトル Journal of Orthopaedic Science
22巻
4号
出版者 Elsevier
開始ページ 715
終了ページ 721
ISSN 0949-2658
NCID AA11052566
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 28318650
DOI 10.1016/j.jos.2017.02.006
Web of Sience KeyUT 000407394700022
関連URL isVersionOf https://doi.org/10.1016/j.jos.2017.02.006
JaLCDOI 10.18926/AMO/55439
フルテキストURL 71_5_413.pdf
著者 Furumatsu, Takayuki| Kodama, Yuya| Kamatsuki, Yusuke| Hino, Tomohito| Ozaki, Toshifumi|
抄録 Extrusion of the medial meniscus (MM) is associated with knee joint pain in osteoarthritic knees. The relationships among MM radial/oblique tears, MM extrusion (MME), and the effect of arthroscopic meniscal repair are not established. Here we evaluated the effects of arthroscopic all-inside MM repair on MME and the clinical outcomes in patients with radially oriented MM tears and mildly osteoarthritic knees. Twenty patients with a symptomatic radial or oblique tear of the MM posterior segment, MME ≥2.5 mm, and mildly osteoarthritic knees were treated using FasT-Fix 360 All-inside Meniscal Suture devices. We used magnetic resonance imaging (MRI) to measure the patients’ MM body width (MMBW), absolute MME, and relative MME. The Japanese Knee Injury and Osteoarthritis Outcome Score, Lysholm, Tegner, IKDC Subjective Knee Evaluation, and Visual Analogue Scale scores were obtained. Arthroscopic all-inside MM repair prevented increases of absolute and relative MME. The preoperative and 3- and 12-month MRI-based MMBW values were similar. Over a 24-month follow-up after the MM repairs, the clinical scores showed significant improvements. Our results suggest that all-inside meniscal repairs would be useful in preventing the progression of MME in patients suffering from symptomatic MM radial/oblique tears associated with mildly osteoarthritic knees.
キーワード medial meniscus radial/oblique tear meniscal repair meniscal extrusion osteoarthritic knee
Amo Type Original Article
発行日 2017-10
出版物タイトル Acta Medica Okayama
71巻
5号
出版者 Okayama University Medical School
開始ページ 413
終了ページ 418
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29042699
フルテキストURL J_Orthop_Sci_21_4_524.pdf fig.pdf
著者 Furumatsu, Takayuki| Maehara, Ami| Ozaki, Toshifumi|
抄録 BACKGROUND: Proper functioning of the meniscus depends on the composition and organization of its fibrocartilaginous extracellular matrix. We previously demonstrated that the avascular inner meniscus has a more chondrocytic phenotype compared with the outer meniscus. Inhibition of the Rho family GTPase ROCK, the major regulator of the actin cytoskeleton, stimulates the chondrogenic transcription factor Sry-type HMG box (SOX) 9-dependent α1(II) collagen (COL2A1) expression in inner meniscus cells. However, the crosstalk between ROCK inhibition, SOX9, and other transcription modulators on COL2A1 upregulation remains unclear in meniscus cells. The aim of this study was to investigate the role of SOX9-related transcriptional complex on COL2A1 expression under the inhibition of ROCK in human meniscus cells. METHODS: Human inner and outer meniscus cells were prepared from macroscopically intact lateral menisci. Cells were cultured in the presence or absence of ROCK inhibitor (ROCKi, Y27632). Gene expression, collagen synthesis, and nuclear translocation of SOX9 and Smad2/3 were analyzed. RESULTS: Treatment of ROCKi increased the ratio of type I/II collagen double positive cells derived from the inner meniscus. In real-time PCR analyses, expression of SOX9 and COL2A1 genes was stimulated by ROCKi treatment in inner meniscus cells. ROCKi treatment also induced nuclear translocation of SOX9 and phosphorylated Smad2/3 in immunohistological analyses. Complex formation between SOX9 and Smad3 was increased by ROCKi treatment in inner meniscus cells. Chromatin immunoprecipitation analyses revealed that association between SOX9/Smad3 transcriptional complex with the COL2A1 enhancer region was increased by ROCKi treatment. CONCLUSIONS: This study demonstrated that ROCK inhibition stimulated SOX9/Smad3-dependent COL2A1 expression through the immediate nuclear translocation of Smad3 in inner meniscus cells. Our results suggest that ROCK inhibition can stimulates type II collagen synthesis through the cooperative activation of Smad3 in inner meniscus cells. ROCKi treatment may be useful to promote the fibrochondrocytic healing of the injured inner meniscus.
備考 This is an Accepted Manuscript of an article published by Elsevier
発行日 2016-07
出版物タイトル Journal of Orthopaedic Science
21巻
4号
出版者 Elsevier
開始ページ 524
終了ページ 529
ISSN 0949-2658
NCID AA11052566
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 27113646
DOI 10.1016/j.jos.2016.02.013
Web of Sience KeyUT 000381142800020
関連URL isVersionOf https://doi.org/10.1016/j.jos.2016.02.013
タイトル(別表記) Japanese guidelines for the treatment of hip fractures in the elderly
フルテキストURL 122_253.pdf
著者 野田 知之| 尾﨑 敏文|
備考 整形外科シリーズ ガイドライン (Guideline Orthopaedic surgery)
出版物タイトル 岡山医学会雑誌
発行日 2010-12-01
122巻
3号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 253
終了ページ 257
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
言語 Japanese
著作権者 Copyright (c) 2010 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.122.253
NAID 130004903185
Sort Key 12
Eprints Journal Name joma
参考文献 1) 日本整形外科学会診療ガイドライン委員会, 大腿骨頚部/転子部骨折ガイドライン策定委員会 : 大腿骨頚部/転子部骨折診療ガイドライン. 南江堂, 東京(2005). 2) 折茂 肇, 坂田清美 : 第四回大腿骨頸部骨折全国頻度調査成績2002年における新発生患者数の推定と15年間の推移. 日本医事新報(2004)25-30. 3) Garden RS : Low-angle fixation in fractures of the femoral neck. J Bone Joint Surg Br (1961) 43B, 647-663. 4) Jensen JS : Classification of trochanteric fractures. Acta Orthop Scand (1980) 51, 803-810. 5) Evans EM : The Treatment of Trochanteric Fractures of the Femur. J Bone Joint Surg Br (1949) 31B, 190-203. 6) Fracture and dislocation compendium. Orthopaedic Trauma Association Committee for Coding and Classification. J Orthop Trauma (1996) 10, 31-35.
JaLCDOI 10.18926/AMO/32654
フルテキストURL fulltext.pdf
著者 Ozaki, Toshifumi| Inoue, Hajime| Sugihara, Shinsuke| Sumii, Hiroshi|
抄録 <p>Radiological findings on the fate of grafted Kiel bone implants for the treatment of bone tumors were evaluated in 25 lesions. The mean follow-up period was 14.8 years, ranging from 5 to 21.8 years. We classified the radiological findings into 4 grades; Excellent (4 lesions), Good (14 lesions), Fair (2 lesions), and Poor (5 lesions). All cases of the Poor grade were polyostotic fibrous dysplasia. The younger the patient at the time of the operation, the more rapidly Kiel bone grafts tended to be incorporated. The grafted bone can become enmeshed in the structure of the recipient bed (Good or Excellent grades) within 10 years in most cases, except in polyostotic fibrous dysplasia.</p>
キーワード xenogeneic bone bone grafting bone neoplasms
Amo Type Article
発行日 1992-04
出版物タイトル Acta Medica Okayama
46巻
2号
出版者 Okayama University Medical School
開始ページ 87
終了ページ 92
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1575062
Web of Sience KeyUT A1992HR48400005
JaLCDOI 10.18926/AMO/32641
フルテキストURL fulltext.pdf
著者 Ozaki, Toshifumi| Inoue, Hajime| Taguchi, Kohji| Sugihara, Shinsuke|
抄録 <p>We compared gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) enhanced T1-weighted images (T1-Gd) with the histopathological findings in 13 patients with bone or soft tissue sarcomas. Signal intensity of the viable tumor tissue was increased in T1-Gd in 92% of the patients. The necrotic or cystic areas in the tumor were not enhanced, rendering them distinctly. The degree of enhancement of the edematous area around the tumor was similar to or more marked than that of the tumor in 54% of the patients. Area showing inflammatory cells infiltration and edematous areas in the tumor tissue were also enhanced. Thus, the effect of preoperative chemotherapy in tumor tissues other than necrotic and cystic areas tended to be underestimated in T1-Gd. Its effect should be comprehensively evaluated based on not only T1-Gd but also T2-weighted images and findings of other imaging techniques.</p>
キーワード gadolinium diethylenetriaminepentaacetic acid(DTPA) magnetic resonance(MR) bone neoplasms soft tissue neoplasms
Amo Type Article
発行日 1992-12
出版物タイトル Acta Medica Okayama
46巻
6号
出版者 Okayama University Medical School
開始ページ 471
終了ページ 477
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1485542
Web of Sience KeyUT A1992KE49600010
JaLCDOI 10.18926/AMO/32621
フルテキストURL fulltext.pdf
著者 Ozaki, Toshifumi| Inoue, Hajime| Sugihara, Shinsuke|
抄録 <p>We evaluated the surgical problems encountered during treatment of 14 patients with malignant tumors originating in the pelvic region at our department. The tumor involved the iliac bone in 6 patients, the ischial bone in 2, the pubic bone in 2, and the gluteal region in 4. Invasion to the sacrum was observed in 7 patients. Twelve patients underwent surgical procedures consisting of intralesional resection in 6, marginal resection in 3, and wide margin resection in 3. Six of the 7 patients with sacral invasion developed local recurrence. Two patients with chondrosarcoma and one with parosteal osteosarcoma survived for 4 or more years, but the mean survival period in those with high grade malignant tumors was 11 months. These findings indicate the difficulties encountered in the treatment of malignant pelvic tumors.</p>
キーワード bone neoplasms soft tissue neoplasms malignant neoplasms pelvis surgical treatment
Amo Type Article
発行日 1992-08
出版物タイトル Acta Medica Okayama
46巻
4号
出版者 Okayama University Medical School
開始ページ 265
終了ページ 271
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1442150
Web of Sience KeyUT A1992JL44200006
JaLCDOI 10.18926/AMO/31575
フルテキストURL fulltext.pdf
著者 Ozaki, Toshifumi| Sugihara, Shinsuke| Inoue, Hajime|
抄録 <p>We report second malignant neoplasms which developed between 7 and 19 years after treatment in 3 pediatric patients with osteosarcoma. Two patients had been treated with only surgery, and another patient had been treated with a combination of surgery with chemotherapy and radiation therapy for primary lesions. Pediatric patients with osteosarcoma, in particular, require careful long-term follow-up to monitor not only metastases but also development of second malignant neoplasms.</p>
キーワード osteosarcoma second malignancy
Amo Type Article
発行日 1993-04
出版物タイトル Acta Medica Okayama
47巻
2号
出版者 Okayama University Medical School
開始ページ 129
終了ページ 133
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8506750
Web of Sience KeyUT A1993LA45200010
JaLCDOI 10.18926/AMO/31340
フルテキストURL fulltext.pdf
著者 Ozaki, Toshifumi| Nakatsuka, Yoichi| Kawai, Akira| Akazawa, Hirofumi| Kunisada, Toshiyuki| Inoue, Hajime|
抄録 <p>There are few reports on skeletal reconstruction using the bone transport technique to repair bone defects caused by resections of tumors associated with osteosarcoma. We attempted to reconstruct a 23 cm bone defect after resection of an osteosarcoma of the left femur, and succeeded in gaining 17 cm by bone transport. Five years after surgery, this patient remains alive without metastasis or local recurrence.</p>
キーワード osteosarcoma bone transport reconstruction
Amo Type Article
発行日 1998-02
出版物タイトル Acta Medica Okayama
52巻
1号
出版者 Okayama University Medical School
開始ページ 67
終了ページ 70
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9548997
Web of Sience KeyUT 000072264100010
JaLCDOI 10.18926/AMO/31335
フルテキストURL fulltext.pdf
著者 Ozaki, Toshifumi| Nakatsuka, Yoichi| Kawai, Akira| Akazawa, Hirofumi| Kunisada, Toshiyuki| Inoue, Hajime|
抄録 <p>There are few reports on skeletal reconstruction using the bone transport technique to repair bone defects caused by resections of tumors associated with osteosarcoma. We attempted to reconstruct a 23 cm bone defect after resection of an osteosarcoma of the left femur, and succeeded in gaining 17 cm by bone transport. Five years after surgery, this patient remains alive without metastasis or local recurrence.</p>
キーワード osteosarcoma bone transport reconstruction
Amo Type Article
発行日 1998-02
出版物タイトル Acta Medica Okayama
52巻
1号
出版者 Okayama University Medical School
開始ページ 67
終了ページ 70
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9548997
Web of Sience KeyUT 000072264100010
JaLCDOI 10.18926/AMO/30784
フルテキストURL fulltext.pdf
著者 Kunisada, Toshiyuki| Kawai, Akira| Ozaki, Toshifumi| Sugihara, Shinsuke| Taguchi, Kohji| Inoue, Hajime|
抄録 <p>In this study, we reviewed the clinical features of 11 patients with malignant schwannoma who were treated in our institute. Five patients had coexistent von Recklinghausen's disease and one of them showed multifocal occurrence. Patients with the centrally located tumors had a poorer prognosis than those with the others. The overall 3-year survival rate was 36%; 40% in patients with von Recklinghausen's disease and 33% in the others. At the time of the last follow-up, 9 patients had died of the tumor, one continued to be tumor free, and one was alive with tumor. Postoperative local recurrence developed in 5 patients (45%); 4 out of 6 patients (67%) who underwent a marginal excision and one out of 3 (33%) who underwent primary amputation. There was no local recurrence in patients after a wide excision with at least 3cm of normal tissue removed surrounding the tumor in all directions. Nine patients (82%) developed pulmonary metastasis. The effect of adjuvant chemotherapy was not clear in this study. The high risk of pulmonary metastasis in this disease indicates the necessity of more effective adjuvant chemotherapy.</p>
キーワード malignant schwannoma clinical analysis von Recklinghausen's disease
Amo Type Article
発行日 1997-04
出版物タイトル Acta Medica Okayama
51巻
2号
出版者 Okayama University Medical School
開始ページ 87
終了ページ 92
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9142345
Web of Sience KeyUT A1997WX19600005
JaLCDOI 10.18926/AMO/30776
フルテキストURL fulltext.pdf
著者 Makihata, Eiichi| Kuroda, Masahiro| Kawai, Akira| Ozaki, Toshifumi| Sugihara, Shinsuke| Inoue, Hajime| Joja, Ikuo| Asaumi, Junichi| Kawasaki, Shoji| Hiraki, Yoshio|
抄録 <p>We report the results of phase I/II studies of preoperative multidisciplinary treatment of 14 patients with soft tissue sarcoma using hyperthermia from November 1990 to April 1995. The preoperative treatment was conducted with thermo-radio-chemotherapy in 11 cases of stage III, and with thermo-radiotherapy as well as thermo-chemotherapy in three cases of stages I and II. Hyperthermia was carried out twice a week with totals ranging from 4 to 14 times (average: 8.4 times); each session lasted 60min. Radiotherapy was administered four or five times per week, and the dose was 1.8 2Gy/fraction, with a total of 30-40Gy in a four week period. Chemotherapy was mainly in the form of MAID regimen (2-mercaptoethanesulphonic acid (mesna), adriamycin, ifosfamide and dacarbazine). The tumors were surgically resected in all patients after completing the preoperative treatment. The efficacy rate, as expressed by the percentage of either tumors in which reduction rate was 50% or more, or tumors for which post-treatment contrast enhanced CT image revealed low density volumes occupying 50% or more of the total mass, was 71 % (ten of the 14 tumors). The mean tumor necrosis rate in the resected specimens was 78%. The tumor necrosis rate was significantly high (P &#60; 0.05) in patients whose Time &#8805; 42°C was of long duration. Postoperative complications were observed in six patients; among these, two patients developed wound infection that required surgical treatment as a complication of surgery performed in the early stage following the preoperative treatment. After a mean postoperative follow-up of 27 months, distant metastasis occurred in four patients resulting in three fatalities. The three-year cumulative survival rate was 64.3%. No local recurrence was observed in any patient during the follow-up, thus confirming our hypothesis that preoperative multidisciplinary treatment has an excellent local efficacy. We think that it would be valuable to conduct, at many facilities, phase III studies on the treatment of soft tissue sarcoma by a combination of surgery and preoperative multidisciplinary treatment using hyperthermia, paying close attention to the interval between these two modalities.</p>
キーワード soft tissue tumor hyperthermia radiotherapy chemotherapy
Amo Type Article
発行日 1997-04
出版物タイトル Acta Medica Okayama
51巻
2号
出版者 Okayama University Medical School
開始ページ 93
終了ページ 99
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9142346
Web of Sience KeyUT A1997WX19600006
JaLCDOI 10.18926/AMO/32889
フルテキストURL fulltext.pdf
著者 Nakanishi, Kazuo| Tanaka, Masato| Sugimoto, Yoshihisa| Ozaki, Toshifumi|
抄録 <p>We performed fixation using laminar screws in 2 patients in whom lateral mass screws, pedicle screws or transarticular screws could not be inserted. One was a 56-year-old woman who had anterior atlantoaxial subluxation (AAS). When a guide wire was inserted using an imaging guide, the hole bled massively. We thought the re-insertion of a guide wire or screw would thus increase the risk of vascular injury, so we used laminar screws. The other case was an 18-year-old man who had a hangman fracture. Preoperative magnetic resonance angiography showed occlusion of the left vertebral artery. A laminar screw was inserted into the patent side (i.e., the right side of C2). Cervical pedicle screws are the most biomechanically stable screws. However, their use carries a high risk of neurovascular complications during screw insertion, because the cervical pedicle is small and is adjacent laterally to the vertebral artery, medially to the spinal cord, and vertically to the nerve roots. Lateral mass screws are also reported to involve a risk of neurovascular injuries. The laminar screw method was thus thought to be useful, since arterial injuries could thus be avoided and it could also be used as a salvage modality for the previous misinsertion.</p>
キーワード laminar screw neurovascular complications lateral mass screw pedicle screw transarticular
Amo Type Case Report
発行日 2007-04
出版物タイトル Acta Medica Okayama
61巻
2号
出版者 Okayama University Medical School
開始ページ 115
終了ページ 119
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17471313
Web of Sience KeyUT 000245875600010
JaLCDOI 10.18926/AMO/30758
フルテキストURL fulltext.pdf
著者 Tanaka, Masato| Nakahara, Shinnosuke| Ito, Yauo| Nakanishi, Kazuo| Sugimoto, Yoshihisa| Ikuma, Hisanori| Ozaki, Toshifumi|
抄録 <p>The purpose of this study was to investigate the surgical outcomes and to determine indicators of the necessity of surgical intervention. Twelve consecutive patients harboring symptomatic sacral perineural cysts were treated between 1995 and 2003. All patients were assessed for neurological deficits and pain by neurological examination. Magnetic resonance of imaging, computerized tomography, and myelography were performed to detect signs of delayed filling of the cysts. We performed a release of the valve and imbrication of the sacral cysts with laminectomies in 8 cases or recapping laminectomies in 4 cases. After surgery, symptoms improved in 10 (83%) of 12 patients, with an average follow-up of 27 months. Ten patients had sacral perineural cysts with signs of positive filling defect. Two (17%) of 12 patients experienced no significant improvement. In one of these patients, the filling defect was negative. In conclusion, a positive filling defect may become an indicator of good treatment outcomes.</p>
キーワード Tarlov cyst sacral perineural cyst meningeal cyst meningeal diverticulum sacral radiculopathy
Amo Type Article
発行日 2006-02
出版物タイトル Acta Medica Okayama
60巻
1号
出版者 Okayama University Medical School
開始ページ 65
終了ページ 70
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 16508691
Web of Sience KeyUT 000235538900008
JaLCDOI 10.18926/AMO/30749
フルテキストURL fulltext.pdf
著者 Komiyama, Takamitsu| Nishida, Keiichiro| Yorimitsu, Masanori| Doi, Hideyuki| Miyazawa, Shinichi| Kitamura, Ai| Yoshida, Aki| Nasu, Yoshihisa| Abe, Nobuhiro| Ozaki, Toshifumi|
抄録 Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in SHR relevant to the ossification disturbance and osteonecrosis of the femoral head. Serum levels of IGF-1 and VEGF were significantly lower in SHR than in Wistar Kyoto rats (WKY) at weeks 5, 10, 15 and 20 (p&#60;0.005). The incidence of histological ossification disturbance of the femoral head was higher in SHR (59%) than in WKY (40%) at week 20. Lower serum and local levels of VEGF in SHR appeared to be related to the incomplete ossification of the femoral heads. Immunohistochemical study showed significantly lower numbers of IGF-1 and VEGF positive chondrocytes in the femoral epiphyseal cartilage of SHR than in those of WKY at weeks 10, 15 and 20. Our results suggest that local and/or systemic levels of IGF-1 and VEGF between ages of 5 and 20 weeks might play roles in the pathogenesis of ossifi cation disturbance of the femoral head in SHR.
キーワード spontaneous hypertensive rats insulin like growth factor-1 vascular endothelial growth factor ossification disturbance osteonecrosis
Amo Type Article
発行日 2006-06
出版物タイトル Acta Medica Okayama
60巻
3号
出版者 Okayama University Medical School
開始ページ 141
終了ページ 148
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 16838042
Web of Sience KeyUT 000238503600001
JaLCDOI 10.18926/AMO/30739
フルテキストURL fulltext.pdf
著者 Aiga, Ayako| Asaumi, Koji| Lee, You Jin| Kadota, Hiroaki| Mitani, Shigeru| Ozaki, Toshifumi| Takigawa, Masaharu|
抄録 The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation. After osteotomy, a 7-day lag phase was followed by distraction at the rate of 0.25 mm/12 h for 21 days (distraction phase), and a 7-day consolidation phase. The localization of neurotrophins (NGF, BDNF and NT-3) and their receptors tropomyosinrelated kinases (TRKA, TRKB and TRKC) by immunostaining showed positive staining in bone forming cells in each stage, although the presence and staining intensity varied by cell type and phase. The expressions of NGF, BDNF and NT-3 by real-time polymerase chain reaction (real-time PCR) showed that the peak of the mRNA expression of NGF occurred 10 days after distraction. NT-3 increased during bone extension, but decreased when distraction stopped. In contrast, BDNF continued to increase gradually throughout the distraction and consolidation phases. These findings suggest that neurotrophins and their receptors may play different roles in endochondral and intramembranous ossification in distraction osteogenesis. The tension stress caused by distraction may stimulate the expression of neurotrophins and their receptors, and promote osteogenesis.
キーワード neurotrophin Trk distraction osteogenesis mechanical stress
Amo Type Article
発行日 2006-10
出版物タイトル Acta Medica Okayama
60巻
5号
出版者 Okayama University Medical School
開始ページ 267
終了ページ 277
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17072373
Web of Sience KeyUT 000241509000003
JaLCDOI 10.18926/AMO/30721
フルテキストURL fulltext.pdf
著者 Inoue, Atsushi| Asaumi, Koji| Endo, Hirosuke| Fujiwara, Kazuo| Mitani, Shigeru| Ozaki, Toshifumi|
抄録 The present retrospective study assessed radiographs to determine socket wear in total hip arthroplasty (THA) with 22-mm zirconia or COP (Cobalt-Chrome alloy rich in Cobalt and Phosphorous) heads, and in cemented stems at more than 10 years after operation. Sockets of ultra high molecular weight polyethylene were used in each of two THA groups (13 hips each) in a clinical trial in our hospital between 1989 and 1990. Three observers carried out masked assessments of the radiographs. Upon fi nal examination, there was no remarkable loosening in the zirconia or COP group, and no case had required revision surgery as of 2005. There was a statistically signifi cant diff erence between the 2 groups in average annual linear wear, at 0.093 mm/year and 0.046 mm/year in the zirconia and COP groups, respectively. Volume wear and average annual volume wear were also signifi cantly greater in the zirconia group despite its superior mechanical strength and toughness in vitro. Our present fi ndings do not confi rm early expectations of lower wear in long-term results of 22-mm zirconia femoral heads used in THA.
キーワード total hip arthroplasty zirconia head COP head polyethylene wear
Amo Type Original Article
発行日 2006-12
出版物タイトル Acta Medica Okayama
60巻
6号
出版者 Okayama University Medical School
開始ページ 311
終了ページ 318
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17189974
Web of Sience KeyUT 000243019000002
JaLCDOI 10.18926/AMO/55312
フルテキストURL 71_4_345.pdf
著者 Tanaka, Masato| Sugimoto, Yoshihisa| Takigawa, Tomoyuki| Kimata, Yoshihiro| Ozaki, Toshifumi|
抄録 Osteoradionecrosis (ORN), a well-known complication of radiotherapy in the mandibular bone, is very rare in the cervical spine. The authors report the result of a 3-year follow-up of a 63-year-old female patient with ORN of the cervical spine. The patient had a history of laryngeal carcinoma and was treated with chemotherapy and radiation therapy with a total of 120 Gy. Eight years later, she developed acute, severe neck pain due to cervical spine necrosis. The authors performed vascularized fibular bone graft and posterior pedicle screw fixation to reconstruct her cervical spine. The patient was successfully treated with surgery, and cervical alignment was preserved. She had neither neurological deficits nor severe neck pain at her final follow-up 3 years later. Delaying treatment of ORN may be life threatening, so the early diagnosis of this condition is important for patients who receive radiotherapy. Otolaryngologists and spine surgeons should understand this potential complication to speed diagnosis and treatment as early as possible.
キーワード osteoradionecrosis laryngeal carcinoma cervical spine radiotherapy
Amo Type Case Report
発行日 2017-08
出版物タイトル Acta Medica Okayama
71巻
4号
出版者 Okayama University Medical School
開始ページ 345
終了ページ 349
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28824191
JaLCDOI 10.18926/AMO/55308
フルテキストURL 71_4_315.pdf
著者 Fujii, Yosuke| Endo, Hirosuke| Mitani, Shigeru| Akazawa, Hirofumi| Tetsunaga, Tomonori| Miyake, Takamasa| Yamada, Kazuki| Aoki, Kiyoshi| Ozaki, Toshifumi|
抄録 We retrospectively reviewed 29 hips in which intertrochanteric osteotomies were performed for severe slipped capital femoral epiphyses. Mean age at surgery: 12.6 years. Mean follow-up period: 6 years. At the final follow-up evaluation, one patient had coxalgia, and six hips showed a limited range of motion. A pistol-grip deformity was observed in 13 hips, osteoarthritis in two hips, and a bump existed in 19 hips on the latest radiographs. Gradual remodeling of the bumps was observed post-operatively in 22 hips. The mean α and β angles and offset α and β improved over time. The remodeling proceeded rapidly for 1 year post-surgery. We compared hips classified as β angles of ≥ 63° to < 63° at the final follow-up evaluation, the mean β angle 1 year post-surgery, and the mean ratio of improvement of the β angle per year from 1 year post-surgery to the final follow up, which differed significantly. Nearly all of the patients who underwent intertrochanteric osteotomies had residual morphologic abnormalities, but few had clinical symptoms. The β angle 1 year post-surgery and the ratio of remodeling of the bump from 1 year post-surgery to the final follow-up can be regarded as a potential predictor of morphologic results after intertrochanteric osteotomy.
キーワード slipped capital femoral epiphyses intertrochanteric osteotomy residual femoral deformity femoroacetabular impingement bone remodeling
Amo Type Original Article
発行日 2017-08
出版物タイトル Acta Medica Okayama
71巻
4号
出版者 Okayama University Medical School
開始ページ 315
終了ページ 323
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28824187