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ID 53518
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著者
座間味 義人 岡山大学大学院医歯薬学総合研究科臨床薬学分野
高取 真吾 日本新薬創薬研究所
合田 光寛 岡山大学大学院医歯薬学総合研究科臨床薬学分野
小山 敏広 岡山大学大学院医歯薬学総合研究科臨床薬学分野
岩谷 有希子 岡山大学大学院医歯薬学総合研究科臨床薬学分野
Jin, Xin 岡山大学大学院医歯薬学総合研究科臨床薬学分野
Takada-Doi, Shima 山田養蜂場本社研究開発部
川﨑 博己 岡山大学大学院医歯薬学総合研究科臨床薬学分野
抄録
Royal jelly (RJ) is known to contain excellent nutrition and a variety of biological activities. The present study was designed to investigate the effects of RJ on insulin resistance (hyperinsulinemia) in fructose-drinking rats (FDR; insulin resistance animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin and triglyceride, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), and systolic blood pressure, but not blood glucose levels, when compared with control rats. RJ (100, 300mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma levels of insulin and triglyceride, HOMA-R, without affecting blood glucose or total cholesterol levels and tended to lower systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, RJ treatment resulted in a significant reduction in sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase the calcitonin gene-related peptide (CGRP) nervemediated vasodilator response to PNS, compared with those in untreated FDR. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction or CGRP-induced vasodilation. These results suggest that RJ could be an effective functional food to prevent insulin resistance associated with the development of hypertension.
キーワード
royal jelly
fructose-drinking rat
insulin resistance
periarterial nerve function
備考
コンテンツの著作権は日本薬学会が有します。
発行日
2008-11-01
出版物タイトル
Biological & Pharmaceutical Bulletin
31巻
11号
出版者
日本薬学会
出版者(別表記)
The Pharmaceutical Society of Japan
開始ページ
2103
終了ページ
2107
ISSN
09186158
NCID
AA10885497
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© The Pharmaceutical Society of Japan
論文のバージョン
publisher
査読
有り
DOI
PubMed ID
Web of Sience KeyUT