ID | 47009 |
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著者 |
Miyoshi, Ko
Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Kasahara, Kyosuke
Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Miyazaki, Ikuko
Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
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publons
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Asanuma, Masato
Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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抄録 | Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies. Recent studies have demonstrated that some pharmacological agents and extracellular environmental changes can alter primary cilium length. Renal injury is a well-known example of an environmental insult that triggers cilia length modification. Lithium treatment causes primary cilia to extend in several cell types including neuronal cells;this phenomenon is likely independent of glycogen synthase kinase-3β inhibition. In renal epithelial cell lines, deflection of the primary cilia by fluid shear shortens them by reducing the intracellular cyclic AMP level, leading to a subsequent decrease in mechanosensitivity to fluid shear. Primary cilium length is also influenced by the dynamics of actin filaments and microtubules through the levels of soluble tubulin in the cytosol available for primary cilia extension. Thus, mammalian cells can adapt to the extracellular environment by modulating the primary cilium length, and this feedback system utilizing primary cilia might exist throughout the mammalian body. Further investigation is required concerning the precise molecular mechanisms underlying the control of primary cilium length in response to environmental factors.
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キーワード | primary cilium length
lithium
cyclic AMP
soluble tubulin
intraflagellar transport
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Amo Type | Review
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2011-10
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巻 | 65巻
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号 | 5号
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出版者 | Okayama University Medical School
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開始ページ | 279
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終了ページ | 285
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2011 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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