JaLCDOI 10.18926/AMO/53521
フルテキストURL 69_3_145.pdf
著者 Ishii, Hiroko| Kamikawa, Shigeshi| Hirohata, Satoshi| Mizutani, Akifumi| Abe, Koji| Seno, Masaharu| Oohashi, Toshitaka| Ninomiya, Yoshifumi|
抄録 Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis.
キーワード ECP reactive oxygen species Akt ERK
Amo Type Original Article
発行日 2015-06
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 145
終了ページ 153
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26101190
Web of Science KeyUT 000356903000003
タイトル(別表記) Role of COLXV/XVⅢ gene, Multiplexin, as a basement membrane toolkit
フルテキストURL 127_103.pdf
著者 大橋 俊孝|
キーワード 基底膜 ツールキット XV/XVⅢ型コラーゲン プロテオグリカン ミトコンドリア
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
開始ページ 103
終了ページ 109
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.103
言語 Japanese
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.103
NAID 130005096251