ID | 60246 |
フルテキストURL | |
著者 |
Yamamoto, Haruchika
Department of General Thoracic Surgery, Okayama University Hospital
Sugimoto, Seiichiro
Department of General Thoracic Surgery, Okayama University Hospital
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Kurosaki, Takeshi
Department of Organ Transplant Center, Okayama University Hospital
Kaken ID
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Miyoshi, Kentaroh
Department of Organ Transplant Center, Okayama University Hospital
Kaken ID
Otani, Shinji
Department of General Thoracic Surgery, Okayama University Hospital
Okazaki, Mikio
Department of General Thoracic Surgery, Okayama University Hospital
Yamane, Masaomi
Department of General Thoracic Surgery, Okayama University Hospital
Kaken ID
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Toyooka, Shinichi
Department of General Thoracic Surgery, Okayama University Hospital
ORCID
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抄録 | Because chronic lung allograft dysfunction (CLAD) develops predominantly on one side after bilateral living-donor lobar lung transplantation (LDLLT), lung perfusion scintigraphy (Q-scinti) was expected to show a perfusion shift to the contralateral unaffected lung with the development of CLAD. Our study examined the potential usefulness of Q-scinti in the diagnosis of CLAD after bilateral LDLLT. We conducted a single-center retrospective cohort study of 58 recipients of bilateral LDLLT. The unilateral shift values on Q-scinti were calculated and compared between the CLAD group (N=27) and the non-CLAD group (N=31) from 5 years before to 5 years after the diagnosis of CLAD. The unilateral shift values in Q-scinti were significantly higher in the CLAD group than in the non-CLAD group from 5 years before the diagnosis of CLAD to 5 years after the diagnosis (P<0.05). The unilateral shift values in Q-scinti were significantly correlated with the percent baseline values of the forced expiratory volume in 1 s (P=0.0037), the total lung capacity (P=0.0028), and the forced vital capacity (P=0.00024) at the diagnosis of CLAD. In patients developing unilateral CLAD after bilateral LDLLT, Q-scinti showed a unilateral perfusion shift to the contralateral unaffected lung. Thus, Q-scinti appears to have the potential to predict unilateral CLAD after bilateral LDLLT.
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発行日 | 2020-06-29
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出版物タイトル |
Scientific Reports
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巻 | 10巻
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号 | 1号
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出版者 | Nature
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開始ページ | 10595
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ISSN | 2045-2322
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © The Author(s) 2020
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1038/s41598-020-67433-4
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ライセンス | http://creat iveco mmons .org/licen ses/by/4.0/
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助成機関名 |
文部科学省
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助成番号 | 19K09305
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