JaLCDOI 10.18926/AMO/54988
フルテキストURL 71_2_181.pdf
著者 Hayata, Kei| Hiramatsu, Yuji| Masuyama, Hisashi| Eto, Eriko| Mitsui, Takashi| Tamada, Shoko|
抄録 We experienced a case of advanced maternal age in which a fetus was found to be positive for trisomy 18 at re-examination following indeterminate non-invasive prenatal genetic testing (NIPT), the amniotic fluid chromosomal test revealed a normal karyotype, and confined placental mosaicism (CPM) was observed in an SNP microarray analysis of the placenta. The child was born with no defects or complications. In the present case, the result of the original NIPT at week 15 of pregnancy was indeterminate and the subsequent re-examination result was positive; since the definitive normal diagnosis was not reported until the latter half of week 21, the pregnant patient was subjected to psychological stress for a long period of time. The problem with NIPT is that most of the fetus-derived cell-free DNA in the maternal blood is not derived directly from the fetus but from the villus cells of the placenta, leading to indefinite diagnoses; for that reason, the pregnant patient was subjected to psychological stress for a long period of time. Of the 18,251 cases undergoing NIPT in the past 2 years in Japan, 51 had indeterminate results; this was the second case in which a subsequent re-examination gave a positive result for trisomy 18.
キーワード non-invasive prenatal genetic testing massively parallel sequencing confined placental mosaicism genetic counseling trisomy 18
Amo Type Case Report
発行日 2017-04
出版物タイトル Acta Medica Okayama
71巻
2号
出版者 Okayama University Medical School
開始ページ 181
終了ページ 185
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol71/iss2/13
PubMed ID 28420901
JaLCDOI 10.18926/AMO/54985
フルテキストURL 71_2_161.pdf
著者 Nobumoto, Etsuko| Masuyama, Hisashi| Maki, Jota| Eguchi, Takeshi| Tamada, Shoko| Mitsui, Takashi| Eto, Eriko| Hayata, Kei| Hiramatsu, Yuji|
抄録 Although gestational hypertension (GH) is thought to be different from preeclampsia (PE), in Japan GH and PE are usually treated as the same disease (i.e., pregnancy-induced hypertension). Here we sought to determine whether there are any differences in fetal growth and maternal kidney function between pregnancies with PE and those with GH. We retrospectively analyzed 61 GH patients and 60 PE patients with singleton pregnancies who delivered at Okayama University Hospital (2008-2015). We compared maternal and perinatal outcomes and maternal kidney function parameters between the GH and PE pregnancies. The mean values of maternal age (p=0.01), gestational age at delivery (p<0.0001), placental weight (p=0.002), birth weight and height (p<0.0001, p=0.0001), and head circumference standard deviation score (p=0.007) of newborns of the GH group were significantly higher than those of the PE group. The duration until termination of PE or GH was not significantly correlated with kidney function. The birth weight percentile was significantly correlated with kidney function in PE but not GH. However, GH patients with poor kidney function and small-for-gestational age infants showed perinatal outcomes similar to those of the PE group. Monitoring kidney function is thus important for determining the severity of PE and GH.
キーワード preeclampsia gestational hypertension perinatal outcome kidney function fetal growth
Amo Type Original Article
発行日 2017-04
出版物タイトル Acta Medica Okayama
71巻
2号
出版者 Okayama University Medical School
開始ページ 161
終了ページ 169
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol71/iss2/10
PubMed ID 28420898
著者 Masuyama, Hisashi| Nobumoto, Etsuko| Segawa, Tomonori| Hiramatsu, Yuji|
発行日 2012-04
出版物タイトル Acta Medica Okayama
66巻
2号
資料タイプ 学術雑誌論文
著者 Masumoto, Akio| Masuyama, Hisashi| Takamoto, Norio| Akahori, Yoichiro| Hiramatsu, Yuji|
発行日 2010-08
出版物タイトル Acta Medica Okayama
64巻
4号
資料タイプ 学術雑誌論文
著者 Akahori, Yoichiro| Takamoto, Norio| Masumoto, Akio| Inoue, Seiji| Nakatsukasa, Hideki| Masuyama, Hisashi| Hiramatsu, Yuji|
発行日 2010-04
出版物タイトル Acta Medica Okayama
64巻
2号
資料タイプ 学術雑誌論文
著者 Kumazawa, Kazumasa| Hiramatsu, Yuji| Masuyama, Hisashi| Mizutani, Yasushi| Nakata, Takakimi| Kudo, Takafumi|
発行日 2003-02
出版物タイトル Acta Medica Okayama
57巻
1号
資料タイプ 学術雑誌論文
著者 Hiramatsu, Yuji| Masuyama, Hisashi| Ishida, Makoto| Murakami, Kazuharu| Sakurai, Masaru|
発行日 2005-10
出版物タイトル Acta Medica Okayama
59巻
5号
資料タイプ 学術雑誌論文
著者 増山 寿|
発行日 2006-01-04
出版物タイトル 岡山医学会雑誌
117巻
3号
資料タイプ 学術雑誌論文
著者 増山 寿|
発行日 2005-01-31
出版物タイトル 岡山医学会雑誌
116巻
3号
資料タイプ 学術雑誌論文
著者 増山 寿|
発行日 1995-03-31
出版物タイトル
資料タイプ 学位論文