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ID 31834
JaLCDOI
フルテキストURL
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著者
Munemasa, Mitsuru Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yoshino, Tadashi Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
Kobayashi, Keita Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Miyake, Takayoshi Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Sakugawa, Sumie Takase Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Mannami, Tomohiko Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Shinagawa, Katsuji Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tanimoto, Mitsune Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
Akagi, Tadaatsu Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録

Reportedly, thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Hashimoto's thyroiditis. However, it remains unknown which antigen is closely associated with thyroid MALT lymphoma. We examined whether B cell response to thyroglobulin (Tg), which is a common thyroid-specific autoantigen, is related etiologically to the pathogenesis of thyroid MALT lymphoma. Expression of human Tg antigens and Cluster of differentiation (CD) 35 was examined immunohistochemically in 15 cases of thyroid MALT lymphoma using paraffin-embedded, formalin-fixed tissue specimens. In all cases of thyroid MALT lymphoma, human Tg was detected immunohistochemically in the follicular epithelial cells and follicular dendritic cells (FDCs). These FDCs were positive by double immunostaining for anti-human Tg rabbit polyclonal antibody (Ab) and for CD35. Results showed that the Tg, a thyroid autoantigen, had immunostained the germinal center of the thyroid MALT lymphoma. The Tg was present in the FDCs, as revealed by the staining pattern of the germinal center;this fact was confirmed by double immunostaining of anti-human Tg mouse monoclonal Ab and anti-CD35 mouse monoclonal Ab. The results of our study suggest that Tg is an autoantigen that is recognized by thyroid MALT lymphoma cells.

キーワード
thyroglobulin
follicular dendritic cells
mucosa-associated lymphoid tissue lymphoma
Amo Type
Original Article
発行日
2009-04
出版物タイトル
Acta Medica Okayama
63巻
2号
出版者
Okayama University Medical School
開始ページ
71
終了ページ
78
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT