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ID 31574
JaLCDOI
フルテキストURL
著者
Shinagawa, Katsuji Second Department of Internal Medicine, Okayama University Medical School
Imajo, Kenji Second Department of Internal Medicine, Okayama University Medical School
Tada, Shinya Second Department of Internal Medicine, Okayama University Medical School
Tsubota, Teruhiko Second Department of Internal Medicine, Okayama University Medical School
Kimura, Ikuro Second Department of Internal Medicine, Okayama University Medical School
抄録
The activity of pulmonary lymphocytes was evaluated by the detection of interleukin-2 (IL-2) receptor alpha mRNA expression in lung cancer patients associated with diffuse interstitial shadow on roentgenograms of their lungs. Reverse transcription coupled with the polymerase chain reaction was used to detect mRNA expression. In 5 of 6 patients, IL-2R alpha mRNA expression was increased in pulmonary lymphocytes compared with 4 normal controls. The expression in this mRNA in peripheral blood lymphocytes was almost undetectable in either normal controls or these patients. These results suggest that pulmonary lymphocytes in patients with lung cancer associated with diffuse interstitial shadows are activated and may promote the inflammatory process generating pulmonary fibrosis.
キーワード
pulmonary fibrosis
lung cancer
pulmonary lymphocytes
IL-2R α mRNA
RT-PCR
Amo Type
Article
発行日
1993-04
出版物タイトル
Acta Medica Okayama
47巻
2号
出版者
Okayama University Medical School
開始ページ
73
終了ページ
78
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
Copyright© 1999 Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/5957