| 著者 | 中川 和彦| 野口 雄司| 奥村 英雄| 佐藤 修一郎| 田中 志幸| 下野 玄英| アリ・エルディブ アリ モハメド| 青江 基| 小野 俊朗| 上中 明子| 大原 信哉| 吉野 正| 山下 和城| 角田 司| 清水 信義| 中山 睿一| |
|---|---|
| 発行日 | 2007-09-03 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 119巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 後藤田 達洋| 川野 誠司| 河野 吉泰| 三浦 公| 神崎 洋光| 岩室 雅也| 河原 祥朗| 田中 健大| 吉野 正| 白川 靖博| 田端 雅弘| 谷本 光音| 岡田 裕之| |
|---|---|
| 発行日 | 2016-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 128巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 吉野 正| 赤木 忠厚| |
|---|---|
| 発行日 | 2001-04-28 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 113巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| タイトル（別表記） | Magnified observation of spontaneous morphological changes of duodenal follicular lymphoma |
|---|---|
| フルテキストURL | 128_111.pdf |
| 著者 | 岩室 雅也| 高田 尚良| 川野 誠司| 河原 祥朗| 吉野 正| 岡田 裕之| |
| 抄録 | A 63-year-old Japanese woman was diagnosed with duodenal follicular lymphoma. The initial esophagogastroduodenoscopic examination with magnifying observation revealed opaque white spots and enlarged whitish villi. Nine months later, esophagogastroduodenoscopy showed that the size of the lymphoma lesion decreased, and only opaque white spots were visible. The histological analysis of biopsy samples obtained during the initial endoscopy examination showed both neoplastic follicles and an inter-follicular infiltration of lymphoma cells, whereas the biopsy samples obtained at the endoscopy performed 9 months later showed only neoplastic follicle formation. These results suggest that the magnifying endoscopic features may reflect the underlying pathological mechanisms : enlarged whitish villi are probably due to lymphoma cell infiltration in the inter-follicular area, and opaque white spots are probably caused by neoplastic follicle formation. |
| キーワード | 消化管原発濾胞性リンパ腫（primary gastrointestinal follicular lymphoma） 悪性リンパ腫（malignant lymphoma） 拡大内視鏡検査（magnifying endoscopy） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2016-08-01 |
| 巻 | 128巻 |
| 号 | 2号 |
| 開始ページ | 111 |
| 終了ページ | 116 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.128.111 |
| 言語 | Japanese |
| 著作権者 | Copyright (c) 2016 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.128.111 |
| NAID | 130005262531 |
| 著者 | 大熊 佑| 劉 克約| 和気 秀徳| 春間 純| 吉野 正| 大塚 愛二| 高橋 英夫| 森 秀治| 西堀 正洋| 伊達 勲| |
|---|---|
| 発行日 | 2013-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 125巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 高田 尚良| 佐藤 康晴| 中村 直哉| 徳中 摩美| 三木 由香里| 菊池 イアーラ幸江| 五十嵐 和彦| 伊藤 悦郎| 張替 秀雄| 加藤 省一| 林 詠子| 岡 剛史| 星井 嘉信| 田利 晶| 岡田 裕之| Mohamado, ABD Alkader Lamia| 前田 嘉信| 谷本 光音| 木下 朝博| 吉野 正| |
|---|---|
| 発行日 | 2013-08-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 125巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 劉 克約| 森 秀治| 高橋 英夫| 友野 靖子| 和気 秀徳| 菅家 徹| 佐藤 康晴| 平賀 憲人| 足立 尚登| 吉野 正| 西堀 正洋| |
|---|---|
| 発行日 | 2008-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 120巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 高田 尚良| 吉野 正| |
|---|---|
| 発行日 | 2008-01-04 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 119巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/30493 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Teramoto, Norihito| Cao, liu| Kawasaki, Nobuhiro| Tonoyama, Yuji| Sarker, Ashit Baran| Yoshino, Tadashi| Takahashi, Kiyoshi| Akagi, Tadaatsu| |
| 抄録 | <p><P>Reed-Sternberg cells (RS cells) of Hodgkin's disease (HD) are frequently infected with Epstein-Barr virus (EBV) and express EBV-encoded nonpolyadenylated RNA transcripts (EBER)-1. EBV latency has been classified into three distinct forms: Latency I, expressing only one of the latent proteins, EBV nuclear antigen (EBNA)-1, latency II, coexpressing EBNA-1 and LMPs, and latency III, expressing all latent viral proteins. RS cells express LMP-1 in addition to EBNA-1 and are considered to be EBV latency II frequently encountered in nasopharyngeal carcinoma. We examined 13 cases of EBV-infected HD by combined EBER-1 in situ hybridization and immunostaining for LMP-1. All of the RS cells expressed EBER-1, but a substantial number of EBER-1+ RS, cells were negative for LMP-1. The percentage of LMP-1+ RS cells out of EBER-1+ RS cells varied from 7% to 100% (average 69%). In this study, we showed that all EBV-infected RS cells were not restricted to latency II, and some belonged to latency I.</P></p> |
| キーワード | in situ hybridization EBER-1 immunohistochemistry latecy |
| Amo Type | Article |
| 発行日 | 1996-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 50巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 267 |
| 終了ページ | 270 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 8914680 |
| Web of Sience KeyUT | A1996VQ20600006 |
| JaLCDOI | 10.18926/AMO/30509 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Yanai, Hiroyuki| Yoshino, Tadashi| Takahashi, Kiyoshi| Ninomiya, Yoshifumi| Akagi, Tadaatsu| |
| 抄録 | <p>Circulating hepatitis C virus (HCV) particles can be fractionated by means of differential flotation centrifugation. It is reported that in the bottom fraction HCV is in the form immune complexes, whereas in the top, it is free of antibodies. We evaluated the significance of circulating complex and free HCV in chronic hepatitis C, and assessed the relationship in terms of the response to interferon (IFN) therapy. We examined sera before, just after, and 1 year after administering IFN to 18 patients with chronic hepatitis C, 10 of whom responded (group CR), and 8 did not (group NR). The amounts of virus were similar between both groups before therapy. After differential flotation centrifugation with 1.063 g/ml of NaCl, the top and bottom fractions were assayed for HCV RNA. Before therapy, HCV RNA was detected in the top fraction in 1 of 10 in group CR, and in 6 of 8 in group NR (P < 0.05, chi-square test). HCV RNA was positive in the bottom fraction of all samples. In a follow-up study of group NR, HCV RNA was detected in the top fraction in 3 of 8 just after IFN therapy, and in 7 of 8 after 1 year. This study suggests that the presence of HCV in the top fraction can predict a poor response to IFN therapy.</p> |
| キーワード | IL-2R ??chain phorbol ester monocyte differentiation protein kinase |
| Amo Type | Article |
| 発行日 | 1996-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 50巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 145 |
| 終了ページ | 150 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 8805853 |
| Web of Sience KeyUT | A1996UU60400005 |
| JaLCDOI | 10.18926/AMO/30452 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Moreira, Luis Fernando| Iwagaki, Hiromi| Watanabe, Kazuhiko| Yoshino, Tadashi| Fuchimoto, Sadanori| Orita, Kunzo| |
| 抄録 | <p>A rare gastrointestinal tract neoplasm, primary non-Hodgkin's B-cell lymphoma in a 39-year-old, asymptomatic woman is described. The tumor was originally localized in the rectum without evidence of any other lymphoma-involved organ and treated by curative surgical procedure associated with postoperative chemotherapy.</p> |
| キーワード | primary lymphoma rectum surgical treatment |
| Amo Type | Article |
| 発行日 | 1990-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 44巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 279 |
| 終了ページ | 282 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 2260500 |
| Web of Sience KeyUT | A1990EG00700008 |
| JaLCDOI | 10.18926/AMO/31108 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Miyatani, Katsuya| Takahashi, Kiyoshi| Yanai, Hiroyuki| Yoshino, Tadashi| Akagi, Tadaatsu| |
| 抄録 | <p>Previously, we reported that interleukin-2 (IL-2)-stimulated helper T cells produced an unknown soluble factor which induced dendritic cell-like differentiation in primary cultures of monocytic leukemia cells and we referred to this factor as dendritic cell differentiation factor (DCDF). In this study, we attempted to purify and characterize DCDF and investigated its biological effect on normal human monocytes. Gel filtration chromatography indicated that the molecular weight of DCDF is approximately 30-35 kDa. Chromatofocusing indicated that the isoelectric point of DCDF is approximately 5.0. DCDF, partially purified by subsequent gel filtration, chromatofocusing, and hydrophobic chromatography, significantly enhanced the HLA-DR expression of normal human monocytes and a human monocytic leukemia cell line, THP-1. This biological activity was not neutralized by any known antibodies to human cytokines. DCDF significantly amplified the T-cell stimulatory activity of monocytes in the allogeneic mixed leukocyte reaction (MLR). Moreover, DCDF significantly enhanced IL-1 beta and IL-6 production by monocytes in a dose-dependent manner. These results suggest that DCDF is a novel human cytokine which stimulates the accessory cell function of monocytes.</p> |
| キーワード | dendritic cell differentiation protein purification cytokine |
| Amo Type | Article |
| 発行日 | 1994-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 48巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 67 |
| 終了ページ | 72 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 8042536 |
| Web of Sience KeyUT | A1994NJ77500001 |
| JaLCDOI | 10.18926/AMO/30854 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Akagi, Tadaatsu| Nose, Soichiro| Takahashi, Kiyoshi| Yoshino, Tadashi| Horie, Yasushi| Motoi, Makoto| Sonobe, Hiroshi| Enzan, Hideaki| |
| 抄録 | <p>In the human lymphoreticular system, the alpha and beta subunits of S-100 protein are found in ordinary monocyte-macrophages and non-phagocytic histiocytes such as Langerhans cells and interdigitating reticulum cells, respectively. The beta subunit is also present in some CD8+ T cells. In the present study, we investigated the ontogeny of these histiocytes and lymphocytes in humans. Yolk sacs and 4 to 21-week fetuses were examined immunohistochemically for the presence of S-100 protein subunits using antisera monospecific to each subunit. S-100 alpha + macrophages were present in the yolk sacs and the hepatic sinusoids of the 4th week embryos prior to bone marrow hematopoiesis. These macrophages later appeared in other lymphoid organs when anlagen of these organs were formed. No S-100 beta + cells were found in the yolk sacs. S-100 beta+ histiocytes were first detected in the hepatic sinusoids of the 5th week embryo, and after the 8th week of gestation, they were distributed in other lymphoid organs. S-100 beta+ lymphocytes were not found in the liver. They were first detected in the thymus at the 12th week of gestation, and were subsequently distributed in other lymphoid organs. These results suggest that S-100 beta+ lymphocytes and histiocytes may belong to different cell lineages, and the former may not be the precursor of the latter.</p> |
| キーワード | S-100 protein ontogeny lymphocyte histiocyte |
| Amo Type | Article |
| 発行日 | 1989-08 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 43巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 203 |
| 終了ページ | 210 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 2678903 |
| Web of Sience KeyUT | A1989AP79100002 |
| 著者 | Miki, Yukari| Gion, Yuka| Mukae, Yuriko| Hayashi, Atsushi| Sato, Hiaki| Yoshino, Tadashi| Takahashi, Kiyoshi| |
|---|---|
| 発行日 | 2013-02 |
| 出版物タイトル | European Journal of Haematology |
| 巻 | 90巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/31765 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Ohtsuki, Yuji| Danbara, Yoshifumi| Takeda, Isao| Takahashi, Kiyoshi| Hayashi, Kazuhiko| Sonobe, Hiroshi| Yoshino, Tadashi| Akagi, Tadaatsu| |
| 抄録 | <p>Metaplastic bony tissue along with hyperplastic mucosal epithelium showing no atypism was detected in biopsy materials from a Yamada type I gastric polyp. The tissue was metaplastic woven bone associated with calcification. Histogenesis of the bone formation is as yet unknown. This is the first reported case of the presence of metaplastic bone accompanied by hyperplastic gastric mucosa so far.</p> |
| キーワード | stomach hyperplastic polyp metaplastic bone histopathology |
| Amo Type | Article |
| 発行日 | 1987-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 41巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 43 |
| 終了ページ | 46 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 3105253 |
| Web of Sience KeyUT | A1987G146400007 |
| JaLCDOI | 10.18926/AMO/53120 |
|---|---|
| フルテキストURL | 69_1_37.pdf |
| 著者 | Iwamuro, Masaya| Okada, Hiroyuki| Takata, Katsuyoshi| Kawai, Yoshinari| Kawano, Seiji| Nasu, Junichiro| Kawahara, Yoshiro| Tanaka, Takehiro| Yoshino, Tadashi| Yamamoto, Kazuhide| |
| 抄録 | The sensitivity and specificity of magnified endoscopic features for differentiating follicular lymphoma from other diseases with duodenal whitish lesions have never been investigated. Here we compared the magnified endoscopic features of duodenal follicular lymphoma with those of other whitish lesions. We retrospectively reviewed the cases of patients with follicular lymphoma (n＝9), lymphangiectasia (n＝7), adenoma (n＝10), duodenitis (n＝4), erosion (n＝1), lymphangioma (n＝1), and hyperplastic polyp (n＝1). The magnified features of the nine follicular lymphomas included enlarged villi (n＝8), dilated microvessels (n＝5), and opaque white spots of various sizes (n＝9). The lymphangiectasias showed enlarged villi, dilated microvessels, and white spots, but the sizes of the white spots were relatively homogeneous and their margin was clear. Observation of the adenoma and duodenitis revealed only whitish villi. Although the lymphangioma was indistinguishable from the follicular lymphomas by magnified features, it was easily diagnosed based on the macroscopic morphology. In conclusion, magnified endoscopic features, in combination with macroscopic features, are useful for differentiating follicular lymphomas from other duodenal diseases presenting whitish lesions. |
| キーワード | duodenal neoplasm follicular lymphoma gastrointestinal lymphoma magnifying endoscopy |
| Amo Type | Original Article |
| 発行日 | 2015-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 69巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 37 |
| 終了ページ | 44 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25703169 |
| Web of Sience KeyUT | 000349740300004 |
| 著者 | Iwatani, Kayoko| Takata, Katsuyoshi| Sato, Yasuharu| Miyata-Takata, Tomoko| Iwaki, Noriko| Cui, Wei| Sawada-Kitamura, Seiko| Sonobe, Hiroshi| Tamura, Maiko| Saito, Katsuhiko| Miyatani, Katsuya| Yamasaki, Rie| Yamadori, Ichiro| Fujii, Nobuharu| Terasaki, Yasushi| Maeda, Yoshinobu| Tanimoto, Mitsune| Nakamura, Naoya| Yoshino, Tadashi| |
|---|---|
| 発行日 | 2014-07 |
| 出版物タイトル | Human Pathology |
| 巻 | 45巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/51072 |
|---|---|
| フルテキストURL | 67_4_265.pdf |
| 著者 | Hanakawa, Hiroyuki| Orita, Yorihisa| Sato, Yasuharu| Uno, Kinya| Nishizaki, Kazunori| Yoshino, Tadashi| |
| 抄録 | We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was observed, confirming our diagnosis. |
| キーワード | ulceration methotrexate oropharynx lymphoproliferative disorders |
| Amo Type | Case Report |
| 発行日 | 2013-08 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 67巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 265 |
| 終了ページ | 269 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23970326 |
| Web of Sience KeyUT | 000323470100009 |
| JaLCDOI | 10.18926/AMO/31848 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Iishi, Tatsuhiko| Hiraki, Takao| Mimura, Hidefumi| Gobara, Hideo| Kurose, Taichi| Fujiwara, Hiroyasu| Sakurai, Jun| Yanai, Hiroyuki| Yoshino, Tadashi| Kanazawa, Susumu| |
| 抄録 | <p>The present study was performed to clarify the effect of hypertonic saline infusion into the lung parenchyma on radiofrequency ablation (RFA) of the lungs. A total of 20 ablation zones were created in 3 pigs. The ablation zones were divided into 3 groups. Group 1 (n6) consisted of ablation zones created by applying smaller radiofrequency (RF) power without saline infusion;group 2 (n5) zones were created by applying greater RF power without saline infusion;and group 3 (n9) zones were created by applying greater RF power with saline infusion. The techniques of saline infusion included administration of hypertonic saline 1ml before RFA, followed by continuous administration at a rate of 1ml/min during the first 2min after the initiation of RFA. The ablation parameters and coagulation necrosis volumes were compared among the groups. Group 3 had a tendency toward smaller mean impedance than group 1 (p0.059) and group 2 (p0.053). Group 3 showed significantly longer RF application time than group 2 (p0.004) and significantly greater maximum RF power than group 1 (p0.001) and group 2 (p0.004). Group 3 showed significantly larger coagulation necrosis volume (mean, 1,421mm3) than group 2 (mean, 858mm3, p0.039) and had a tendency toward larger necrosis volume than group 1 (mean, 878mm3, p0.077). Although this small study had limited statistical power, hypertonic saline infusion during RFA appeared to enlarge coagulation necrosis of the lung parenchyma.</p> |
| キーワード | radiofrequency ablation lung experimental study |
| Amo Type | Original Article |
| 発行日 | 2009-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 63巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 137 |
| 終了ページ | 144 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 19571900 |
| Web of Sience KeyUT | 000267388200003 |