ID | 30484 |
JaLCDOI | |
フルテキストURL | |
著者 |
Tonoyama, Yuji
Okayama University
Teramoto, Norihiro
Okayama University
Sarker, Ashit Baran
Okayama Univeristy
Hayashi, Kazuhiko
Okayama University
Takahashi, Kiyoshi
Okayama University
Akagi, Tadaatsu
Okayama University
|
抄録 | To elucidate the latent state and reactivation of Epstein-Barr virus (EBV) in non-neoplastic lymphoid lesions, we investigated 144 non-neoplastic lymphoid lesions by in situ hybridization (ISH) to detect the expression of EBV-encoded small RNAs (EBER)-1 and BCRF-1 and by immunostaining for latent membrane protein (LMP)-1 and ZEBRA. ISH for EBER-1 detected EBER-1-positive cells (EPC) in 31 of the 144 examined lesions (22%). EPC were detected in 4 of 49 cases of nonspecific lymphoid hyperplasia, in 16 of 20 abscess-forming granulomatous lymphadenitis (AFGL), 5 of 25 Kikuchi's disease, and in 3 of 3 infectious mononucleosis. LMP-1 was expressed in 6 of 124 non-neoplastic lymphoid lesions (4.8%). LMP-1-positive cells were observed in 6 of the 31 EBER-1-positive cases (19%). EPC were detected significantly more frequently in LMP-1- and ZEBRA-positive specimens than in the LMP-1- and ZEBRA-negative specimens. BCRF-1 was expressed in 4 of 11 cases examined: 2 of 3 AFGL, 1 of 2 Kikuchi's disease, and in the 1 case of atypical lymphoid hyperplasia. This study suggests that Epstein-Barr virus is prevalent and can be reactivated in the lymph nodes effaced by destructive inflammation, such as AFGL. Such inflammation may provide a local milieu that is conducive for EBV to enter the lytic cycle. |
キーワード | EBER-I
BCRF-l
LMP-l
ZEBRA
lymphoid lesion
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1996-04
|
巻 | 50巻
|
号 | 2号
|
出版者 | Okayama University Medical School
|
開始ページ | 89
|
終了ページ | 96
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT | |
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/5331
|