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ID 51011
フルテキストURL
著者
Esumi, Satoru Department of Pharmacy, Okayama University Hospital
Sagara, Hidenori Department of Pharmaceutical Information Sciences, Matsuyama University
Nakamoto, Akihiko Department of Pharmacy, Okayama University Hospital
Kawasaki, Yoichi Department of Pharmacy, Okayama University Hospital
Gomita, Yutaka School of Pharmacy, Shujitsu University
Sendo, Toshiaki Department of Pharmacy, Okayama University Hospital
抄録
Rationale: It was recently demonstrated that the priming stimulation effect (PSE) in the runway model of intracranial self-stimulation (ICSS) can be used as a model system to study the motivational effects of drugs. However, the characteristics of this navel experimental model have not been fully clarified. Objective: To elucidate the involvement of dopamine uptake inhibition in motivated behavior and the difference in experimental characteristics between closely related experimental models, we investigated the effects of the dopamine uptake inhibitor GBR12909 in the runway ICSS model, in the forced swimming test (FST), and on conditioned place preference (CPP). In addition, the role of dopamine receptor signaling in the runway model was evaluated using dopamine receptor agonists and antagonists. Results: GBR12909 dose-dependently increased running speed on the runway and decreased immobility time in the FST without affecting the time spent in the drug-associated compartment in CPP tests. The effect of GBR12909 in the runway model was inhibited by pre-treatment with the dopamine receptor antagonists haloperidol and raclopride. The dopamine receptor agonists SKF38393 and quinpirole dose-dependently decreased running speed. Conclusions: These results demonstrate that GBR12909 displays motivation-enhancing and antidepressant-like effects without place conditioning effects. In addition, the mechanisms of PSE enhancement in the runway ICSS model are different from those underlying closely associated experimental models and are mediated by increases in dopamine signaling.
キーワード
Motivation
Intracranial Self-stimulation
Forced swimming test
Conditioned place preference
GBR12909
Quinpirole
発行日
2013-04-15
出版物タイトル
Behavioural Brain Research
243巻
開始ページ
313
終了ページ
321
ISSN
0166-4328
資料タイプ
学術雑誌論文
オフィシャル URL
http://www.sciencedirect.com/science/article/pii/S0166432812007012
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/50696
言語
English
著作権者
(C) 2012 Elsevier B.V. All rights reserved.
論文のバージョン
author
査読
有り
DOI
Web of Science KeyUT