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ID 34164
フルテキストURL
著者
Kitamura, Yoshihisa Okayama University ORCID Kaken ID researchmap
Akiyama, Kozue Okayama University Medical School
Kitagawa, Kouhei Okayama University Medical School
Shibata, Kazuhiko Okayama University Medical School
Kawasaki, Hiromu Okayama University
Suemaru, Katsuya Ehime University Medical School
Araki, Hiroaki Ehime University Medical School
Sendo, Toshiaki Okayama University Medical School Kaken ID researchmap
Gomita, Yutaka Okayama University Medical School
抄録

The use of carbamazepine has been reported to be an effective treatment for severe depression. We have already shown that the antidepressant-like effects of tricyclic antidepressants in the rat forced swim test (FST) are blocked by chronic treatment with adrenocorticotropic hormone (ACTH). In the present study, we examined the effect of the chronic administration of carbamazepine on the FST and the wet-dog shakes induced by (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aiminopropane (DOI), a 5-HT2A receptor agonist, in ACTH-treated rats. Chronic administration of carbamazepine did not affect the duration of immobility in saline-treated and ACTH-treated rats. The reduction of immobility, induced by chronic administration of imipramine, was blocked by treatment with ACTH. When carbamazepine was administered concurrently with imipramine, we observed a significant decrease in immobility in rats treated with ACTH. Chronic ACTH treatment increased the number of the wet-dog shakes induced by DOI. This effect of ACTH was significantly increased by the coadministration of carbamazepine and imipramine. These results suggest that the use of carbamazepine together with tricyclic antidepressants had the effect of reducing immobility time in the FST in a tricyclic antidepressant-treatment-resistant depressive model induced by chronic ACTH treatment.

キーワード
Imipramine
Carbamazepine
ACTH
5-HT2A receptor
Forced swim test
Wet-dog shakes
Treatment–resistant
備考
Published with permission from the copyright holder.
This is a author's copy,as published in Pharmacology Biochemistry and Behavior , 2008, volume 89, issue 3, pp235-240.
発行日
2008-05-20
出版物タイトル
Pharmacology Biochemistry and Behavior
89巻
3号
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
author
DOI
Web of Science KeyUT