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ID 30940
JaLCDOI
フルテキストURL
著者
Sagara, Hidenori Department of Pharmacy, Okayama University Hospital
Kitamura, Yoshihisa Department of Pharmaceutical Care and Health Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Esumi, Satoru Department of Pharmacy, Okayama University Hospital
Sendo, Toshiaki Department of Pharmacy, Okayama University Hospital Kaken ID researchmap
Araki, Hiroaki Division of Pharmacy, Ehime University Hospital
Gomita, Yutaka Department of Pharmacy, Okayama University Hospital
抄録

It is well known that priming stimulation promotes the motivational effects of intracranial self-stimulation(ICSS) behavior. An experimental methodology using the runway method could separately study the reward and motivational effects of ICSS behavior. In the present study, we examined the motivational effect of nicotine as measured by the runway method using priming stimulation of ICSS behavior. Electrodes were implanted chronically into the medial forebrain bundle (MFB) in rats. A lever for stimulation of the MFB was set on the opposite side of the start box in the apparatus, and rats were trained to get a reward stimulation (50-200 microA, 0.2 ms, 60 Hz) of MFB when the goal lever was pressed. After the rats were trained to press the lever, a priming stimulation of the MFB was performed. After receiving the priming stimulation, rats were placed at the start box of the runway apparatus, and the running time duration until the goal lever was pressed was measured. Subcutaneous injection of nicotine at a dose of 0.2mg/kg produced an increase in running speed to obtain the reward stimulation, and priming stimulation facilitated the motivational effect to obtain the electrical brain stimulation reward in the rats. These results suggest that nicotine significantly enhanced the motivational effect on ICSS behavior as determined using the runway method. The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs.

キーワード
intracranial self-stimulation
runway
nicotine
priming stimulation
motivational effect
Amo Type
Original Article
発行日
2008-08
出版物タイトル
Acta Medica Okayama
62巻
4号
出版者
Okayama University Medical School
開始ページ
227
終了ページ
233
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT