ID | 52337 |
フルテキストURL | |
著者 |
Kitagawa, Masashi
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
Sugiyama, Hitoshi
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
ORCID
Kaken ID
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Morinaga, Hiroshi
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Inoue, Tatsuyuki
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Takiue, Keiichi
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Ogawa, Ayu
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Yamanari, Toshio
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Kikumoto, Yoko
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Uchida, Haruhito Adam
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
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Kitamura, Shinji
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
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Maeshima, Yohei
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
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Nakamura, Kazufumi
Okayama Univ, Dept Cardiovasc Med, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
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Ito, Hiroshi
Okayama Univ, Dept Cardiovasc Med, Grad Sch Med Dent & Pharmaceut Sci
Kaken ID
Makino, Hirofumi
Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
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抄録 | Background: Klotho was originally identified in a mutant mouse strain unable to express the gene that consequently showed shortened life spans. In humans, low serum Klotho levels are related to the prevalence of cardiovascular diseases in community-dwelling adults. However, it is unclear whether the serum Klotho levels are associated with signs of vascular dysfunction such as arterial stiffness, a major determinant of prognosis, in human subjects with chronic kidney disease (CKD).
Methods: We determined the levels of serum soluble Klotho in 114 patients with CKD using ELISA and investigated the relationship between the level of Klotho and markers of CKD-mineral and bone disorder (CKD-MBD) and various types of vascular dysfunction, including flow-mediated dilatation, a marker of endothelial dysfunction, ankle-brachial pulse wave velocity (baPWV), a marker of arterial stiffness, intima-media thickness (IMT), a marker of atherosclerosis, and the aortic calcification index (ACI), a marker of vascular calcification.
Results: The serum Klotho level significantly correlated with the 1,25-dihydroxyvitamin D level and inversely correlated with the parathyroid hormone level and the fractional excretion of phosphate. There were significant decreases in serum Klotho in patients with arterial stiffness defined as baPWV >= 1400 cm/sec, atherosclerosis defined as maximum IMT >= 1.1 mm and vascular calcification scores of ACI>0%. The serum Klotho level was a significant determinant of arterial stiffness, but not endothelial dysfunction, atherosclerosis or vascular calcification, in the multivariate analysis in either metabolic model, the CKD model or the CKD-MBD model. The adjusted odds ratio of serum Klotho for the baPWV was 0.60 (p = 0.0075).
Conclusions: Decreases in the serum soluble Klotho levels are independently associated with signs of vascular dysfunction such as arterial stiffness in patients with CKD. Further research exploring whether therapeutic approaches to maintain or elevate the Klotho level could improve arterial stiffness in CKD patients is warranted.
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発行日 | 2013-02-19
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出版物タイトル |
PLoS ONE
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巻 | 8巻
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号 | 2号
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出版者 | Public Library Science
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ISSN | 1932-6203
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資料タイプ |
学術雑誌論文
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52241
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言語 |
英語
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著作権者 | © 2013 Kitagawa et al.
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
Web of Science KeyUT |