ID | 52783 |
フルテキストURL | |
著者 |
Kurahashi, Hiroaki
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol
Kaken ID
Watanabe, Masami
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol
Kaken ID
publons
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Sugimoto, Morito
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol
Kaken ID
Ariyoshi, Yuichi
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol
Mahmood, Sabina
Okayama Univ, Okayama Univ Hosp, Ctr Innovat Clin Med
Araki, Motoo
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol
ORCID
Kaken ID
publons
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Ishii, Kazushi
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol
Nasu, Yasutomo
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol
Kaken ID
publons
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Nagai, Atsushi
Kawasaki Med Univ, Dept Urol
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抄録 | Gender identity disorder (GID) results from a disagreement between a person's biological sex and the gender to which he or she identifies. With respect to the treatment of female to male GID, testosterone replacement therapy (TRT) is available. The uric acid (UA) level can be influenced by testosterone; however, the early effects and dose-dependency of TRT on the serum UA concentration have not been evaluated in this population. We herein conducted a dose-response analysis of TRT in 160 patients with female to male GID. The TRT consisted of three treatment groups who received intramuscular injections of testosterone enanthate: 125 mg every two weeks, 250 mg every three weeks and 250 mg every two weeks. Consequently, serum UA elevation was observed after three months of TRT and there was a tendency toward testosterone dose-dependency. The onset of hyperuricemia was more prevalent in the group who received the higher dose. We also demonstrated a positive correlation between increased levels of serum UA and serum creatinine. Since the level of serum creatinine represents an individual's muscle volume and the muscle is a major source of purine, which induces UA upregulation, the serum UA elevation observed during TRT is at least partially attributed to an increase in muscle mass. This is the first study showing an association between serum UA elevation and a TRT-induced increase in muscle mass. The current study provides important information regarding TRT for the follow-up and management of the serum UA levels in GID patients.
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キーワード | Gender identity disorder
Testosterone
Uric acid
Creatinine
Muscle
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発行日 | 2013-12
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出版物タイトル |
Endocrine Journal
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巻 | 60巻
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号 | 12号
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開始ページ | 1321
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終了ページ | 1327
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ISSN | 0918-8959
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | ©The Japan Endocrine Society
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
Web of Science KeyUT |