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ID 32167
JaLCDOI
フルテキストURL
著者
Okazaki, Morihiro Okayama University
Kitani, Hikaru Okayama University
Mifune, Takashi Okayama University
Mitsunobu, Fumihiro Okayama University Kaken ID publons researchmap
Asaumi, Noboru Okayama University
Tanizaki, Yoshiro Okayama University
Harada, Hideo Okayama University
Takahashi, Kiyoshi Okayama University
Kimura, Ikuro Okayama University
抄録

Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in specific IgG4 was dependent on the total dose of house dust administered in both children (r = 0.636, p less than 0.001) and adults (r = 0.629, p less than 0.01). However, the increase of specific IgG4 in adults was not as apparent as in children. These results might suggest that mite specific IgG4 is a useful immunological marker in the immunotherapy for allergic asthma, and that IgG4 antibody acts as a blocking antibody in atopic bronchial asthma.

キーワード
house dust mite
bronchial asthma
hyposensitization
specific IgG4
Amo Type
Article
出版物タイトル
Acta Medica Okayama
発行日
1991-08
45巻
4号
出版者
Okayama University Medical School
開始ページ
267
終了ページ
273
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
英語
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT