ID | 32167 |
JaLCDOI | |
フルテキストURL | |
著者 |
Okazaki, Morihiro
Okayama University
Kitani, Hikaru
Okayama University
Mifune, Takashi
Okayama University
Asaumi, Noboru
Okayama University
Tanizaki, Yoshiro
Okayama University
Harada, Hideo
Okayama University
Takahashi, Kiyoshi
Okayama University
Kimura, Ikuro
Okayama University
|
抄録 | Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in specific IgG4 was dependent on the total dose of house dust administered in both children (r = 0.636, p less than 0.001) and adults (r = 0.629, p less than 0.01). However, the increase of specific IgG4 in adults was not as apparent as in children. These results might suggest that mite specific IgG4 is a useful immunological marker in the immunotherapy for allergic asthma, and that IgG4 antibody acts as a blocking antibody in atopic bronchial asthma. |
キーワード | house dust mite
bronchial asthma
hyposensitization
specific IgG4
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1991-08
|
巻 | 45巻
|
号 | 4号
|
出版者 | Okayama University Medical School
|
開始ページ | 267
|
終了ページ | 273
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |