フルテキストURL Acta_Otolaryngol_137_5_529.pdf Acta_Otolaryngol_137_5_529_image.pdf
著者 Kariya, Shin| Okano, Mitsuhiro| Oto, Takahiro| Higaki, Takaya| Haruna, Takenori| Noda, Yohei| Nishizaki, Kazunori|
抄録 CONCLUSIONS: Chronic rhinosinusitis diagnosed according to the European Position Paper on Rhinosinusitis and Nasal Polyps 2012, not by computed tomography alone, is one of the prognostic factors affecting long-term survival in patients with lung transplantation. Endoscopic sinus surgery might play a beneficial role in the management of lung transplantation recipients with chronic rhinosinusitis. OBJECTIVE: To show the effect of paranasal sinus infection on post-lung transplantation survival. METHOD: Lung transplantation recipients were included in this study. Computed tomography was performed before and after lung transplantation. The severity of chronic rhinosinusitis was evaluated by Lund-Mackay scoring system. The survival rate was calculated by the Kaplan-Meier method. RESULTS: One hundred and forty-eight patients received lung transplantation for various indications. Chronic rhinosinusitis was found in 18.9% (28/148) of the lung transplantation recipients. Of 28 patients with chronic rhinosinusitis, seven patients underwent endoscopic sinus surgery due to persistent post-nasal drip. The recipients with chronic rhinosinusitis who did not receive endoscopic sinus surgery (n = 21) showed a significantly lower survival rate as compared to the patients without chronic rhinosinusitis. There was no statistically significant difference in the survival rate between the recipients with (n = 50) and without (n = 98) paranasal sinus abnormality on computed tomography.
キーワード Lung transplant bronchiolitis obliterans infection; pneumonia survival rate
備考 2018年5月公開予定
発行日 2017-05
出版物タイトル Acta Oto-laryngologica
137巻
5号
出版者 Taylor & Francis
開始ページ 529
終了ページ 533
ISSN 0001-6489
NCID AA0050923X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 27809696
DOI 10.1080/00016489.2016.1247497
Web of Sience KeyUT 000400167100014
関連URL https://doi.org/10.1080/00016489.2016.1247497
フルテキストURL K0005427_other1.pdf
著者 Okano, Mitsuhiro| Fujiwara, Tazuko| Kariya, Shin| Higaki, Takaya| Makihara, Sei-ichiro| Haruna, Takenori| Noyama, Yasuyuki| Koyama, Takahisa| Omichi, Ryotaro| Orita, Yorihisa| Miki, Kentaro| Kanai, Kengo| Nishizaki, Kazunori|
抄録 BACKGROUND: Toll-like receptor 3 (TLR3) is expressed in upper airways, however, little is known regarding whether Toll-like receptor 3 (TLR3) signals exert a regulatory effect on the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP), especially on eosinophilic inflammation. We sought to investigate the effect of Poly(IC), the ligand for TLR3, on cytokine production by dispersed nasal polyp cells (DNPCs). METHODS: DNPCs were pretreated with or without Poly(IC), and were then cultured in the presence or absence of staphylococcal enterotoxin B (SEB), following which the levels of IL-5, IL-10, IL-13, IL-17A and interferon (IFN)-γ in the supernatant were measured. To determine the involvement of IL-10 and cyclooxygenase in Poly(IC)-mediated signaling, DNPCs were treated with anti-IL-10 monoclonal antibody and diclofenac, the cyclooxygenase inhibitor, respectively. Poly(IC)-induced prostaglandin E2 (PGE2) production was also determined. RESULTS: Exposure to Poly(IC) induced a significant production of IL-10, but not of IL-5, IL-13, IL-17A or IFN-γ by DNPCs. Pretreatment with Poly(IC) dose-dependently inhibited SEB-induced IL-5, IL-13 and IL-17A, but not IFN-γ production. Neutralization of IL-10 significantly abrogated the inhibitory effect of Poly(IC). Treatment with diclofenac also abrogated the inhibitory effect of Poly(IC) on SEB-induced IL-5 and IL-13 production. However, unlike exposure of diclofenac-treated DNPCs to lipopolysaccharide, the ligand for TLR4, exposure of these cells to Poly(IC) did not enhance IL-5 or IL-13 production. Poly(IC) did not significantly increase PGE2 production by DNPCs. CONCLUSIONS: These results suggest that TLR3 signaling regulates eosinophilia-associated cytokine production in CRSwNP, at least in part, via IL-10 production.
キーワード Chronic rhinosinusitis with nasal polyps IL-10 IL-5 Poly(IC) Toll-like receptor
備考 学位審査副論文
発行日 2016-01
出版物タイトル Allergology international : official journal of the Japanese Society of Allergology
65巻
1号
出版者 Elsevier
開始ページ 96
終了ページ 102
ISSN 1323-8930
NCID AA11091750
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 26666485
Web of Sience KeyUT 000367238600015
関連URL https://doi.org/10.1016/j.alit.2015.08.005 http://ousar.lib.okayama-u.ac.jp/54846
著者 Higaki, T| Okano, M| Fujiwara, T| Makihara, S| Kariya, S| Noda, Y| Haruna, T| Nishizaki, K|
発行日 2012-08
出版物タイトル Clinical and Experimental Allergy
42巻
8号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/41323
フルテキストURL 64_6_375.pdf
著者 Kariya, Shin| Cureoglu, Sebahattin| Fukushima, Hisaki| Morita, Norimasa| Baylan, Muzeyyen Y.| Maeda, Yukihide| Nishizaki, Kazunori| Paparella, Michael M.|
抄録 This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel×100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls.
キーワード diabetes mellitus temporal bone cochlear spiral modiolar artery hearing loss
Amo Type Original Article
発行日 2010-12
出版物タイトル Acta Medica Okayama
64巻
6号
出版者 Okayama University Medical School
開始ページ 375
終了ページ 383
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21173807
Web of Sience KeyUT 000285664200004
著者 Kariya, Shin| Nishizaki, kazunori| Akagi, Hirofumi| Paparella, Michael M.|
発行日 2004-11
出版物タイトル Journal of Laryngology & Otology
118巻
11号
資料タイプ 学術雑誌論文
著者 假谷 伸|
発行日 2005-06-30
出版物タイトル
資料タイプ 学位論文