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ID 51467
フルテキストURL
著者
Toda, Hiroko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Sato, Yasuharu Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Takata, Katsuyoshi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Orita, Yorihisa Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg
Asano, Naoko Nagoya Univ Hosp, Dept Clin Lab
Yoshino, Tadashi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
抄録
Diffuse large B-cell lymphoma (DLBCL) comprises 2 molecularly distinct subgroups of non-germinal center B-cell-like (non-GCB) and germinal center B-cell-like (GCB) DLBCLs, with the former showing relatively poor prognosis. In the present study, we analyzed the clinicopathological features of 39 patients with localized nasal/paranasal DLBCL. Immunohistochemistry-based subclassification revealed that 11 patients (28%) were of the GCB-type according to Hans' algorithm and 11 (28%) were of the GCB-type according to Choi's algorithm. According to both Hans' and Choi's algorithms, the non-GCB type was predominant. Nevertheless, prognosis was good. Overall survival did not differ significantly between the GCB and non-GCB subgroups (Hans' algorithm: p = 0.57, Choi's algorithm: p = 0.99). Furthermore, the prognosis of localized nasal/paranasal DLBCL was better than that of other localized extranodal DLBCLs. The prognosis of extranodal DLBCL is usually considered poorer than that of nodal DLBCL. However, in our study, no difference was noted between patients with localized nasal/paranasal DLBCL and patients with localized nodal DLBCL. In conclusion, although the non-GCB subtype is thought to show poor prognosis, in our study, the prognosis for localized nasal/paranasal DLBCL patients was good irrespective of subclassification.
発行日
2013-02-28
出版物タイトル
PLoS ONE
8巻
2号
出版者
Public Library Science
ISSN
1932-6203
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1371/journal.pone.0057677
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51454
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT