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ID 16142
Eprint ID
16142
フルテキストURL
Thumnail 97_235.pdf 744 KB
タイトル(別表記)
Effect of cepharanthine on lipid peroxidation
著者
上者 郁夫 岡山大学医学部放射線医学教室
抄録
The effect of cepharanthine on radiation- and Fe(2+)-induced lipid peroxidation was examined. Cepharanthine and α-tocopherol inhibited radiation-induced lipid peroxidation of liposomes and Fe(2+)-induced lipid peroxidation of mitochondria. Cepharanthine reduced the velocity of Fe(2+)oxidation in the presence of mitochondria but not in the absence. α-Tocopherol strongly inhibited radiation-induced peroxidation of lipid dissolved in MeOH/CHCl(3)/H(2)O (v/v, 2/1/0.8) and Fe(2+)-induced peroxidation of lipid dissolved in MeOH. Cepharanthine, on the other hand, only weakly inhibited lipid peroxidation in the MeOH/CHCl(3)/H(2)O system, and did not inhibit peroxidation in the MeOH system. The change in the absorption stectrum of α-tocopherol and cepharanthine by free radicals (X irradiation) was measured. The reagents were dissolved in 95% EtOH acidified with 20mM HCl and MeOH/CHCl(3)/H(2)O (v/v, 2/1/0.8). α-Tocopherol exhibited a change in its absorption spectrum in both systems and seemed to be oxidized at a higher rate by radicals. However, cepharanthine did not exhibit a change in its absorption spectrum in acidified 95% EtOH exposed to X irradiation, and slightly exhibited a chang in its absorption spectrum in MeOH/CHCl(3)/H(2)O exposed to X irradiation. From these observations, cepharanthine seemed not to exhibit a radical-trapping ability.
キーワード
脂質過酸化反応 (Lipid peroxidation)
X線照射 (X-irradiation)
二価鉄 (Ferrous ion)
セファランチン (Cepharanthine)
α-トコフェロール (α-Tocopherol)
発行日
1985-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
97巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
235
終了ページ
248
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/97/3-4/97_3-4_235/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma