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ID 61490
フルテキストURL
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著者
Yoshino, Tadashi Department of Pathology, Okayama University Graduate School Kaken ID publons researchmap
Tanaka, Takehiro Department of Pathology, Okayama University Graduate School Kaken ID publons
Sato, Yasuharu Department of Pathology, Okayama University Graduate School ORCID Kaken ID researchmap
抄録
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) accounts for approximately 1% of all lymphomas in our department. In this article, we describe the differential diagnosis of CLL/SLL from other indolent lymphomas, with special reference to follicular lymphoma, marginal zone B-cell lymphoma, lymphoplasmacytic lymphoma, and mantle cell lymphoma, although the latter is considered to be aggressive. CLL/SLL often exhibits proliferation centers, similar to follicular lymphoma. Immunohistological examination can easily distinguish these two lymphomas. The most important characteristic of CLL/SLL is CD5 and CD23 positivity. Mantle cell lymphoma is also CD5-positive and there are some CD23-positive cases. Such cases should be carefully distinguished from CLL/SLL. Some marginal zone lymphomas are also positive for CD5 and such cases are often disseminated. Lymphoplasmacytic lymphoma should also be a differential diagnosis for CLL/SLL. It frequently demonstrates MYD88 L265P, which is a key differential finding. By immunohistological examination, the expression of lymphoid enhancer-binding factor 1 is specific for CLL/SLL and can be a good marker in the differential diagnosis.
キーワード
chronic lymphocytic leukemia/small lymphocytic lymphoma
differential diagnosis
indolent lymphoma
発行日
2020
出版物タイトル
Journal of Clinical and Experimental Hematopathology
60巻
4号
出版者
Japanese Society for Lymphoreticular Tissue Research
開始ページ
124
終了ページ
129
ISSN
1346-4280
NCID
AA11556796
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2020 by The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.3960/jslrt.19041
ライセンス
https://creativecommons.org/licenses/by-nc-sa/4.0/