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ID 57583
フルテキストURL
著者
Makihara, Seiichiro Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
Kariya, Shin Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Noujima-Harada, Mai Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
Ohara, Nobuya Department of Pathology, Kagawa Rosai Hospital
Naito, Tomoyuki Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
Matsumoto, Junya Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
Noda, Yohei Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Okano, Mitsuhiro Department of Otolaryngology, International University of Health and Welfare School of Medicine
Yoshino, Tadashi Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kaken ID publons researchmap
Nishizaki, Kazunori Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
抄録
As has been well recognized, methotrexate (MTX) leads to a state of immunosuppression and can provide a basis for the development of lymphoproliferative disorders (LPDs). MTX-associated LPDs can affect nodal sites as well as extranodal sites, though the manifestation of an LPD in the form of multiple pulmonary nodules is rare. Here, we report two cases of MTX-associated LPD with multiple bilateral pulmonary nodules, which was a finding suggestive of lung cancer, and bilateral cervical lymphadenopathy. After withdrawal of MTX, the multiple bilateral pulmonary nodules and bilateral cervical lymphadenopathy disappeared without chemotherapy in both cases. From these results, patients with pulmonary nodules and cervical lymphadenopathy should be examined for head and neck malignant tumors. Also, physicians should carefully check the administration of MTX. In patients with an MTX-associated LPD, we need to make an early diagnosis and consider discontinuing the administration of MTX as soon as possible.
キーワード
MTX-associated LPD
Methotrexate
Pulmonary nodules
備考
This fulltext will be available in Aug 2020
発行日
2019-12-31
出版物タイトル
Auris Nasus Larynx
46巻
6号
出版者
Elsevier
開始ページ
927
終了ページ
933
ISSN
03858146
NCID
AA00061157
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2019 Elsevier B.V. All rights reserved.
論文のバージョン
author
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1016/j.anl.2019.01.010
ライセンス
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
Citation
Seiichiro Makihara, Shin Kariya, Mai Noujima-Harada, Nobuya Ohara, Tomoyuki Naito, Junya Matsumoto, Yohei Noda, Mitsuhiro Okano, Tadashi Yoshino, Kazunori Nishizaki, Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy, Auris Nasus Larynx, Volume 46, Issue 6, 2019, Pages 927-933, ISSN 0385-8146, https://doi.org/10.1016/j.anl.2019.01.010.
助成機関名
文部科学省
助成番号
JP16K20249
オープンアクセス(出版社)
非OA
オープンアーカイブ(出版社)
非OpenArchive