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ID 58621
フルテキストURL
著者
Nakagawa, Saki Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Omori, Kazuhiro Department of Periodontics and Endodontics, Okayama University Hospital ORCID Kaken ID publons researchmap
Nakayama, Masaaki Department of Oral Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Mandai, Hiroki Department of Medical Technology, School of Health Science, Gifu University of Medical Science ORCID Kaken ID publons researchmap
Yamamoto, Satoshi Department of Periodontics and Endodontics, Okayama University Hospital
Kobayashi, Hiroya Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Universit
Sako, Hidefumi Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Sakaida, Kyosuke Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Yoshimura, Hiroshi ivision of Applied Chemistry, Graduate School of Natural Sciences and Technology, Okayama University
Ishii, Satoki Division of Applied Chemistry, Graduate School of Natural Sciences and Technology, Okayama University
Ibaragi, Soichiro Department of Oral Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
Hirai, Kimito Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Yamashiro, Keisuke Department of Periodontics and Endodontics, Okayama University Hospital ORCID Kaken ID publons
Yamamoto, Tadashi Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
Suga, Seiji Division of Applied Chemistry, Graduate School of Natural Sciences and Technology, Okayama University ORCID Kaken ID researchmap
Takashiba, Shogo Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
抄録
Pathophysiological bone resorption is commonly associated with periodontal disease and involves the excessive resorption of bone matrix by activated osteoclasts. Receptor activator of nuclear factor (NF)-κB ligand (RANKL) signaling pathways have been proposed as targets for inhibiting osteoclast differentiation and bone resorption. The fungal secondary metabolite (+)-terrein is a natural compound derived from Aspergillus terreus that has previously shown anti-interleukin-6 properties related to inflammatory bone resorption. However, its effects and molecular mechanism of action on osteoclastogenesis and bone resorption remain unclear. In the present study, we showed that 10 µM synthetic (+)-terrein inhibited RANKL-induced osteoclast formation and bone resorption in a dose-dependent manner and without cytotoxicity. RANKL-induced messenger RNA expression of osteoclast-specific markers including nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), the master regulator of osteoclastogenesis, cathepsin K, tartrate-resistant acid phosphatase (Trap) was completely inhibited by synthetic (+)-terrein treatment. Furthermore, synthetic (+)-terrein decreased RANKL-induced NFATc1 protein expression. This study revealed that synthetic (+)-terrein attenuated osteoclast formation and bone resorption by mediating RANKL signaling pathways, especially NFATc1, and indicated the potential effect of (+)-terrein on inflammatory bone resorption including periodontal disease.
キーワード
Synthetic (+)-terrein
Osteoclast
RANKL
NFATc1
発行日
2020-06
出版物タイトル
International Immunopharmacology
83巻
出版者
Elsevier
開始ページ
106429
ISSN
1567-5769
NCID
AA11516496
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2020 The Authors.
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionof https://doi.org/10.1016/j.intimp.2020.106429
ライセンス
http://creativecommons.org/licenses/by-nc-nd/4.0/
助成機関名
日本学術振興会
助成番号
16K11549
18K17069
オープンアクセス(出版社)
OA
オープンアーカイブ(出版社)
非OpenArchive