フルテキストURL fulltext20230828-03.pdf
著者 Al‑Hammad, Wlla| Fujikura, Mamiko| Hisatomi, Miki| Okada, Shunsuke| Munhoz, Luciana| Kawazu, Toshiyuki| Takeshita, Yohei| Fujita, Mariko| Yanagi, Yoshinobu| Asaumi, Jun-Ichi|
キーワード vascular anomalies magnetic resonance imaging computed tomography dynamic contrast-enhanced magnetic resonance imaging contrast index curve
発行日 2023-07-27
出版物タイトル Oncology Letters
26巻
3号
出版者 Spandidos Publications
開始ページ 394
ISSN 1792-1074
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 Al-Hammad et al.
論文のバージョン publisher
PubMed ID 37600333
DOI 10.3892/ol.2023.13980
Web of Science KeyUT 001049518700001
関連URL isVersionOf https://doi.org/10.3892/ol.2023.13980
JaLCDOI 10.18926/AMO/65492
フルテキストURL 77_3_273.pdf
著者 Shimizu, Yudai| Kuroda, Masahiro| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Yoshida, Suzuka| Fukumura, Yuka| Nakamura, Yoshihide| Kuroda, Kazuhiro| Kamizaki, Ryo| Imajoh, Satoshi| Tanabe, Yoshinori| Sugimoto, Kohei| Oita, Masataka| Sugianto, Irfan| Bamgbose, Babatunde O.| Yanagi, Yoshinobu| Asaumi, Junichi|
抄録 Diffusion kurtosis (DK) imaging (DKI), a type of restricted diffusion-weighted imaging, has been reported to be useful for tumor diagnoses in clinical studies. We developed a software program to simultaneously create DK images with apparent diffusion coefficient (ADC) maps and conducted an initial clinical study. Multi-shot echo-planar diffusion-weighted images were obtained at b-values of 0, 400, and 800 sec/mm2 for simple DKI, and DK images were created simultaneously with the ADC map. The usefulness of the DK image and ADC map was evaluated using a pixel analysis of all pixels and a median analysis of the pixels of each case. Tumor and normal tissues differed significantly in both pixel and median analyses. In the pixel analysis, the area under the curve was 0.64 for the mean kurtosis (MK) value and 0.77 for the ADC value. In the median analysis, the MK value was 0.74, and the ADC value was 0.75. The MK and ADC values correlated moderately in the pixel analysis and strongly in the median analysis. Our simple DKI system created DK images simultaneously with ADC maps, and the obtained MK and ADC values were useful for differentiating head and neck tumors from normal tissue.
キーワード simple diffusion kurtosis imaging mean kurtosis clinical trial head and neck tumor magnetic resonance imaging
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-06
77巻
3号
出版者 Okayama University Medical School
開始ページ 273
終了ページ 280
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37357628
Web of Science KeyUT 001026279600005
フルテキストURL isd-49-27.pdf
著者 Bamgbose, Babatunde O.| Okada, Shunsuke| Hisatomi, Miki| Yanagi, Yoshinobu| Takeshita, Yohei| Abdu, Zahrau Saleh| Ekuase, Edugie J.| Asaumi, Jun-ichi|
キーワード Tooth Supernumerary Odontoma Odontogenic Cyst
発行日 2019-05-25
出版物タイトル Imagining Science in Dentistry
49巻
1号
出版者 Korean Academy of Oral and Maxillofacial Radiology
開始ページ 27
終了ページ 34
ISSN 22337822
NCID AA12764256
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 by Korean Academy of Oral and Maxillofacial Radiology
論文のバージョン publisher
PubMed ID 30941285
DOI 10.5624/isd.2019.49.1.27
Web of Science KeyUT 000462925200004
関連URL isVersionOf https://doi.org/10.5624/isd.2019.49.1.27
著者 山中 玲子| 曽我 賢彦| 縄稚 久美子| 柳 文修| 兒玉 直紀| 中田 貴| 三浦 留美| 羽川 操| 竹内 哲男| 山根 美榮子| 森田 学| 高柴 正悟| 浅海 淳一| 皆木 省吾| 吉山 昌宏| 下野 勉| 窪木 拓男| 佐々木 朗| 森田 潔|
発行日 2009-06
出版物タイトル 岡山歯学会雑誌
28巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/52009
フルテキストURL 67_6_359.pdf
著者 Katashima, Kazunori| Kuroda, Masahiro| Ashida, Masakazu| Sasaki, Takanori| Taguchi, Takehito| Matsuzaki, Hidenobu| Murakami, Jun| Yanagi, Yoshinobu| Hisatomi, Miki| Hara, Marina| Kato, Hirokazu| Ohmura, Yuichi| Kobayashi, Tomoki| Kanazawa, Susumu| Harada, Sosuke| Takemoto, Mitsuhiro| Ohno, Seiichiro| Mimura, Seiichi| Asaumi, Junichi|
抄録 It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30sec. Heating at 42℃ was used to induce apoptosis while heating at 48℃ was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3μm. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30msec might be optimal to distinguish between apoptosis and necrosis.
キーワード ADC apoptosis necrosis hyperthermia cell density
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2013-12
67巻
6号
出版者 Okayama University Medical School
開始ページ 359
終了ページ 367
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 24356720
Web of Science KeyUT 000328915700004
著者 Kawakami, Shigehisa| Kodama, Naoki| Maeda, Naoto| Sakamoto, Shunichi| Oki, Kazuhiro| Yanagi, Yoshinobu| Asaumi, Jun-Ichi| Maeda, Teruta| Minagi, Shogo|
発行日 2012-01-15
出版物タイトル Journal of Neuroscience Methods
203巻
1号
資料タイプ 学術雑誌論文
著者 Hisatomi, Miki| Yanagi, Yoshinobu| Konouchi, Hironobu| Matsuzaki, Hidenobu| Takenobu, Toshihiko| Unetsubo, Teruhisa| Asaumi, Jun-ichi|
発行日 2011-02
出版物タイトル Oral Oncology
47巻
2号
資料タイプ 学術雑誌論文
著者 Yanagi, Yoshinobu| Fujita, Mariko| Hisatomi, Miki| Matsuzaki, Hidenobu| Konouchi, Hironobu| Katase, Naoki| Nagatsuka, Hitoshi| Asaumi, Jun-ichi|
発行日 201012
出版物タイトル Oral Radiology
26巻
2号
資料タイプ 学術雑誌論文
著者 Asaumi, Jun-ichi| Yanagi, Yoshinobu| Konouchi, Hironobu| Hisatomi, Miki| Matsuzaki, Hidenobu| Shigehara, Hiroshi| Kishi, Kanji|
発行日 2004-9
出版物タイトル European Journal of Radiology
51巻
3号
資料タイプ 学術雑誌論文
著者 Asaumi, Jun-ichi| Yanagi, Yoshinobu| Konouchi, Hironobu| Hisatomi, Miki| Matsuzaki, Hidenobu| Kishi, Kanji|
発行日 2004-7
出版物タイトル Oral Oncology
40巻
6号
資料タイプ 学術雑誌論文
著者 Maki, Yu| Murakami, Jun| Asaumi, Jun-ichi| Tsujigiwa, Hidetsugu| Nagatsuka, Hitoshi| Kokeguchi, Susumu| Fukui, Kazuhiro| Kawai, Noriko| Yanagi, Yoshinobu| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji|
発行日 2005-7
出版物タイトル Oral Oncology
41巻
10号
資料タイプ 学術雑誌論文
著者 Murakami, Jun| Asaumi, Jun-ichi| Kawai, Noriko| Tsujigiwa, Hidetsugu| Yanagi, Yoshinobu| Nagatsuka, Hitoshi| Inoue, Tetsuyoshi| Kokeguchi, Susumu| Kawasaki, Shoji| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji|
発行日 2005-07
出版物タイトル Cancer Chemotherapy and Pharmacology
56巻
1号
資料タイプ 学術雑誌論文
著者 Murakami, Jun| Asaumi, Jun-ichi| Maki, Yuu| Tsujigiwa, Hidetsugu| Kuroda, Masahiro| Nagai, Noriyuki| Yanagi, Yoshinobu| Inoue, Tetsuyoshi| Kawasaki, Shoji| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji|
発行日 2004-2
出版物タイトル Oral Oncology
40巻
6号
資料タイプ 学術雑誌論文