ID | 62458 |
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著者 |
Kataoka, Takahiro
Graduate School of Health Sciences, Okayama University
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Shuto, Hina
Graduate School of Health Sciences, Okayama University
Naoe, Shota
Graduate School of Health Sciences, Okayama University
Yano, Junki
Graduate School of Health Sciences, Okayama University
Kanzaki, Norie
Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Sakoda, Akihiro
Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Tanaka, Hiroshi
Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Hanamoto, Katsumi
Graduate School of Health Sciences, Okayama University
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Mitsunobu, Fumihiro
Graduate School ofMedicine Dentistry and Pharmaceutical Sciences, Okayama University
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Terato, Hiroaki
Advanced Science Research Center Okayama University
Yamaoka, Kiyonori
Graduate School of Health Sciences, Okayama University
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抄録 | Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m(3) (for one, three, or 10 days). The 8-hydroxy-2 '-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m(3) radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m(3) radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20-40% (2 kBq/m(3) for three days or 20 kBq/m(3) for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15-60% and 15-45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.
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キーワード | radon
oxidative DNA damage
Mn-superoxide dismutase (SOD)
8-oxoguanine DNA glycosylase
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発行日 | 2021-08-09
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出版物タイトル |
Journal of Radiation Research
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巻 | 62巻
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号 | 5号
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出版者 | Oxford University Press
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開始ページ | 861
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終了ページ | 867
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ISSN | 0449-3060
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © The Author(s) 2021.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1093/jrr/rrab069
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ライセンス | http://creativecommons.org/licenses/bync/4.0/
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オープンアクセス(出版社) |
OA
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