樋之津史郎

A Phase I Trial of 100mg/m2 Docetaxel in Patients with Advanced or Recurrent Breast Cancer

JaLCDOI	10.18926/AMO/54607
フルテキストURL	70_5_425.pdf
著者	Tamura, Tomoki\| Hirata, Taizo\| Tabata, Masahiro\| Hinotsu, Shiro\| Hamada, Akinobu\| Motoki, Takayuki\| Iwamoto, Takayuki\| Mizoo, Taeko\| Nogami, Tomohiro\| Shien, Tadahiko\| Taira, Naruto\| Matsuoka, Junji\| Doihara, Hiroyoshi\|
抄録	Docetaxel is a standard treatment for patients with advanced or recurrent breast cancer. The recommended dose is 60 to 100 mg/m2. Previous study have shown that the tumor response rates of patients who received docetaxel monotherapy at doses of 60, 75, and 100 mg/m2 were 22.1% , 23.3% , and 36.0% , respectively, and there was a significant relationship between the dose and response. In Europe and the United States, docetaxel is approved at a dose of 100 mg/m2, and Japanese guidelines also recommend a dose of 100 mg/m2. However, the approved dose in Japan is up to 75 mg/m2. We have launched a phase I trial evaluating 100 mg/m2 docetaxel in patients with advanced or relapsed breast cancer. The major eligibility criteria are as follows: age ≥20 years, pathologically diagnosed breast cancer, recurrent or advanced breast cancer, a good performance status, and HER2 [human epidermal growth factor receptor 2] negative. The primary endpoint is demonstrated safety of 100 mg/m2 docetaxel. This study will clarify whether 100mg/m2 docetaxel can be administrated safely in Japanese patients with advanced or recurrent breast cancer.
キーワード	breast cancer phase I trial docetaxel
Amo Type	Clinical Study Protocols
出版物タイトル	Acta Medica Okayama
発行日	2016-10
巻	70巻
号	5号
出版者	Okayama University Medical School
開始ページ	425
終了ページ	427
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27777441
Web of Science KeyUT	000388098700018

A Phase II Clinical Trial of the Efficacy and Safety of Short-term (3 days) Enoxaparin for the Prevention of Venous Thromboembolism after Gastric Cancer Surgery

JaLCDOI	10.18926/AMO/54601
フルテキストURL	70_5_401.pdf
著者	Kuroda, Shinji\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Hinotsu, Shiro\| Fujiwara, Toshiyoshi\|
抄録	Although intermittent pneumatic compression (IPC) has become common as perioperative prophylaxis for venous thromboembolism (VTE) consisting of pulmonary thromboembolism (PE) and deep vein thrombosis (DVT), the prophylactic effect against VTE, especially lethal PE, is not yet satisfactory. Therefore, pharmacologic prophylaxis, such as with enoxaparin, is desirable. While the efficacy and safety of enoxaparin have been proven in several clinical trials, concern about bleeding with longterm (at least 7 days) use have potentially decreased its widespread adoption. We have launched a phase II study to evaluate the efficacy and safety of short-term (3 days) enoxaparin, in which a total of 70 gastric cancer patients undergoing gastrectomy will be recruited, and the primary endpoint is the incidence of DVT. This study could contribute to making pharmacologic prophylaxis for VTE more common.
キーワード	venous thromboembolism enoxaparin short-term use gastric cancer surgery
Amo Type	Clinical Study Protocols
出版物タイトル	Acta Medica Okayama
発行日	2016-10
巻	70巻
号	5号
出版者	Okayama University Medical School
開始ページ	401
終了ページ	404
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27777435
Web of Science KeyUT	000388098700012

Efficacy and safety of scheduled early endoscopic ultrasonography‐guided ethanol reinjection for patients with pancreatic neuroendocrine tumors: Prospective pilot study

フルテキストURL	fulltext.pdf Figures.pdf Supplemental Figures.pdf
著者	Matsumoto, Kazuyuki\| Kato, Hironari\| Kawano, Seiji\| Fujiwara, Hiroyasu\| Nishida, Kenji\| Harada, Ryo\| Fujii , Masakuni\| Yoshida, Ryuichi\| Umeda, Yuzo\| Hinotsu, Shiro\| Yagi , Takahito\| Okada, Hiroyuki\|
キーワード	ethanol injection EUS‐guided therapy pancreatic neuroendocrine tumor scheduled therapy small size
備考	This is the peer reviewed version of the following article: Kazuyuki Matsumoto et. al. Efficacy and safety of scheduled early endoscopic ultrasonography‐guided ethanol reinjection for patients with pancreatic neuroendocrine tumors: Prospective pilot study. Digestive Endoscopy (2020) 32(3), 425-430, which has been published in final form at https://doi.org/10.1111/den.13552\|. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.\|
発行日	2020-03
出版物タイトル	Digestive Endoscopy
巻	32巻
号	3号
出版者	Wiley
開始ページ	425
終了ページ	430
ISSN	0915-5635
NCID	AA10907137
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	31580507
DOI	10.1111/den.13552
Web of Science KeyUT	000494577300001
関連URL	isVersionOf https://doi.org/10.1111/den.13552

Efficacy and safety of short-term (3 days) enoxaparin in preventing venous thromboembolism after gastric cancer surgery: A single-center, prospective cohort study

フルテキストURL	fulltext20210608-1.pdf highlights20210608-1.pdf figure20210608-1.pdf table20210608-1.pdf supplement20210608-1.pdf
著者	Kuroda, Shinji\| Kikuchi, Satoru\| Kakiuchi, Yoshihiko\| Watanabe, Megumi\| Kuwada, Kazuya\| Tsumura, Tomoko\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Hinotsu, Shiro\| Fujiwara, Toshiyoshi\|
備考	This is an Accepted Manuscript of an article published by Elsevier BV. © 2021 IJS Publishing Group Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ijsu.2021.105946] . \|
発行日	2021-5
出版物タイトル	International Journal of Surgery
巻	89巻
出版者	Elsevier BV
開始ページ	105946
ISSN	1743-9191
NCID	AA12063080
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 IJS Publishing Group Ltd.
論文のバージョン	author
PubMed ID	33892160
DOI	10.1016/j.ijsu.2021.105946
Web of Science KeyUT	000651625600016
関連URL	isVersionOf https://doi.org/10.1016/j.ijsu.2021.105946

ICH-GCP に準拠した臨床研究の実施とデータマネジメント

タイトル（別表記）	Data management in clinical research
フルテキストURL	129_123.pdf
著者	樋之津史郎\|
キーワード	臨床研究倫理指針 ICH-GCP
出版物タイトル	岡山医学会雑誌
発行日	2017-08-01
巻	129巻
号	2号
開始ページ	123
終了ページ	127
ISSN	0030-1558
関連URL	https://doi.org/10.4044/joma.129.123
言語	日本語
著作権者	Copyright (c) 2017 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.129.123
NAID	130006039376

Patients' acceptability and implementation outcomes of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia: a qualitative secondary analysis of a mixed-method randomised clinical trial

フルテキストURL	fulltext.pdf
著者	Yamada, Yuto\| Fujiwara, Masaki\| Shimazu, Taichi\| Etoh, Tsuyoshi\| Kodama, Masafumi\| So, Ryuhei\| Matsushita, Takanori\| Yoshimura, Yusaku\| Horii, Shigeo\| Fujimori, Maiko\| Takahashi, Hirokazu\| Nakaya, Naoki\| Miyaji, Tempei\| Hinotsu, Shiro\| Harada, Keita\| Okada, Hiroyuki\| Uchitomi, Yosuke\| Yamada, Norihito\| Inagaki, Masatoshi\|
発行日	2022-06
出版物タイトル	BMJ Open
巻	12巻
号	6号
出版者	BMJ Publishing Group
開始ページ	e060621
ISSN	2044-6055
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Author(s) (or their employer(s)) 2022.
論文のバージョン	publisher
PubMed ID	35701062
DOI	10.1136/bmjopen-2021-060621
Web of Science KeyUT	000811702800009
関連URL	isVersionOf https://doi.org/10.1136/bmjopen-2021-060621

Study about the Efficacy of Metformin to Immune Function in Cancer Patients

JaLCDOI	10.18926/AMO/54514
フルテキストURL	70_4_327.pdf
著者	Watanabe, Mototsugu\| Yamamoto, Hiromasa\| Eikawa, Shingo\| Shien, Kazuhiko\| Shien, Tadahiko\| Soh, Junichi\| Hotta, Katsuyuki\| Wada, Jun\| Hinotsu, Shiro\| Fujiwara, Toshiyoshi\| Kiura, Katsuyuki\| Doihara, Hiroyoshi\| Miyoshi, Shinichiro\| Udono, Heiichiro\| Toyooka, Shinichi\|
抄録	A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8＋ T cells, which produce multiple cytokines.
キーワード	metformin CD8＋ T cells cancer immunology
Amo Type	Clinical Study Protocols
出版物タイトル	Acta Medica Okayama
発行日	2016-08
巻	70巻
号	4号
出版者	Okayama University Medical School
開始ページ	327
終了ページ	330
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27549683
Web of Science KeyUT	000384748600018

樋之津 史郎