ID | 59939 |
フルテキストURL | |
著者 |
Tsunashima, Kenta
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Jinno, Katsuya
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Hiramatsu, Bunta
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Fujimoto, Kayo
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Sakai, Kenji
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
ORCID
Kaken ID
publons
researchmap
Kiwa, Toshihiko
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
ORCID
Kaken ID
publons
researchmap
Saari, Mohd Mawardi
Faculty of Electrical & Electronic Engineering, Universiti Malaysia Pahang
Tsukada, Keiji
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Kaken ID
researchmap
|
抄録 | Manipulation of magnetic nanoparticles (MNP) by an external magnetic field has been widely studied in the fields of biotechnology and medicine for collecting and/or reacting biomaterials in the solutions. Here, dynamic behaviors of MNP in solution under changing gradient magnetic field were investigated using our newly developed laser transmission system (LTS) with a variable magnetic field manipulator. The manipulator consists of a moving permanent magnet placed beside the optical cell filled with MNP solution. A laser beam was focused on the cell and the transmitted laser beam was detected by a silicon photodiode, so that the localized concentration of the MNP at the focused area could be evaluated by the intensity of transmitted laser beam. In this study, the LTS was applied to evaluate dynamic behaviors of MNP in serum solution. Dispersion and aggregation of MNP in the solution were evaluated. While time evolution of dispersion depends on the serum concentration, the behavior during aggregation by the magnetic field was independent of the serum concentration. A series of measurements for zeta-potentials, distributions of particle size, and magnetization distributions was carried out to understand this difference in the behavior. The results indicated that a Brownian motion was main force to distribute the MNP in the solution; on the other hand, the magnetic force to the MNP mainly affected the behavior during aggregation of the MNP in the solution.
|
発行日 | 2020-01
|
出版物タイトル |
AIP Advances
|
巻 | 10巻
|
号 | 1号
|
出版者 | AIP Publishing
|
ISSN | 2158-3226
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
OAI-PMH Set |
岡山大学
|
著作権者 | © Author(s) 2020
|
論文のバージョン | publisher
|
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1063/1.5130167
|
ライセンス | http://creativecommons.org/licenses/by/4.0/
|
助成機関名 |
文部科学省
|
助成番号 | JP15H05764
|