ID | 30510 |
JaLCDOI | |
フルテキストURL | |
著者 |
Matsuo, Kiyoshi
Okayama University
Tada, Shinya
Okayama University
Shibayama, Takuo
Okayama Univeristy
Ueno, Yoshiki
Okayama University
Miyake, Toshitugu
Okayama University
Takehara, Hideki
Okayama University
Harada, Mine
Okayama University
Kimura, Ikuro
Okayama University
|
抄録 | <P>Idiopathic interstitial pneumonia (IIP) is a progressive and often fatal pulmonary disorder, and evaluating the prognosis of patients with IIP has never been sufficient. Accordingly, factors including clinical features, laboratory data, cellular components in bronchoalveolar lavage (BAL) fluid and response to corticosteroid therapy were analyzed in 35 patients with IIP whose median age of respiratory onset was 60 years (range; 37-77 years). Nineteen patients (54.3%) were in the active stage of IIP and 16 of them were treated with corticosteroids. Significant prognostic factors were the neutrophil percentage in BAL fluid, interstitial shadows on chest radiograph, pulmonary function, blood oxygen level, grade of dyspnea, and disease activity at the initial examination. Patients in the active stage showed higher proportions of neutrophils and eosinophils in BAL fluid than those in the non-active stage. Despite corticosteroid therapy, the survival of patients in the active stage was significantly shorter than those in the non-active stage. Fifty percent of the patients treated with corticosteroids were regarded as responders at 1 month after the initiation of therapy; however, there was no significant difference between responders and non-responders in terms of survival time. In conclusion, disease activity and neutrophils in BAL fluid may be important predictors of the prognosis of IIP.</P> |
キーワード | idiopathic interstitial pneumonia (LLP)
prognostic factor
corticosteroid therapy
bronchoalveolar lavage(BAL)
disease activity
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1996-02
|
巻 | 50巻
|
号 | 1号
|
出版者 | Okayama University Medical School
|
開始ページ | 37
|
終了ページ | 46
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |