ID | 34236 |
フルテキストURL | |
著者 |
Agawa, Yasuo
Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies
Sarhan, Moustafa
The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University
Kageyama, Yuji
Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies
Akagi, Kazutaka
The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University
Takai, Masayoshi
The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University
Hashiyama, Kazuya
Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies
Wada, Tadashi
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Handa, Hiroshi
Integrated Research Institute, Tokyo Institute of Technology
Iwamatsu, Akihiro
Protein Research Network, Inc.
Hirose, Susumu
Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies
Ueda, Hitoshi
The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University
Kaken ID
publons
researchmap
|
抄録 | Regulatory mechanisms controlling the timing of developmental events are crucial for proper development to occur. ftz-fl is expressed in a temporally regulated manner following pulses of ecdysteroid and this precise expression is necessary for the development of Drosophila melanogaster. To understand how insect hormone ecdysteroids regulate the timing of FTZ-F1 expression, we purified a DNA binding regulator of ftz-fl. Mass spectroscopy analysis revealed this protein to be a fly homolog of mammalian B lymphocyte-induced maturation protein 1 (Blimp-1). Drosophila Blimp-1 (dBlimp-1) is induced directly by 20-hydroxyecdysone, and its product exists during high-ecdysteroid periods and turns over rapidly. Forced expression of dBlimp-1 and RNA interference analysis indicate that dBlimp-1 acts as a repressor and controls the timing of FTZ-F1 expression. Furthermore, its prolonged expression results in delay of pupation timing. These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway. |
キーワード | SEQUENTIAL GENE ACTIVATION
MATURATION PROTEIN-1 BLIMP-1
STEROID-RECEPTOR SUPERFAMILY
POLYTENE CHROMOSOMES
SALIVARY-GLAND
FUSHI-TARAZU
EMBRYONIC-DEVELOPMENT
MOLECULAR-MECHANISM
TEMPORAL REGULATION
STAGE SPECIFICITY
|
備考 | Published with permission from the copyright holder.
This is a author's copy,as published in Molecular and Cellular Biology , 2007 Vol.27 Issue.24 pp.8739-8747 Publisher URL: http://dx.doi.org/10.1128/MCB.01304-07 Direct access to Thomson Web of Science record Copyright © 2008 by Elsevier B.V. |
発行日 | 2008-07-06
|
出版物タイトル |
Molecular and Cellular Biology
|
巻 | 27巻
|
号 | 24号
|
開始ページ | 8739
|
終了ページ | 8747
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
査読 |
有り
|
DOI | |
Web of Science KeyUT | |
Submission Path | biochemistry/11
|