ID | 55208 |
JaLCDOI | |
フルテキストURL | |
著者 |
Washio, Kana
Department of Pediatrics, Okayama University Hospital
Muraoka, Michiko
Department of Pediatrics, National Hospital Organization Fukuyama Medical Center
Kanamitsu, Kiichiro
Department of Pediatrics, Okayama University Hospital
Oda, Megumi
Department of Pediatrics, Okayama University Hospital
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抄録 | We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH.
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キーワード | langerhans cell histiocytosis (LCH)
hemophagocytic lymphohistiocytosis (HLH)
hematopoietic stem cell transplantation (HSCT)
reduced-intensity conditioning (RIC)
refractory
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Amo Type | Case Report
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2017-06
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巻 | 71巻
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号 | 3号
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出版者 | Okayama University Medical School
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開始ページ | 249
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終了ページ | 254
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2017 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID |