start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=121 end-page=126 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=100 end-page=120 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=0n climatology in Misasa spa (twenty-1st report) kn-title=三朝温泉地の気候について(第21報) en-subtitle= kn-subtitle= en-abstract=Climatologicaldataofthelast12months (1998.1.1.-1998.12.31)obtained by the climate autorecording system at the Misasa Medical Branch in Misasa SPa,Tottori-ken, Japan are presented. kn-abstract=我々は1956年以降,三朝温泉地の気候について観察を行っている｡今回は1998年1月1日から1998年12月末日までの1年間の気象観察資料を報告する｡機器の故障により,記録の一部に欠落部分があることをお断りしておく｡ en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=InoueTaeko en-aut-sei=Inoue en-aut-mei=Taeko kn-aut-name=井上妙子 kn-aut-sei=井上 kn-aut-mei=妙子 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=光延彰子 kn-aut-sei=光延 kn-aut-mei=彰子 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=95 end-page=99 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=平成10年度看護部教育･研修･活動状況 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakamuraSumie en-aut-sei=Nakamura en-aut-mei=Sumie kn-aut-name=中村寿美江 kn-aut-sei=中村 kn-aut-mei=寿美江 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 en-keyword=看護部 kn-keyword=看護部 en-keyword=研修会 kn-keyword=研修会 en-keyword=活動 kn-keyword=活動 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=93 end-page=94 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=運動器疾患入院状況 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakamuraSumie en-aut-sei=Nakamura en-aut-mei=Sumie kn-aut-name=中村寿美江 kn-aut-sei=中村 kn-aut-mei=寿美江 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 en-keyword=看護部 kn-keyword=看護部 en-keyword=入院状況 kn-keyword=入院状況 en-keyword=運動器疾患 kn-keyword=運動器疾患 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=88 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clincal evaluation of spa effects for patients with respiratory disease and chronic pain disease kn-title=呼吸器疾患及び疼痛性疾患に対する温泉療法の臨床評価 en-subtitle= kn-subtitle= en-abstract=Clinical evaluation of spatherapy, mainly swimming and walk training in a hot spring pool and fango therapy, was performed in 158 patients (78 with respiratory disease, 64 with chronic pain disease, and 16 with other diseases) who were admitted at our hospital to receive spa therapy from January to December in 1998. The number of patients over the age of 70 was largest, and the number of patients outside Tottori prefecture (72.2%) was larger than the number inside Tottori prefecture. Spa efficacy was assessed by 5 steps according to improvement of clinical symptoms; efficacy-marked, moderate,and slight, no efficacy, and worse. Spa therapy was evaluated as effective when their symptoms were markedly or moderately improved. The spa efficacy was 72.2% at 1 month, 81.8% at 2 months, and 76.5% at 3 months after spa therapy in patients with respiratory disease. In contrast, the, efficacy was 21.1% at 1 month, 60.0% at 2 months,and 64.0% at 3 months after the therapy in patients with chronic pain disease. The efficacy was higher as the term of admission was longer in patients with chronic pain disease. kn-abstract=1998年1月より12月までの1年間に,温泉療法-主として温泉プール水泳ないし歩行訓練及び鉱泥湿布治療-を受けた158例の入院症例(呼吸器疾患78例,疼痛性疾患64例,その他16例)について退院時に臨床効果を5段階で評価してもらいそれぞれの入院期間との比較検討を行った｡対象症例の年齢は70才代が最も多く,次いで60才代,50才代,80才代であった｡地域分布では,鳥取県外の入院症例が72.2%を占め,県外である遠隔地としては,岡山県,兵庫県,広島県,大阪府,東京都,神奈川県からの入院が多く見られた｡臨床効果は,"非常に良くなった"と,"かなり良くなった"を有効と判定し,その有効率は呼 吸器疾患では78.2%であった｡一方,疼痛性疾患では,その有効率は50.0%であったが,"少し良くなった"症例を含めると,95.3%,その他の症例は68.8%であった｡入院期間別に検討すると,呼吸器疾患では入院1ケ月で72.7%,2ケ月では81.8%,3ケ月以上では76.5%であった｡一方,疼痛性疾患では,入院1ケ月で21.1%,2ケ月で60.0%,3ケ月で64.0%であり,呼吸器疾患と比べ,効果出現までの期間がやヽ長く,入院期間が長くなるほど,その効果は高くなる傾向が見られた｡ en-copyright= kn-copyright= en-aut-name=NishimuraNobuko en-aut-sei=Nishimura en-aut-mei=Nobuko kn-aut-name=西村伸子 kn-aut-sei=西村 kn-aut-mei=伸子 aut-affil-num=1 ORCID= en-aut-name=TerasakiKayo en-aut-sei=Terasaki en-aut-mei=Kayo kn-aut-name=寺崎佳代 kn-aut-sei=寺崎 kn-aut-mei=佳代 aut-affil-num=2 ORCID= en-aut-name=YamamotoSadae en-aut-sei=Yamamoto en-aut-mei=Sadae kn-aut-name=山本貞枝 kn-aut-sei=山本 kn-aut-mei=貞枝 aut-affil-num=3 ORCID= en-aut-name=NakamuraSumie en-aut-sei=Nakamura en-aut-mei=Sumie kn-aut-name=中村寿美江 kn-aut-sei=中村 kn-aut-mei=寿美江 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=呼吸器疾患 (respiratory disease) kn-keyword=呼吸器疾患 (respiratory disease) en-keyword=慢性疼痛性疾患 (chronic pain disease) kn-keyword=慢性疼痛性疾患 (chronic pain disease) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=84 end-page=87 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Interferon and pancreatitis kn-title=膵炎とインターフェロン en-subtitle= kn-subtitle= en-abstract=Pancreatitis is known to be one of the adverse effects of interferon, which has been widely used for treatment of chronic hepatitis and malignant diseases. In this paper, we reviewed pancreatitis as adverse effects of interferon and effect of interferon on the pancreas. kn-abstract=インターフェロンは慢性肝炎や悪性腫瘍の治療など,広く臨床の場に用いられるようになった｡その副作用の一つとして,膵炎があり,その多くは急性膵炎である,慢性膵炎の報告もあり,膵炎はインターフェロンを用いる場合に知っておくべき副作用である｡そこで,膵炎とインターフェロンの関係について現在までに知られている知見について概説する｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=勝山病院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=インターフェロン (interferon) kn-keyword=インターフェロン (interferon) en-keyword=急性膵炎 (acute pancreatitis) kn-keyword=急性膵炎 (acute pancreatitis) en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=79 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=臨床的および実験的側面からみた慢性膵炎とフリーラジカル kn-title=Clinical and experimental aspects of free radicals in chronic pancreatitis en-subtitle= kn-subtitle= en-abstract=慢性肺炎の発症機序は不明な点が多いが､フリーラジカルがそれに関与することが示唆する報告も多い｡しかし,その直接的な証明はなされていない｡慢性膵炎の病態にフリーラジカルがどのように関与するかを理解することは慢性膵炎の発症機序の解明の一助になると考え,臨床的および実験的側面から慢性膵炎とフリーラジカルの関係を概説した｡ kn-abstract=Free radicals have been suspected to play an important role in the pathogenicity of chronic pancreatitis. We reviewed studies on free radicals in chronic pancreatitis in both c1inical and experimental aspects. Many clinical studies have provided circumstantial evidence for the close relation between free radicals and chronic pancreatitis. However, few experimental studies in animals on relation between free radicals and chronic pancreatitis have been reported, because adequate experimental models for elucidating a pathological role of free radicals in chronic pancreatitis have not been established. The research concerning the role of free radicals in chronic pancreatitis is expected to improve our understanding the pathological mechanisms of the disease. en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=フリーラジカル (free radicals) kn-keyword=フリーラジカル (free radicals) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=73 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of Factors Regarding Spa Therapy in Patients with Rheumatoid Arthritis kn-title=慢性関節リウマチ患者の温泉治療効果に関する要因の分析 en-subtitle= kn-subtitle= en-abstract=In patients with rheumatoid arthritis (RA) who received spa therapy (ST) on admission, we examined factors for treatment response. This study included 6 RA patients and the following 4 parameters were investigated: presence or absence of previous ST, age, duration of RA, and grade of the functional disorder. Treatment response was evaluated according to the American College of Rheumatology core set measures. With respect to the presence or absence of previous ST, modified health assessment questionnaire (MHAQ), pain scale and patient global assessments in the group with previous ST were significantly improved compared to those in the group without previous ST. With respect to age, MHAQ in the group consisting of patients less than 75 years old was significantly improved compared to that in the group consisting of patients 75 years old or older. With respect to the grade of the functional disorder (class 2 or lower vs. class 3 or higher) and the duration of RA (less than 15 years vs. 15 years or more), there were no significant differences. These results suggest that repeated therapy is more effective in ST and treatment response may be relatively poor in elderly patients with RA aged over 75 years. kn-abstract=1998年4月より9月までの6ヶ月間に当院へ入院し温泉療法をうけた慢性関節リウマチ患者6例を対象に,温泉治療経験の有無,年齢,機能障害度(クラス),罹患年数の4項目が温泉療法効果に及ぼす影響につき検討した｡温泉治療経験の有無では治療経験を有する患者においてMHAQ(modified health assessment questionnaile),患者による疼痛評価,患者による全般活動性評価に有意な改善が見られ,年齢(75才以上,75才未満)では,75才未満においてMHAQに有意な改善傾向が見られた｡機能障害度(クラス3以上,クラス2以下),罹患年数(15年以上,15年未満)においては有意差は見られなかった｡温泉の永続効果を保つためには,年1～2回の入院を繰り返すことが効果的であることが示唆された｡ en-copyright= kn-copyright= en-aut-name=YoshioKeiko en-aut-sei=Yoshio en-aut-mei=Keiko kn-aut-name=吉尾慶子 kn-aut-sei=吉尾 kn-aut-mei=慶子 aut-affil-num=1 ORCID= en-aut-name=TagumaMasae en-aut-sei=Taguma en-aut-mei=Masae kn-aut-name=田熊正栄 kn-aut-sei=田熊 kn-aut-mei=正栄 aut-affil-num=2 ORCID= en-aut-name=NoumiMayumi en-aut-sei=Noumi en-aut-mei=Mayumi kn-aut-name=能見真由美 kn-aut-sei=能見 kn-aut-mei=真由美 aut-affil-num=3 ORCID= en-aut-name=NakamuraSumie en-aut-sei=Nakamura en-aut-mei=Sumie kn-aut-name=中村寿美江 kn-aut-sei=中村 kn-aut-mei=寿美江 aut-affil-num=4 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=慢性関節リウマチ kn-keyword=慢性関節リウマチ en-keyword=温泉療法 kn-keyword=温泉療法 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=67 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=腰椎MRI画像と腰痛の関係 kn-title=The relationship between the magnetic resonance imaging of the lumbar spine and low back pain en-subtitle= kn-subtitle= en-abstract=この研究の目的は腰痛評価におけるMRIの役割を検討することであった｡対象は腰痛を訴え腰椎MRIを受けた19名(32歳から39歳2名,59歳から78歳17名)であった｡椎間板変成はL4/5levelで最も多く認められた(68.4%)｡本研究において腰痛を有する全患者に腰椎の異常(椎間板変性,disc bulging, protrusion, facet hypertrophy,神経根圧迫,腰椎変形など)を認めた｡ kn-abstract=The purpose of this study was to examine the potential role of magnetic resonance imaging (MRI) in the evaluation of low back pain (LBP). The study group, 19 patients with low back pain (2 subjects aged 32-39 years and 17 aged 59-78), underwent MRI of the lumbar spine. Disc degeneration at L4/5 was the most common finding (68.4%). Overall in present study, all patients with LBP had abnormalities around the lumbar spine (evidence of disc degeneration, deformity of lumbar spine, disc bulging or protrusion, facet hypertrophy, nerve root compression and so on). en-copyright= kn-copyright= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=1 ORCID= en-aut-name=YumotoEiichirou en-aut-sei=Yumoto en-aut-mei=Eiichirou kn-aut-name=湯本英一朗 kn-aut-sei=湯本 kn-aut-mei=英一朗 aut-affil-num=2 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=3 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=4 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=5 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=6 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=MRI (Magnetic resonance imaging) kn-keyword=MRI (Magnetic resonance imaging) en-keyword=腰椎 (Lumbar spine) kn-keyword=腰椎 (Lumbar spine) en-keyword=椎間板変性 (Disc disease) kn-keyword=椎間板変性 (Disc disease) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=61 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Case of Recurrent Churg-Strauss Syndrome Associated with Bronchial Asthma kn-title=Churg-Strauss症候群の再燃を来した気管支喘息症例 en-subtitle= kn-subtitle= en-abstract=A recurrent case of Churg-Strauss syndrome (CSS) associated with bronchial asthma is reported. A 73-year-old woman with bronchial asthma was admitted to our hospital because of persistent sensory disturbance of the bilateral lower limbs. About 2 weeks or more after admission, slight fever and an unpleasant sensation in the lower abdomen appeared and continued. Several days later, drop foot and melena developed. The eosinophil count was markedly increased and the endoscopic examination revealed rectal ulcers. Since the patient had a same experience of these symptoms three years ago, the recurrence of CSS was strongly suggested. Immediately after steroid treatment was started, these newly developed symptoms were relieved with no segulae. We reported the present case, which may be useful for clarifying the onset of CSS, with a review of the literature. kn-abstract=入院中にChurg-Strauss症候群の再燃を来した症例を報告した｡症例は気管支喘息を有する73歳の女性で,持続する両下肢の知覚障害を主訴に当院に入院した｡入院2週頃より微熱,下腹部不快感が続き右下肢のdrop foot,下血を呈した｡末梢血では著明な好酸球増多を認め,内視鏡検査で直腸潰瘍を認めた。3年前の両下肢の知覚障害出現時にも同様の症状を経験しており,Churg-Strauss症候群の再燃と診断し,ステロイド治療を開始することにより新たな後遺症を残すことなく寛解に至った｡Churg-Strauss症候群の発症･再燃の機序を考える上で貴重な症例と考え,文献的考察を加え報告する｡ en-copyright= kn-copyright= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=1 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=8 ORCID= en-aut-name=YamamotoToshio en-aut-sei=Yamamoto en-aut-mei=Toshio kn-aut-name=山本敏雄 kn-aut-sei=山本 kn-aut-mei=敏雄 aut-affil-num=9 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=野島病院外科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=Churg-Strauss症候群 (Churg-Strauss syndrome) kn-keyword=Churg-Strauss症候群 (Churg-Strauss syndrome) en-keyword=アレルギー性肉芽腫性血管炎 (allergic granulomatous angiitis) kn-keyword=アレルギー性肉芽腫性血管炎 (allergic granulomatous angiitis) en-keyword=血管炎症候群 (vasculitis syndrome) kn-keyword=血管炎症候群 (vasculitis syndrome) en-keyword=気管支喘息 (bronchial asthma) kn-keyword=気管支喘息 (bronchial asthma) en-keyword=好酸球増多 (eosinophilia) kn-keyword=好酸球増多 (eosinophilia) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=53 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息症例における皮質骨海綿化 kn-title=Cortical bone porosity in patients with asthma en-subtitle= kn-subtitle= en-abstract=【目的】これまでに我々は,気管支喘息症例において経口ステロイドによる皮質骨骨密度,容積の減少が骨折に関与する新知見を報告し,閉経後女性では皮質骨骨密度一容積の減少はステロイド投与量にかかわらず一定であることを報告してきた｡この皮質骨骨密度-容積の関係において性差による違いを検討するために,男性,女性患者の両方について検討を行った｡【方法】対象はステロイド依存性喘息99例(男性26例,女性73例)｡性別,年齢,経口ステロイド積算総投与量により6群に分類した｡椎体圧迫骨折はⅩ線側面像にて評価 し,皮質骨容積比および皮質骨骨密度はpQCT(Stratec XCT960)を用いて測定した｡それぞれの群の皮質骨骨密度-容積比の関係を算出し比較検定をおこなった｡【結果】それぞれの群の皮質骨の骨密度と容積比は有意に相関した｡それぞれの群の皮質骨骨密度-容積比の傾きは,いずれも有意差を認めなかった｡【結論】気管支喘息症例におけるステロイド投与による皮質骨の骨密度と容積の減少は,性別にかかわらずほぼ一定で,皮質骨は内側と外側において同様に海綿化してゆくと考えられた｡ kn-abstract=In previous studies, we have demonstrated that chronic administration of systemic glucocorticoids decreases cortical bone mineral density (BMD), cortical bone volume, bone strength, and induces development of pathologic fractures in asthmatic patients. We have also demonstrated that glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites in postmenopausal asthmatic patients. There is a difference of gonadal hormones between male and female. To investigate the influence of hormonal difference on glucocorticoid-induced cortical bone porosity, we studied cortical bone volume and BMD in both male and female patients with asthma in this report. A total of 99 asthmatic patients (male 26 cases, female 73 cases) were enrolled in the study. Peripheral quantitative computed tomography (pQCT) was used to measure cortical BMD and relative cortical volume. The cortical volume-density relationship appeared to remain constant regardless of the level of systemic glucocorticoid administration, age or sex, suggesting cortical bone porosity causes similar and simultaneous decreases in cortical bone volume and density. In conclusion, glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites despite the gonadal hormonal differences. en-copyright= kn-copyright= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=1 ORCID= en-aut-name=NakaiMutsuro en-aut-sei=Nakai en-aut-mei=Mutsuro kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=2 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=3 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=4 ORCID= en-aut-name=TakataShingo en-aut-sei=Takata en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=5 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=8 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=9 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=10 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一内科 affil-num=12 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=systemic glucocorticoid kn-keyword=systemic glucocorticoid en-keyword=cortical bone kn-keyword=cortical bone en-keyword=cortical porosity kn-keyword=cortical porosity en-keyword=peripheral quantitative computed tomography kn-keyword=peripheral quantitative computed tomography END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=43 end-page=52 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者における白血球ロイコトリエン産生能に対する不飽和脂肪酸食の効果に影響する因子 kn-title=Factors influencing the effects of dietary supplementation　with PUFAs on leukotriene generation by leucocytes in　patients with asthma en-subtitle= kn-subtitle= en-abstract=a-リノレン酸の豊富なエゴマ油の食事は気管支喘息患者の白血球ロイコトリエン(LT)産生能を抑制する｡気管支喘息患者の内,エゴマ油食によりLTC4の産生が抑制された群(A群)と抑制されない群(B群)の臨床データを比較することにより,気管支喘息患者の白血球ロイコトリエン産生能に影響する因子を検討した｡A群はコーン油(n-6系脂肪酸)の豊富な食事後,白血LTB4,LTC4の産生能が増加し,エゴマ油(n-3系脂肪酸)の豊富な食事後LTB4,LTC4の産生能が減少した｡これらの変化はB群では認められなかった｡A群のIgE値,ピークフロー(PEF)値はB群に比し,有意に高値であった｡またLDL-コレステロール,β-リポ蛋白,リン脂質はA群ではB群に比し,有意に低値であった｡これらの結果はエゴマ油の豊富な食事のn-3系脂肪酸によるLTB4,LTC4の産生能の抑制に関して2群の気管支喘息患者群間に臨床データの相違があることを示唆している｡ kn-abstract=Dietary supplementation with perilla seed oil, a vegetable oil rich in α -lin- olenic acid, inhibits the generation of leukotrienes(LTs) by leucocytes in patients with bronchial asthma. We examined the factors that affect the suppression of LT generation by leucocytes with perilla seed oil-rich supplementation in patients with asthma, by comparing the clinical features of patients with asthma, whose generation of leukotriene (LT) C4 was suppressed by dietary supplementation with perilla seed oil (n-3 fatty acids) (group A), with those of patients who showed no suppression of LTC4 generation (group B). Group A showed a significant increase in the generation of LTB4 and L TC4 by leucocytes after corn oil-rich supplementation (n-6 fatty acids), and a significant decrease in the generation of LTB4 and LTC4 after perilla seed oil-rich supplementation (n-3 fatty acid). However, this was not observed in group B. The level of serum IgE and peak expiratory flow (PEF) in group A were significantly higher than in group B. Furthermore, the serum levels of LDL-cholesterol, β-lipoprotein and　phospholipid were significantly lower in group A than in group B. These results suggest that the clinical features differ between these two asthmatic populations with respect to suppression of LTB4 and LTC4 generation by n-3 fatty acids in perilla seed oil-rich supplementation. en-copyright= kn-copyright= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=HaradaSeishi en-aut-sei=Harada en-aut-mei=Seishi kn-aut-name=原田誠之 kn-aut-sei=原田 kn-aut-mei=誠之 aut-affil-num=7 ORCID= en-aut-name=TakadaShingo en-aut-sei=Takada en-aut-mei=Shingo kn-aut-name=高田真吾 kn-aut-sei=高田 kn-aut-mei=真吾 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=KataokaMikio en-aut-sei=Kataoka en-aut-mei=Mikio kn-aut-name=片岡幹男 kn-aut-sei=片岡 kn-aut-mei=幹男 aut-affil-num=10 ORCID= en-aut-name=NiiyaKenji en-aut-sei=Niiya en-aut-mei=Kenji kn-aut-name=新谷憲治 kn-aut-sei=新谷 kn-aut-mei=憲治 aut-affil-num=11 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=12 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=エゴマ油 (perilla seed oil) kn-keyword=エゴマ油 (perilla seed oil) en-keyword=気管支喘息 (bronchial asthma) kn-keyword=気管支喘息 (bronchial asthma) en-keyword=ロイコトリエン (leukotrienes) kn-keyword=ロイコトリエン (leukotrienes) en-keyword=IgE kn-keyword=IgE en-keyword=脂質代謝 (lipometabolism) kn-keyword=脂質代謝 (lipometabolism) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=36 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=サーモグラフィーによる体表面温度の測定 3.体表面温度の回復率と末消血流量との相関 kn-title=Evaluation of Body Surface Temperature by Thermography 3. Correlation between the peripheral circulation estimatedby Laser-Doppler blood flowmetry and thermography. en-subtitle= kn-subtitle= en-abstract=末梢神経障害を有する糖尿病患者の末梢循環障害の程度を数量的に検討する目的で､下肢に冷感ならびにしびれ感または疼痛を訴える糖尿病患者9症例と健常ボランティア3例の計12例(平均年齢59歳)についてサーモグラフィーを用いて体表面温度を測定した｡更に,サーモグラフィーで得られた結果と末梢皮膚血流量をレーザードプラー血流計を用いて測定して得られた結果と比較した｡サーモグラフィーによる測定で得られた結果は回復率として数量化して表示された｡回復率の算出方法は回復率= [冷水負荷後の特定温度27℃以 上の体表面温度のサーモグラフィーのPixelの総数]÷ [冷水負荷前の特定温度27℃以上の体表面温度のサーモグラフィーのPixelの総数]×100%で求めた｡レーザードプラ-血流計を用いて測定して得られた末梢血流量は左右それぞれ5カ所,計10カ所の測定値の平均で表示した｡その結果,末梢皮膚温度の回復率と末梢皮膚の血流量との問には正の相関関係(r=0.68,p<0.01)が認められた｡次に,末梢皮膚血流量について,室温20℃安静15分後,温水36℃浸水負荷10分後,冷水20℃浸水負荷30分後の異なる3条件について､またサーモグラフィーで得られた結果を,画像処理の過程で用いられた,26℃,27℃,28℃の3つの異なる特定温度との関連について検討を行なった｡対象は,下肢に冷感ならびにしびれ感または疼痛を訴える糖尿病患者16症例(平均年齢69歳,平均HbAIC9.6%)について測定した｡その結果,末梢皮膚 血流量は冷水20℃浸水負荷30分後に測定して得られた結果と,回復率は特定温度27℃で画像処理して得られた結果とが最も相関が高い(r=0.59,p=0.0002)ことが示された｡`次に,相関が高い条件は,室温20℃安静15分後に血流量を測定した場合(r=0.483,p=0.0002)であった｡そして温 水36℃浸水負荷10分後に測定して得られた結果とが最も相関関係が低い結果となった｡更に,冷水20℃浸水負荷30分後に測定して得られた結果を温水36℃浸水負荷10分後に測定して得られた結果で割った比を%で表示したところ回復率とこの比との間には正の相関関係(r=0.46,p<0.0001)が認められた｡このことから,温水36℃負荷時と,冷水20℃負荷時との差が大きい患者 において末梢皮膚温度の低下が著しいことが示された｡これまで悲観血的に測定されてきたサーモグラフィーによる末梢循環の数量的評価の試みは,レーザー血流計による結果と組み合わせることで,両者の間に正の相関関係が示されたことにより,今後,数量化された客観的評価を可能にした｡ kn-abstract=The body surface peripheral circulation in 12 cases,　including 9 patients with　diabetes mellitus who were suffering coldness, numbness or pain in their feet, and 3 healthy volunteers was examined using Laser-Doppler blood flowmetry. At the same time, the body surface temperature was estimated by thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio = [Total counts of thermography(Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). The recovery ratio and the blood flow were correlated, r=0.68, p