start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=英文目次・裏表紙 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=投稿規定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ステロイド依存性重症難治性喘息に対する温泉療法の遠隔効果 kn-title=Distant effects of spa therapy on steroid-dependent intractable asthma en-subtitle= kn-subtitle= en-abstract=67例のステロイド依存性重症難治性喘息を対象に，温泉療法を行い，その即時的効果（1週間後）および遠隔効果（1年後），さらには，温泉療法後の継続療法の影響などについて検討を加えた。1．温泉療法1週間後の即時的効果は比較的高く，その有効率は，Ta．気管支攣縮型で61.5％，Tb．気管支攣縮＋過分泌型で82.7％，U．細気管支閉塞型で83.4％であった。2．温泉療法の遠隔効果では，その有効率は，Ta型で50.2％，Tb型で54.1％，U型で63.7％であった。3．温泉療法の遠隔効果は，その後の継続療法の有無によりかなり異なった結果であった。すなわち，継続療法を行った症例の有効率は，72.8〜91.7％と高く，一方，継続療法を行わなかった症例の有効率は，16.7〜40.0％の間にあった。これらの結果から，温泉療法の即時的効果を保つためには，その後の継続療法が極めて重要であることが示唆された。 kn-abstract=The immediate effects (IEs) and distant effects (DEs) of spa therapy were observed in 67 patients with steroid- dependent intractable asthma (SDIA). (1) The IEs of spa therapy evaluated one week after spa therapy were considerably high, and the efficacy rate was 61.5% in type Ta, 82.7% in type Tb, and 83.4% in type U asthmatics. (2) The DEs of spa therapy on SDIA were also observed. The efficacy rate was 50.2% in type Ta, 54.3% in type Tb and 63.7% in type U asthmatics. (3) The DEs　of spa therapy were different between cases with and without maintenance therapy (MT).　The efficacy rate of DEs was generally high (72.8〜91.7%) in cases with MT, and low (16.7〜40.0%) in cases without MT. These results show that MT is very important to keep the IEs of spa therapy high for a long time. en-copyright= kn-copyright= en-aut-name=TanazakiYoshiro en-aut-sei=Tanazaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=6 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=7 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院第二内科 en-keyword=lmmediate effects (即時的効果) kn-keyword=lmmediate effects (即時的効果) en-keyword=Distant effects (遠隔効果) kn-keyword=Distant effects (遠隔効果) en-keyword=Maintenance therapy (継続療法) kn-keyword=Maintenance therapy (継続療法) en-keyword=Spa therapy (温泉療法) kn-keyword=Spa therapy (温泉療法) en-keyword=Steroid-dependent intractable asthma (ステロイド依存性重症難治性喘息) kn-keyword=Steroid-dependent intractable asthma (ステロイド依存性重症難治性喘息) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=23 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical aspects of chronic obstructive lungdisease with small airways obstruction. -Comparison between bronchial asthma and chronic obstructive bronchiol itis- kn-title=細気管支領域に病変を有する慢性閉塞性呼吸器疾患の臨床的検討 en-subtitle= kn-subtitle= en-abstract=Subjects with bronchial asthma with bronchiolar obstruction (type II) and cases with chronic obstructive bronchiolitis (COB) were compared by clinical characteristics and ezaminations. (1) The mean age was slightly younger in cases with COB than in asthma cases. The mean age at onset was slightly younger in asthma cases than in cases with COB. (2) The cases with asthma showed positive immediate allergic reactions. However the cases with COB didnot show any positive reactions. (3) The frequency of neutro phils in BALF was significantly higher in the cases with COB than in the cases with asthma. The majority of cases with COB showed the high frequency of neutrophils more than 55% in BALF. (4) In the ventilatory function tests the values of % FVC and FEV(1.0%) were not different between the cases with asthma and the cases with COB. The values of % V(50) and % V(25) which represent small airway obstruction were slightly more decreased in cases with asthma than in the cases with COB. (5) Any abnormalities in roentgenograms of the cases with asthma were not distinctly observed, while the cases with COB showed overinflation and diffuse small round opacities. kn-abstract=細気管支に病変を有すると考えられる気管支喘息（細気管支閉塞型（II型）のアトピー型）と慢性閉塞性細気管支炎の違いについて臨床的に検討を加えた。(1)年令ではやや慢性閉塞性細気管支炎でやや低年令，発症年令では気管支喘息でやや低年令を示したが有意な差はみられなかった。(2)アレルギー学的検討では気管支喘息は明らかに1型アレルギー反応の関与が推測されたが，一方慢性閉塞性細気管支炎では1型アレルギー反応の関与はほとんどみられなかった。(3)Bronchoaiveolar lavage fluid（BALF）中出現細胞の検討では慢性閉塞性細気管支炎において気管支喘息に比べ好中球の有意の増加が観察され，出現率が55％以上の症例ではほぼ全例が慢性閉塞性細気管支炎であった。(4)換気機能による検討では％肺活量，1秒率では差は認められなかったが，気管支喘息で％V50，％V25のような細気管支の閉塞を示すパラメーターの低下傾向がやや高度であった。(5)胸部X線では気管支喘息では，X線上明らかなび四三陰影は認められず，一方慢性閉塞性細気管支炎では過膨脹所見も，び漫性情粒状陰影ともみられる症例が多く認められた。 en-copyright= kn-copyright= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=3 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=細気管支 (Bronchiole) kn-keyword=細気管支 (Bronchiole) en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=細気管支閉塞型 (Bronchiolar obstruction type) kn-keyword=細気管支閉塞型 (Bronchiolar obstruction type) en-keyword=慢性閉塞性細気管支炎 (Chronic obstructive bronchiolitis) kn-keyword=慢性閉塞性細気管支炎 (Chronic obstructive bronchiolitis) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=73 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Re-evaluation of spa-drink therapy for digestive diseases kn-title=消化器疾患における飲泉療法の再評価 en-subtitle= kn-subtitle= en-abstract=With the advent of new instruments for examining the digestive organs, we have attempted to re-evaluate the efficacy and indications of spa-drink therapy for digestive diseases. This report deals with an overview of the results we have obtained so far. Effect of oral intake of thermal water (Misasa thermal water, 38-42℃, 150-200 ml) on gastric mucosal blood flow was evaluated, using an endoscopic organ reflex spectrophotometry together along with an Olympus XQ - 10 forward viewing gastrofiberscope. Single intake of thermal water as well as long-term spa-drink therapy (two times a day between meals for more than two weeks) brought about an improvement of gastric mucosal blood flow. Gastric emptying function was evaluated with an acetaminophen method. Single intake of thermal water brought about disordered gastric emptying (excessively accelerated or suppressed). However, long-term spa-drink therapy brought about an improvement (normalization) of gastric emptying function. Exocrine pancreatic function was evaluated with a synthetic peptide, N-BT-PABA, and also by measuring fecal chymotrypsin actIvIty. Longterm spa-drink therapy brought about an improvement of exocrine pancreatic function. Motility of the gall-bladder was evaluated by abdominal ultra-sonography. Long-term spa-drink therapy gave no effect on the motility of the gallbladder. In conclusion, our recent study indicate that : (1) single oral intake of thermal water as well as longterm spa-drink therapy is effective for gastric diseases related to decreased gastric mucosal blood flow (treatment of intractable peptic ulcer and chronic gastritis, and prevention of recurrence of peptic ulcer) ; (2) long-term spa-drink therapy is effective for dyspepsia syndrome; (3) long-term spa-drink therapy is effective as a supplemental method in the treatment of exocrine pancreatic dysfunction (chronic pancreatitis) ; (4) thermal water should be taken between meals. kn-abstract=従来飲泉などの温泉治療は経験的知識にもとづいて行われる部分が多かったが，今後は科学的検査法を用いて有用性，適応疾患，適応病態，などを決定する必要がある。筆者らは，最近紹介された簡便な消化器検査法を用いて消化器疾患に対する飲泉療法の適応を再吟味しているので，これまでに得られた成績を中心に概説した。すなわち，(1)飲泉は1回でも連日の飲用でも，胃粘膜血流を改善する作用がある。(2)胃排出機能に対しては調整的効果を有する。(3)連日の飲泉は膵外分泌機能を改善する。したがって慢性の胃，膵疾患において粘膜血流障害，胃運動機能異常あるいは膵外分泌機能低下に起因する病気・病態に対しては積極的に飲泉療法を試みるべきである。温泉水の温度は40℃前後，飲泉の量は150〜200ml，タイミングは食間空腹時がよい。 en-copyright= kn-copyright= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=飲泉療法 (Spa-drink therapy) kn-keyword=飲泉療法 (Spa-drink therapy) en-keyword=消化器機能 (Digestive function) kn-keyword=消化器機能 (Digestive function) en-keyword=胃粘膜血流 kn-keyword=胃粘膜血流 en-keyword=胃排出能 kn-keyword=胃排出能 en-keyword=膵外分泌 kn-keyword=膵外分泌 en-keyword=胆嚢機能 kn-keyword=胆嚢機能 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=41 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Maternity swimming at Misasa Hospital of Okayama University Medical School. -Third report. The physiological changes before and after the maternity swimming- kn-title=岡山大学医学部三朝分院における妊婦水泳 ―第三報，妊婦水泳が母児の循環器系に与える影響について― en-subtitle= kn-subtitle= en-abstract=The physiological changes before and after the maternity swimming were retrospectivelly analyzed in 151 records. Following findings were observed after maternity swimming: 1. An increase in maternal pulse rate was observed in 116 cases (76.8%) out of all the cases. 2. Maternal blood pressure increased in 81 cases (53.6%) and decreased in 60 cases (39.7%). 3. An Increase In baseline of fetal heart rate was found in 92 cases (60.9%). 4. Long term variability (LTV) decreased in 67 case s (44.3%) and increased in 21 cases (13.9%). 5. The number of cases with increased fetal movement was almost similar to the number of cases with decreased movement. 6. The rate of uterine contraction increased in 66 cases (43.7%), but there were no cases to need any treatment. The conclusion was as follows: 1. No dangerous changes were observed in non stress test (NST), maternal pulse rate and maternal blood pressure. 2. The increase of baseline of fetal heart rate and the decrease of LTV were characteristic changes of NST after the maternity swimming. kn-abstract=第一報において妊婦水泳に関する妊婦の認識について報告し，第二報において妊婦水泳の現状とその適応について報告したが，その後も症例は順調に増加しており，現在までの参加人数は49名に達した。今回は妊婦水泳が母体と胎児の循環器系にどのような影響を与えるかを調べるために，妊婦水泳の前後におけるnon stress test（NST）と母体の血圧と脈拍数の変化を分析した。対象は妊娠5カ月以降の21名の正常妊婦とした。1．母体の脈拍数は水泳後に増加するものが約80％と明らかに多かったが，血圧は水泳前後で大きな差はみられなかった。2．NSTでは，水泳後に胎児基準心拍数の増加するものが妊娠中期で55.2％，後期で62.3％と多かった。胎児心拍数のlong term variability（LTV）は水泳後に減少するものが妊娠後期で 48.4％を占めた。3.胎動回数は水泳前後でほぼ一定であった。腹緊回数が水泳後に増加した例が妊娠後期で42.4％を占めた。これらの結果のうち，水泳後の胎児基準心拍数の増加とLTVの減少について生理学的見地より若干の考察を加えた。 en-copyright= kn-copyright= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=1 ORCID= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=2 ORCID= en-aut-name=KondouYuuji en-aut-sei=Kondou en-aut-mei=Yuuji kn-aut-name=近藤裕司 kn-aut-sei=近藤 kn-aut-mei=裕司 aut-affil-num=3 ORCID= en-aut-name=SakataJunnko en-aut-sei=Sakata en-aut-mei=Junnko kn-aut-name=坂田旬子 kn-aut-sei=坂田 kn-aut-mei=旬子 aut-affil-num=4 ORCID= en-aut-name=YoshidaSachie en-aut-sei=Yoshida en-aut-mei=Sachie kn-aut-name=吉田佐智江 kn-aut-sei=吉田 kn-aut-mei=佐智江 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=妊婦水泳 (Maternity swimming) kn-keyword=妊婦水泳 (Maternity swimming) en-keyword=胎児心拍数 (Fetal heart rate) kn-keyword=胎児心拍数 (Fetal heart rate) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=36 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical study on polypoid lesions of the colon kn-title=大腸ポリープの臨床的検討 en-subtitle= kn-subtitle= en-abstract=This report is concerned with clinical study on 90 patients with polypoid lesions (107 lesions) which we have encountered in Misasa Hospital, Okayama University in the past 4 years. Following results were obtained : (1) Polypoid lesions were detected in 90 (22.4%) and advanced adenocarcinoma (mostly resectable) in 22 (5.5%) of 402 patients who were examined by sigmoidoscopy and barium enema ; (2) Histological examination of the polypoid lesions showed adenoma in 77.2%, hyperplastic polyp in 8.7%, inflammatory polyp in 7.6%, neurinoma in 0.3% and early cancer (adenocarcinoma) in 5.4% ; (3) It was impossible to differentiate benign and malignant polypoid lesions on the basis of endoscopic and X-ray findings alone ; (4) Forty-two percent of the polypoid lesions was detected in the sigmoid colon, 30% in the rectum, 16.8% in the descending colon, 9.3% in the ascending colon, 0.9% in the caecum ; (4) Patients younger than 50 years of age showed only one polypoid lesion in the right hemicolon, whereas elder patients showed as many as 17 polypoid lesions ; (5) Among the 90 patients with polypoid lesions, 40 presented with abdominal pain, 20 with no symptoms (annual health check-up), 17 with irregular bowel habits, and 10 with melena ; (6) Among the 90 patients, occult blood in stool was positive in 75.8% with a lower positive rate in the lesions of the sigmoid and rectum ; (7) Among 5 asymptomatic patients with lesions and with a negative hemoccult test, 3 patients with a polypoid lesion were examined because of the patients' request, 1 patient with a polypoid lesion because of a positive family history, and the remaining 1 patient in a search for the primary lesion of the metastatic liver cancer ; (8) Among patients with a positive hemoccult test, the detection rate of polypoid lesions was 41.9% with use of an immunological method, whereas it was 19.7% with use of a chemical method. In conclusion, (1) detection of colonic polypoid lesions can lead to the detection of early cancer, although only histological examination can confirm the accurate diagnosis ; (2) a hemoccult test in stool with an immunological method is an effective method for screening asymptomatic colonic polypoid lesions, although it must be admitted that negative results may occasionally occur ; (3) macroscopic observation of the stool mass is important before sampling, because lesions of the sigmoid colon or the rectum may show scanty blood only on the limited area of the surface of the stool ; (4) patients elder than 50 years of age should be examined more carefully for the whole colon preferably with an endoscope, because they show a high incidence of small polypoid lesions in the right hemicolon. kn-abstract=1986年4月から1990年2月末までの間に岡山大学医学部附属病院三朝分院で経験した早期大腸癌を含む大腸ポリープ90例（107病変）を対象に，年齢，臨床症状，便潜血反応，病変存在部位について検討を行い，以下の成績を得た。(1)大腸検査総数の22.4％にポリープが発見された。ポリープの77％は腺腫，5％は腺癌（早期癌）であった。(2)便潜血反応はポリープ例の75.9％に陽性であり，右側大腸ポリープでの陽性率は高かったが，S状結腸および直腸ポリープでは70％程度であった。(3)若年者では右側結腸にポリープが発見されることは稀であるが，50才以上では18％程度に認められた。高齢者では右側結腸も内視鏡で検査することが重要である。(4)免疫学的便潜血検査法の導入により大腸ポリープの発見効率が改善するものと考え られた。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=TachibanaHideo en-aut-sei=Tachibana en-aut-mei=Hideo kn-aut-name=立花英夫 kn-aut-sei=立花 kn-aut-mei=英夫 aut-affil-num=6 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=7 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学附属病院三朝分院放射線科 affil-num=8 en-affil= kn-affil=岡山大学附属病院三朝分院放射線科 en-keyword=大腸ポリープ (Polyp of the colon) kn-keyword=大腸ポリープ (Polyp of the colon) en-keyword=大腸早期癌 (Early cancer of the colon) kn-keyword=大腸早期癌 (Early cancer of the colon) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=79 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diabetic complications in the advanced stage of chronic pancreatitis. kn-title=膵性糖尿病の合併症 en-subtitle= kn-subtitle= en-abstract=Exocrine dysfunction (maldigestion) and endocrine dysfunction (diabetes) are malll clinical features in the advanced stage of chronic pancreatitis. Diabetic complications were previously considered to be infrequent in diabetes secondary to chronic pancreatitis (pancreatic diabetes). However, the recent improvement in life expectancy and closer observation of the clinical course of patients with chronic pancreatitis have revealed that diabetic complications are not infrequent in pancreatic diabetes as compared with primary diabetes mellitus and that diabetes is one of the most important prognostic factors in chronic pancreatitis. We, therefore, reviewed recent articles on the topics before beginning a national survey of diabetic complications in patients with pancreatic diabetes. It has been suggested that : (1) diabetic microangiopathy (retinopathy, nephropathy and peripheral neuropathy) is almost as frequent in secondary diabetes as in primary diabetes, although the severity is less in secodary diabetes : (2) peripheral neuropathy is frequent in alcoholic chronic pancreatitis : (3)macroangiopathy (myocardial infarction, cerebral thrombosis, atherosclerosis) is less frequent in pancreatic diabetes. We also discussed various factors which may precipitate the diabetic complications. kn-abstract=慢性膵炎が進行すると膵内外分泌不全に対する治療が主体となる。かつては膵疾患に由来する糖尿病（膵性糖尿病）においては糖尿病性合併症の発症が少ないとされていたが，慢性膵炎の長期経過観察例の増加とともにその頻度が一次性糖尿病にくらべて必ずしも低くないことが指摘されるようになった。そこで今回，厚生省難治性膵疾患調査研究班「慢性膵炎の新しい治療法の開発」小委員会の研究活動の一環として膵性糖尿病の治療法を再検討することになったのを機会に，その手始めに野性糖尿病の合併症に関する従来の報告を整理した。その結果，一次性糖尿病の場合にくらべて，細小血管症（網膜症，腎症，神経障害）はほぼ同程度であるが軽症例が多いこと，大血管症（心筋梗塞，脳硬塞，動脈硬化症）は少ないことが示唆された。そのほか，膵性糖尿病の合併症の発症に関与すると考えられる諸因子についても概説した。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=TachibanaHideo en-aut-sei=Tachibana en-aut-mei=Hideo kn-aut-name=立花英夫 kn-aut-sei=立花 kn-aut-mei=英夫 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=膵性糖尿病 (Pancreatic diabetes) kn-keyword=膵性糖尿病 (Pancreatic diabetes) en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=合併症 (Complications) kn-keyword=合併症 (Complications) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=46 end-page=54 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Thermological study on the coldness in women kn-title=サーモグラフィによる冷え症の病態生理学的検討 en-subtitle= kn-subtitle= en-abstract=Whole body surface temparature was measured in 41 women with a thermtracer 6T66. Except palm, sole and instep, there were no differences in surface temperature of other parts of the body among these cases. Surface temperature of palm, sole and instep were lower than other parts of the body and showed 4 characteristic distribution patterns on thermography. Thermography at palm, sole and instep is useful for the objective approach of the patients who complain of coldness in some part of their bodies. kn-abstract=サーモグラフィを用いた冷え症の診断基準を作ることを目的として，冷え症患者（30名）の体表面温度分布を体表面を11カ所に分けて中間温環境下でサーモトレーサ6T66を1用いて測定し，対称群（11名）と比較した。同時にCMI調査と，患者の日常生活に関するアンケート調査を実施した。その結果1．冷え症群では四肢末端部，ことに手掌・足背・足底において最低温度が低く，局所の最高・最低温度間の温度較差が大きい傾向を示した。?幹部では最高温度，最低温度，温度較差すべて両群間に大きな差はみられなかった。2．冷え症群の手掌，足背，足底の温度分布パターンは末端部ほど温度が低いという特徴的なパターンを多く示した。3．CMI調査では，冷え症群の中等症と軽症例の一部に強い神経症的傾向を認めたが，重症例では神経症的傾向は軽度であった。4．アンケート調査では脂っこいものよりあっさりしたものを好きであるとか，顔にのぼせを感じることがある，甘いものが好きであるという例が冷え症群に多かった。以上の結果からサーモグラフィを用いて中間温環境下で四肢末端の温度鈴布を測定することにより，冷え症を客観的に診断する可能性を得た。 en-copyright= kn-copyright= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=1 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=2 ORCID= en-aut-name=SekibaKaoru en-aut-sei=Sekiba en-aut-mei=Kaoru kn-aut-name=関場香 kn-aut-sei=関場 kn-aut-mei=香 aut-affil-num=3 ORCID= en-aut-name=TanizakiYosiro en-aut-sei=Tanizaki en-aut-mei=Yosiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=婦人の冷え症 (Coidness in women) kn-keyword=婦人の冷え症 (Coidness in women) en-keyword=サーモグラフィ (Thermography) kn-keyword=サーモグラフィ (Thermography) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=55 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Antithrombogenic therapy after heart valve replacement - Effect of anti-platelet drug on aggregation- kn-title=人工弁置換後の抗凝血療法 ―血小板凝集抑制剤の効果― en-subtitle= kn-subtitle= en-abstract=To evaluate the effect of anti-thrombotic thrapy after valve replacement, serial platelet aggregation measurememnts were carried out in 103 patients. Patients were divided into three groups. e. i. warfarin alone (control), warfarin with trapidil (TP) of 300mg/day and dipyridamole (DP) of 300mg/day. The aggregation of platelet of the control group did not change through 36 months. TP group showed a decrease in platelet aggregation at 24 and 30 months from the pretreatment value. The aggregation of 24 month in TP was significantly lower than that of control. There was no difference of platelet aggregation between TP and DP group. The incidence of thromboembolism of control, TP and DP group were 9.5%, 4.3% and 7.7%, respectively. These data suggest that the supression of platelet aggregation .by TP and DP is not adequate to continue for long time and TP has similar anti-thrombotic effect to DP. kn-abstract=人工弁置換患者の血栓塞栓症（TE）は，長期予後の成績を左右する。　TEを減少させるために凝固因子を抑制するwarfarinと抗血小板剤による抗血栓療法が行われている。人工弁置換患者103例を対象に，抗血小板剤であるtrapidil（TP）とdipyridamole（DP）の血小板凝集能に与える効果を検討した。36ヵ月間検討したが，warfarin単独群は血小板凝集能に変化がなく，TP，DP共にADP凝集能を抑制した。しかし有意差の見られたのは全経過ではなく，凝集能抑制は強力かつ持続的ではなかった。またコラーゲン誘導凝集能は変化を認めなかった。TPとDPの抗血小板効果は同等と思われる。期間中の血栓塞栓発生は，warfarin単独群9.5％，TP群4.3％，DP群7.7％であった。臨床的に抗血小板剤の併用は有効と思われるが，血小板凝集抑制には投与量の増量，あるいは他の薬剤の検討が必要であろう。 en-copyright= kn-copyright= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=1 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=2 ORCID= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=3 ORCID= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末真八 kn-aut-sei=森末 kn-aut-mei=真八 aut-affil-num=4 ORCID= en-aut-name=HiraiShunnichi en-aut-sei=Hirai en-aut-mei=Shunnichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=5 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=6 ORCID= en-aut-name=KajitaniNobuaki en-aut-sei=Kajitani en-aut-mei=Nobuaki kn-aut-name=梶谷伸顕 kn-aut-sei=梶谷 kn-aut-mei=伸顕 aut-affil-num=7 ORCID= en-aut-name=YoshizaneKen en-aut-sei=Yoshizane en-aut-mei=Ken kn-aut-name=吉實憲 kn-aut-sei=吉實 kn-aut-mei=憲 aut-affil-num=8 ORCID= en-aut-name=NaniwaHiroyuki en-aut-sei=Naniwa en-aut-mei=Hiroyuki kn-aut-name=浪花宏幸 kn-aut-sei=浪花 kn-aut-mei=宏幸 aut-affil-num=9 ORCID= en-aut-name=KojoMasayoshi en-aut-sei=Kojo en-aut-mei=Masayoshi kn-aut-name=古城昌義 kn-aut-sei=古城 kn-aut-mei=昌義 aut-affil-num=10 ORCID= en-aut-name=TeramotoShigeru en-aut-sei=Teramoto en-aut-mei=Shigeru kn-aut-name=寺本滋 kn-aut-sei=寺本 kn-aut-mei=滋 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院第二外科 en-keyword=人工弁置換術 (Heart valve replacement) kn-keyword=人工弁置換術 (Heart valve replacement) en-keyword=血栓塞栓症 (Thromboembolism) kn-keyword=血栓塞栓症 (Thromboembolism) en-keyword=血小板凝集 (Platelet aggregation) kn-keyword=血小板凝集 (Platelet aggregation) en-keyword=抗血小板剤 (Anti-thrombotic drug) kn-keyword=抗血小板剤 (Anti-thrombotic drug) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=114 end-page=122 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hyhrid vascular grafts and one of our approaches kn-title=人工血管のハイブリット化 en-subtitle= kn-subtitle= en-abstract=Recently, vascular grafts had contributed in the treatments of various vascular disease, and today, was required to have fine functions like native blood vessels. Many kinds of approaches to develop the ideal graft had been applied. In these efforts, endothelial cells seeding technique to fabric vascular prostheses was reported successfully, however, it was not for general use. To get and proliferate the endothelial cells, special techniques and facilities were required. Moreover, it was not available for emergency use, smce the cell culture needed a certain period of time. To overcome these problems, we developed a reliable method to make a hybrid vascular graft as follows. Tissue fragments suspension was prepared using a piece of peripheral vein. Highly porous fabric vascular prosthesis was immersed into the suspension fluid. The tissue fragments were trapped from the outer surface of the prosthesis by intraluminal suction. Preclotting procedure was adopted to immobilize the tissue fragments to the fabric of the prosthesis. The prostheses were implanted into the thoracic descending aortae of 15 dogs. There was no bleeding at the time of the implantation. Numerous endothelial cells proliferation was observed in the specimen for 5 days after implantation. The surface was covered with thin layer of fibrin. Full endothelialization was noticed in the specimens of 35 days. The graft wall was completely healed. This method was very simple and easy to prepare, but the efficacy to promote the healing of the neointima was excellent. kn-abstract=人工血管により高度な機能をもたす目的で，ハイブリット化が今日進められるようになってきた。この背景について説明するとともに，我々の独自に行っているハイブリット型人工血管作成の方法およびその成果について報告する。その具体的方法としては以下の通りである。末梢静脈小片を勇刀にて細切したのち，約20ccの生理的食塩水に入れて静脈組織細切片浮遊液を作った。次に高有孔性人工血管の一端より吸引管を挿入し，これを作成した液に入れ，吸引によって組織片を外側から人工血管壁に絡ませた。次に新鮮な血液を注ぎ，組織片をさらに固着させた。成犬胸部下行大動脈へこのような処理をしたポリエステル布製人工血管を植え込んだところ，植え込み5日目に新生血管壁内部に無数の内皮細胞の増殖像がみられ，35日目の例では吻合部はもとより，人工血管の中央部ですら内皮細胞による完全な被覆を認めた。 　以上のような方法で新生血管壁が容易に形成されることが判明したことより，今後，他の人工臓器分野でもハイブリット化が予測される。 en-copyright= kn-copyright= en-aut-name=NoishikiYasuharu en-aut-sei=Noishiki en-aut-mei=Yasuharu kn-aut-name=野一色泰晴 kn-aut-sei=野一色 kn-aut-mei=泰晴 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 en-keyword=人工血管 (Vascular graft) kn-keyword=人工血管 (Vascular graft) en-keyword=ハイブリット (Hybrid) kn-keyword=ハイブリット (Hybrid) en-keyword=新生内膜 (Neointima) kn-keyword=新生内膜 (Neointima) en-keyword=内皮細胞 (Endothelial cell) kn-keyword=内皮細胞 (Endothelial cell) en-keyword=自家移植 (Autologous transplantation) kn-keyword=自家移植 (Autologous transplantation) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=89 end-page=97 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical significance of eosinophilic leucocytes in onset mechanisms of bronchial asthma kn-title=気管支喘息の発症病態における好酸球の臨床的意義 en-subtitle= kn-subtitle= en-abstract=Participation of eosinophil leucocytes in onset mechanisms of bronchial asthma was discussed in following sections ; 1. changes in number of eosinophils in the peripheral blood, 2. emergence of eosinophils in local allergic reaction sites, 3. eosinophils and allergic reactions, 4. different functions of eosinophils III allergic reactions, 5. eosinophils and clinical types of bronchial asthma. The results showed that eosinophilia in the peripheral blood was generally observed in patients with bronchial asthma. In these cases, eosinophils migrated into local allergic reaction sites. A reversed correlation was present between number of eosinophils and macrophages, and number of eosinophils correlated to a certain extent with number of lymphocytes in the small airways and alveolar region. Function of eosinophils was shown to be different between IgE-and non-IgE-mediated reactions, by measurement of arylsulfatase activity III BALF. Marked eosinophilia in BALF was observed in any clinical types of atopic asthma, although eosinophils were increased only in bronchoconstriction + hypersecretion type (type II) of non-atopic asthma. kn-abstract=末梢血好酸球が気管支喘息の発症病態にどのように関与しているかについて，1．末梢血好酸球の変動，2．好酸球の局所出現，3，好酸球とアレルギー反応，4．アレルギー反応と好酸球の機能，5．好酸球と喘息の臨床病態の各項目で検討した。その結果，気管支喘息では，全般的に末梢血好酸球増多がみられ，同時にアレルギー反応局所への遊走が観察されること，末梢気 道では，ある程度肺胞マクロファージの出現と逆相関にあること，リンパ球との関連もある程度認められることなどが示された。そして，局所出現した好酸球は，IgE抗体の関与の程度により，その機能が異なる可能性が示唆された。また臨床病型別の検討では，アトピー型ではいずれの臨床山型においても好酸球の出現率は明かな増加傾向を示したが，非アトピー型では，Ib．気管支攣縮＋過分二型においてのみ好酸球増多が著明であった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=6 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=好酸球 (Eosinophils) kn-keyword=好酸球 (Eosinophils) en-keyword=肺生検 (Lung biopsy) kn-keyword=肺生検 (Lung biopsy) en-keyword=気管支肺胞洗浄 (Bronchoalveolar lavage) kn-keyword=気管支肺胞洗浄 (Bronchoalveolar lavage) en-keyword=臨床病型 (Clinical type) kn-keyword=臨床病型 (Clinical type) en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=98 end-page=113 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=New trend of the development of vascular prostheses kn-title=人工血管開発における研究の動向 en-subtitle= kn-subtitle= en-abstract=Vascular prostheses have been used in the treatments of various vascular diseases. We expect much from their contribution in the field of further fine vascular surgery. In this communication, new trend of the development of them with our new ideas in our recent research works were described. 1. Healing process of fabric vascular prostheses. Neointima formation of the vascular prosthesis implanted in the descending thoracic aortae of experimental animals were described in detail. This showed a standard behaviour of various cells which contributed the construction of a new arterial wall. 2. Problems of vascular prostheses which were used in clinic. Several problems such as a bleeding from the graft wall, aneurysmal dilatation, and degenerative changes of the neointimae were explained in detail. These problems were related with the structure of each vascular prosthesis. 3. Vascular prostheses developing with new ideas. Several vascular prostheses developing today were described as follows. (a) Fabric prosthesis with high healing ability. A prosthesis made of ultra-fine polyester fibers which can accerelate cell migration and proliferation inside the prosthetic wall was introduced. The neointima in this prosthesis was constructed very rapidly compared with that of the prostheses made of polyester fiber ordinally used. (b) Antithrombogenic small diameter vascular prostheses. Large caliber vascular prostheses have been used very safely in clinic, however, small diameter ones were seldom used due to its low patency rate by their occlusion. The grafts should have an antithrombogenic property to prevent the thrombus formation. Recently, some technologies to give antithrombogenic property to the vascular prostheses were developed. They were a heparin slow release technique, antithrombogenic segmented polyurethane, highly hydrous surface, heparinized collagen tube, etc. They were applied for the development of small diameter vascular grafts and showed good results in some animal experiments. (c) Growable vascular graft. A vascular graft which can grow with the growth of its recipient baby was demonstrated. The animal study showed as expected growth and stop growing at the expected time. (d) Vascular graft for aorto-coronary bypass surgery. A small diameter antithrombogenic, and flexible vascular grafts were explained. They were developed along our own ideas. This showed high patency rate m animal experiments. (e)Endothelial cell seeding techniques. In human, endothelialization m the vascular grafts is delayed and the inner surface was thrombogenic for a long period of time. To accerelate the endothelialization, cell seeding technique have been investigated in the last decade. We developed a new technology to transplant autologous cells in the peripheral vein tissue for this purpose. This was very reliable and simple. It was applicable in any hospital without any special technique and facility. Peripheral venous tissue fragments were transplanted into the fabric vascular prosthetic wall. Endothelial cells and smooth muscle cells migrated and proliferated from the tissue fragments. The neointima was constructed very rapidly with this active cell migrations. kn-abstract=人工血管の開発研究における動向について，我々の行ってきた研究をまじえて世界の動きを解析した。近年の砺究の流れは過去1世紀にわたる試行錯誤の上にあって，さらに大きく揺れ動いている。人工血管の内面に必要な抗血栓性の獲得においても，設計者によって考えを異にし，米国では，人工心臓に用いる抗血栓性合性高分子材料をもってそれに当てようとしているものが多い。我々はあくまで宿主のもつ諸機能を引き出し，自然の動きの一つとしての治癒を無理なく導いて，内皮細胞によって内面を覆わせる方法を採用している。そのいくつかの例として，超極細ポリエステル繊維製人工血管，結合組織管，バイオマトリックス人工血管，ヘパリン化生体組織由来人工血管，成長できる人工血管などについて解説した。 en-copyright= kn-copyright= en-aut-name=NoishikiYasuharu en-aut-sei=Noishiki en-aut-mei=Yasuharu kn-aut-name=野一色泰晴 kn-aut-sei=野一色 kn-aut-mei=泰晴 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 en-keyword=人工血管 (Vascular prosthesis) kn-keyword=人工血管 (Vascular prosthesis) en-keyword=新生内膜 (Neointima) kn-keyword=新生内膜 (Neointima) en-keyword=内皮細胞 (Endothelial cells) kn-keyword=内皮細胞 (Endothelial cells) en-keyword=抗血栓性 (Antithrombogenicity) kn-keyword=抗血栓性 (Antithrombogenicity) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=68 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本に於ける二酸化炭素泉療法の現況 kn-title=CO(2) Balneotherapy in Japan en-subtitle= kn-subtitle= en-abstract=日本では，天然の二酸化炭素泉は殆ど利用されていない。一方，CO(2)錠剤，CO(2)給水装置が開発されて人工二酸化炭素泉がよく用いられるようになってきた。皮下組織の酸素分圧の上昇と組織循環の改善という好ましい生理作用により，結合織の退行性変化による慢性障害，すなわち強皮症，関節症，慢性関節痛，腰痛症，および末梢循環障害に伴う組織の栄養障害に適応がある。また，疲労回復を促進し，いわゆる冷え症に好ましく作用する。 kn-abstract=Natural CO(2) springs have been scarcely utilized in Japan, whereas artificial CO(2) bathing has become popular by the introduction of CO(2) tablets and other apparatus for CO(2) water supply. Artificial CO(2) bathing is indicated for degenerative connective tissue disorders such as scleroderma, common stiff and painful shoulders, chronic joint pain, lumbago, and trophic changes due to insufficient peripheral circulation by virtue of the increase of tissue pO(2) and the improvement of tissue perfusion. Artificial CO(2) bathing promotes recovery from fatigue and is beneficial in women whose health has been adversely affected by cold. en-copyright= kn-copyright= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=1 ORCID= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=2 ORCID= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=3 ORCID= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末真八 kn-aut-sei=森末 kn-aut-mei=真八 aut-affil-num=4 ORCID= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=5 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 en-keyword=CO(2) -balneotherapy kn-keyword=CO(2) -balneotherapy en-keyword=Artificial CO(2) -bathing kn-keyword=Artificial CO(2) -bathing en-keyword=Tissue pO(2) kn-keyword=Tissue pO(2) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=61 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical evaluation of new formula included oligopetide as a nitrogen source in surgical patients kn-title=オリゴペプチド経腸栄養剤の使用経験 en-subtitle= kn-subtitle= en-abstract=The clinical usefulness of new enteral formula which is contained di-and tri-peptides as a nitrogen source was evaluated in surgical patients. The enteral nutrition was introduced to stable patients who could not take food orally and postoperative ones who were undertaken upper GI surgery. Adverse effects such as diarrhea or abdomonal distension were not observed. V isceral proteins were improved after administration of this regimen and nutritional status was maintained in all patients. However, high urinary excretion of 3methylhistidine continued in great extent during postopertive period and breakdown of skeletal muscle was not prevented by this nutritional therapy. This might be due to insufficient intake of energy and nitrogen. This new product for enteral nutrition would be safe and useful as enteral nutrition. kn-abstract=窒素源としてdi-，tri−peptideを含有した経腸栄養剤を外科患者に使用した。．この新しい経腸栄養剤は卵白を加水分解したもので，70％がoligopeptideであり，アミノ酸も10％含まれる。糖質はデキストリンで，脂肪の含有量は少なく浸透圧はエレメンタルダイエット（ED）より低い。この製剤を安定期および術後に使用した。アルブミン，rapid turnover proteinの回復がみられ，臓器蛋白の合成が得られた。術後例では3メチルヒスチジンの排泄量は減少せず，異化反応は抑制されなかった。投与量の不足が一つの原因と思われる。副作用の下痢はほとんどみられず，栄養改善効果もあり，有用性が認められた。 en-copyright= kn-copyright= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=1 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=2 ORCID= en-aut-name=MorisueSinhachi en-aut-sei=Morisue en-aut-mei=Sinhachi kn-aut-name=森末真八 kn-aut-sei=森末 kn-aut-mei=真八 aut-affil-num=3 ORCID= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=4 ORCID= en-aut-name=Suzukalchio en-aut-sei=Suzuka en-aut-mei=lchio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=5 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=6 ORCID= en-aut-name=KajitaniNobuaki en-aut-sei=Kajitani en-aut-mei=Nobuaki kn-aut-name=梶谷伸顕 kn-aut-sei=梶谷 kn-aut-mei=伸顕 aut-affil-num=7 ORCID= en-aut-name=YoshizaneKen en-aut-sei=Yoshizane en-aut-mei=Ken kn-aut-name=吉實憲 kn-aut-sei=吉實 kn-aut-mei=憲 aut-affil-num=8 ORCID= en-aut-name=NaniwaHiroyuki en-aut-sei=Naniwa en-aut-mei=Hiroyuki kn-aut-name=浪花宏幸 kn-aut-sei=浪花 kn-aut-mei=宏幸 aut-affil-num=9 ORCID= en-aut-name=TeramotoShigeru en-aut-sei=Teramoto en-aut-mei=Shigeru kn-aut-name=寺本滋 kn-aut-sei=寺本 kn-aut-mei=滋 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院第二外科 en-keyword=経腸栄養 (Enteral nutrition) kn-keyword=経腸栄養 (Enteral nutrition) en-keyword=エレメンタルダイエット (Elemental diet) kn-keyword=エレメンタルダイエット (Elemental diet) en-keyword=オリゴペプチド (Oligopeptide) kn-keyword=オリゴペプチド (Oligopeptide) en-keyword=外科栄養 (Surgical nutrition) kn-keyword=外科栄養 (Surgical nutrition) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=168 end-page=183 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Publications and lectures in 1989 kn-title=業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=143 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Acivities of the nursing division 1989 kn-title=看護部活動報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三朝分院看護部 kn-aut-sei=三朝分院看護部 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=123 end-page=128 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of stepping measurement device for evaluation of and training in walking kn-title=群性膵炎の発症原因の検索中に発見された小膵癌の検討 en-subtitle= kn-subtitle= en-abstract=Although gait training equipment such as the bicycle ergometer and treadmill exists for patients whose walking ability is high, there is no appropriate gait training mehtod or training instrument for patients whose walking ability has become impaired, who often use a cane or walker, etc. in the course of daily life. In the case of gait training for persons whose walking ability involves impaired locomotion, there is always the danger of a fall. Consequently, a caregiver is required, and the effect of the training is cut by half because the patient's anxiety about falling is exacerbated. Slow stepping affords strengthening and balance training of the leg muscles for patients whose walking ability has become low, and walking ability is improved. However,whether such training appropriately carries out stepping and the degree of the effect of such training has not been evaluated. Therefore, we have developed a stepping measturement device that monitors stepping for evaluation and training of walking ability. This system consists of two mat switches for stepping, a measuring circuit for stepping detection, and a book-sized personal computer with a PC card-type AD converter. This system can detect a left or right single stance phase and a double stance phase relative to the ON, OFF condition of the mat switch. After measurement, the following items are analyzed and displayed : ・number of steps, ・average time of double stance phase, ・the average time of single stance phase, and so on. Finally, we measured the stepping of subjects whose walking ability is low, and showed the relationship between daily walking conditions and stepping conditions. The effectiveness of this system was considered in light of the results. kn-abstract=急性膵炎の回復後その発症原因の検索において発見された小膵癌の3例を報告し，膵炎の発症原因の一つとして膵癌を常に念頭におく必要があることを強調した。またスクリーニング検査および精査において小膵癌を診断する手順について考察を加えた。症例1は初回発作の回復後に，症例2および症例3は再発発作の回復後に急性膵炎の発症原因の検索を目的に紹介された。いずれの症例においても血清腫瘍マーカーは正常植を示し，腹部USおよびCTは腫瘍から尾側の膵管の拡張を示したが腫瘍そのものは描出はできなかった。症例1ではERCP像から膵体部癌を強く疑い，症例2と症例3ではERCP像と細胞診陽性所見から膵頭部癌と確診し，手術を行った。腫瘍の最大径は症例1では0.9cm，症例2では1.5cm，症例3では2.0cmであり，いずれも転移を認めず根治切除可能であった。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=3 ORCID= en-aut-name=TachibanaHideo en-aut-sei=Tachibana en-aut-mei=Hideo kn-aut-name=立花英夫 kn-aut-sei=立花 kn-aut-mei=英夫 aut-affil-num=4 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=TsuboiKeiichi en-aut-sei=Tsuboi en-aut-mei=Keiichi kn-aut-name=壷井圭一 kn-aut-sei=壷井 kn-aut-mei=圭一 aut-affil-num=7 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=小膵癌 (Small pancreatic cancer) kn-keyword=小膵癌 (Small pancreatic cancer) en-keyword=膵癌の早期発見 (Early diagnosis of pancreatic cancer) kn-keyword=膵癌の早期発見 (Early diagnosis of pancreatic cancer) en-keyword=急性膵炎 (Acute pancreatitis) kn-keyword=急性膵炎 (Acute pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=134 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of malignant lymphoma of the small intestine kn-title=原発性小腸悪性リンパ腫の一例 en-subtitle= kn-subtitle= en-abstract=A 60 - year-old man complaining of right lower abdominal pain was sent to the operating room for acute appendicitis. The ileocoecal resection was performed for ulceration of the terminal ileum, which was diagnosed as an intestinal malignant lymphoma histologically. The case, therefore, was re-operated three weeks after the first operation. The right half of colon, and about 70 centimeters of ileum with their regional lymphnodes were resected. The case was revealed as the first stage of clinical classification by Naqvi et al. Up to the present time, 7 months after the first operation, there were no sIgns of reccurence. Intestinal malignant lymphoma somtimes has need to do an emergency oparation, and reoperation should be done without hesitation, if necessary. kn-abstract=原発性小腸悪性リンパ腫は，術前診断が困難で予後が悪い，比較的希な疾患である。我我の症例は60歳の男性で，右下腹部痛にて来院し，急性虫垂炎の診断で手術を施行した。手術時，回腸末端部より10cm口側に潰瘍性病変を認め，クローン病を疑って回盲部切除を施行した。病理組織検査にて悪性リンパ腫，difuse，medium sized cell typeと診断され，広範回腸切除を含む右記結腸切除及び所属リンパ節郭清を行った。リンパ節転移は認めず，stage I，治癒切除と考えられた。術後7カ月現在，再発の徴候無く外来通院中である。本症は5年生存率22〜40％と茅後の悪い疾患であるが，stage I・IIとstage III・IV，治癒切除と非治癒切除の生存率には明かな差があり，早期の診断と根治切除の重要性を示唆している。また本症は，緊急手術を要する場合や自験例のごとく急性虫垂炎の診断で手術を受けることが少なからずあると思われ，根治切除に確信のもてない場合は再手術をためらってはならないと考える。 en-copyright= kn-copyright= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=1 ORCID= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=2 ORCID= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末慎八 kn-aut-sei=森末 kn-aut-mei=慎八 aut-affil-num=3 ORCID= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=4 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=5 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 en-keyword=小腸悪性リンパ腫 (Malignant lymphoma of the small intestine) kn-keyword=小腸悪性リンパ腫 (Malignant lymphoma of the small intestine) en-keyword=小腸悪性腫瘍 (Malignant tumor of the small intestine) kn-keyword=小腸悪性腫瘍 (Malignant tumor of the small intestine) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=147 end-page=167 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On climatology in Misasa spa (twelfth report） kn-title=三朝温泉地の気候について（第12報） en-subtitle= kn-subtitle= en-abstract=Climatological data of the last 12 months (1988.1.1−1988.12.31） obtained by the climate　autorecording　system at the Misasa Medical Branch in Misasa spa, Tottori−Ken, Japan, are presented. kn-abstract=われわれは1956年以降，三朝温泉地の気候要素について観測を行ってきているが，今回は第12報として，ひきつづき1988年1月1日から1988年12月末日までの1ヵ年の気象観測の資料を報告することとした。なお1985年4月1日以降は自動記録装置が備えられたので，今回の資料はすべてこの自動記録装置によるものである。 en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=EndouHiroi en-aut-sei=Endou en-aut-mei=Hiroi kn-aut-name=遠藤裕井 kn-aut-sei=遠藤 kn-aut-mei=裕井 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=129 end-page=133 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of atopic asthma characterized by marked neutrophilia in BALF kn-title=気管支肺胞洗浄液（BALF）中に高度の好中球増多の見られたアトピー型喘息の一例 en-subtitle= kn-subtitle= en-abstract=The clinical course and characteristics of a case with atopic asthma, showing marked neutrophilia in BALF and severe asthma attacks, were observed the frequency of neutrophils in BALF decreased followed by the improvement of her asthma attacks with therapy. The frequency of neutrophils in BALF was 65.4% at the initial stage before the therapy and decreased to 5.6% at attackfree stage after the therapy. The changes in frequency of neutrophils in BALF, obserbed in this case, should be noticed, because the cell in BALF were hardly affected by any treatment. kn-abstract=気管支肺胞洗浄液（BALF）中に高度の好中球の増多が見られ，治療により臨床症状の軽快と共にBALF中の好中球の減少を認めたアトピー型喘息の一例を経験した。経過中5回施行したBALF中の好中球百分率はそれぞれ65.4％，56.2％，42.4％，5.6％，5.6％であり，4回目，5回目では著明な好中球減少を認めた。本症例の如き症例は今後増加することが予想され，その発症病態を含め今後さらに症例を重ねて検討して行く必要があると 考えられた。 en-copyright= kn-copyright= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshirou en-aut-sei=Tanizaki en-aut-mei=Yoshirou kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= en-aut-name=KataokaHisakazu en-aut-sei=Kataoka en-aut-mei=Hisakazu kn-aut-name=片岡久和 kn-aut-sei=片岡 kn-aut-mei=久和 aut-affil-num=6 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=7 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=アトピー型喘息 (Atopic asthma) kn-keyword=アトピー型喘息 (Atopic asthma) en-keyword=好中球 (Neutrophil) kn-keyword=好中球 (Neutrophil) en-keyword=気管支肺胞洗浄法 (Bronchoaiveolar lavage) kn-keyword=気管支肺胞洗浄法 (Bronchoaiveolar lavage) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=138 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case report of appendiceal calculus presented as abdominal tumor kn-title=腹部腫瘤を主訴とした虫垂結石の一例 en-subtitle= kn-subtitle= en-abstract=Appendiceal calculi are found in the only several percent of patients with appendicitis and have been known to be complicated in severe appendicitis or perforated peritonitis. We reported a 41-year-old female patient, whose initial symptom was right lower abdominal tumor of insidious growing. Abdominal examination revealed a small fist sized hard mass in the right lower abdomen with slight tenderness, and free of rebound tenderness and muscle defence. Abdominal ultrasonography and computed tomography showed that the tumor had continuity with appendix and contained calcification inside. Accordingly, she was diagnosed to have an appendiceal neoplasm and operated on. Post-operative diagnosis was appendiceal abscess with a calculus, 1 centimeter in diameter. It is rare that appendiceal calculi manifest a palpable abdominal tumor like this case. kn-abstract=虫垂結石は虫垂炎手術例の数％に見られるに過ぎないが，穿孔性腹膜炎などの重篤な炎症を招く可能性が高いことで知られている。自験例は41才の女性で，右下腹部腫瘤を主訴として来院した。画像診断で腫瘤は虫垂に連続し，内部に石灰化を認めたが，腫瘤が硬く，虫垂炎症状が軽微であったことから，虫垂原発腫瘍を疑い手術を行ったところ，虫垂膿瘍を併発した虫垂結石であった。本症が自験例のように触知可能な腹部腫瘤を形成することは比較的まれである。 en-copyright= kn-copyright= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=1 ORCID= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=2 ORCID= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末真八 kn-aut-sei=森末 kn-aut-mei=真八 aut-affil-num=3 ORCID= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=4 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=5 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 en-keyword=虫垂結石 (Appendiceal calculus) kn-keyword=虫垂結石 (Appendiceal calculus) en-keyword=腹部腫瘤 (Abdominal tumor) kn-keyword=腹部腫瘤 (Abdominal tumor) en-keyword=急性虫垂炎 (Acute appendicitis) kn-keyword=急性虫垂炎 (Acute appendicitis) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=7 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for chronic respiratory diseases - in subjects admitted in 1989. - kn-title=慢性呼吸器疾患の温泉療法 en-subtitle= kn-subtitle= en-abstract=Backgrounds and immunological characteristics were studied in patients with chronic respiratory diseases admitted at Misasa Branch Hospital in 1989. At the same time, clinical effects of spa therapy were evaluated for these patients. 1. Eighty five patients with chronic respratory diseases comprised 65 patients with bronchial asthma, 4 with pulmonary emphysema, 4 with lung tuberculosis, 3 with allergic granulomatous angitis, 3 with obstructive bronchiolitis, 2 with bronchiectasia, 2 with chronic bronchitis and 2 with hypersensitivity pneumonitis. 2. Sixty three patients (74.1%) out of the 85 cases had spa therapy. 3. Out of 51 patients coming from Tottori prefecture, 32 cases (62.7%) received spa therapy. On the other hand, spa therapy was carried out for 19 cases (95.0%) out of the 20 cases from Okayama prefecture, and for 12 cases (85.7%) out of the 14 cases from the other prefectures (long distant areas). 4. Many cases with bronchial asthma showed low serum levels of IgE (lower than 200 IU/ml), and frequency of positive skin reactions to various allergens was low in the patients with bronchial asthma. Serum cortisol levels were very low in patients with steroid-dependent asthma. 5. Spa therapy was effective in 41 cases (80.3%) out of the 51 patients with bronchial asthma. Spa therapy also effective for patients with obstructive bronchiolitis, and allergic granulomatous angitis. kn-abstract=1989年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者85例（延べ90例）を対象に，その背景因子，臨床的特徴，および温泉療法の臨床効果について検討を加えた。(1)対象85例のうちわけは，気管支喘息65例，肺気腫4例，肺結核症4例，アレルギー性肉芽腫性血管炎3例，閉塞性細気管支炎3例，気管支拡張症2例，慢性気管支炎2例，過敏性肺臓炎2例であり，昨年度と異なり肺結核がやや多かったことが特徴的であった。(2)これら85症例のうち，温泉療法を受けた症例は63例(74.1％)であった。(3)温泉療 法を受けた症例の地域分布では，鳥取県からの入院症例51例では32例(62.7％)であり，同様に岡山県からの入院症例20例では19例(95.0％)，その他の県からの入院症例14例で12例(85.7％)であった。4．温泉療法の臨床効果は，気管支喘息では51例中著効14例，有効27例，やや有効8例，無効2例であり，明らかな有効例は41例（80.3％)であった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=6 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=閉塞性細気管支炎 (Obstructive bronchiolitis) kn-keyword=閉塞性細気管支炎 (Obstructive bronchiolitis) en-keyword=慢性気管支炎 (Chronic bronchitis) kn-keyword=慢性気管支炎 (Chronic bronchitis) en-keyword=血清コーチゾール値 (Serum cortisol level) kn-keyword=血清コーチゾール値 (Serum cortisol level) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=16 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者末梢血好塩基球の抗ヒトIgEおよびカルシウムイオノフォァA23187に対する反応性について kn-title=Basophil reactivity to anti-IgE and calcium ionophore A23187 in patients with bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息27例および健康人7名を対象に，抗ヒトIgEおよびカルシウムイオノフォァA23187（CaI)刺激時の末梢血好塩基球からのヒスタミン遊離について検討を加えた。(1)抗ヒトIgEおよびCaI刺激時の好塩基球からのヒスタミン遊離は，非アトピー型喘息に比べ，アトピー型喘息において有意に高い値を示した。(2)これらの刺激物質によるヒスタミン遊離は，非使用例に比べ，ステロイド依存性喘息において低い傾向がみられた。また，年齢では39才以下，発症年齢では39才以下でヒズタミン遊離がより高い傾向がみられた。(3)血清IgE値の高い症例の好塩基球は，低い症例に比べより多くのヒスタミンを遊離する傾向がみられた。(4)全般的には，抗ヒトIgE刺激によるヒスタミン遊離とCaI刺激時の遊離との間にはある程度の相関がみられた。以上の結果より，好塩基球の反応性はいろいろの条件下でかなり異なることが示唆された。 kn-abstract=The release of histamine from basophils induced by anti-lgE and calcium ionophore A 23187 ( Cal) was examined in 27 patients with bronchial asthma and 7 healthy subjects, using a whole blood method. (1)The release of histamine induced by anti-IgE and CaI was significantly higher in atopic asthmatics than in non-atopic cases. (2) The histamine release with anti-lgE and CaI was significantly lower in cases with long-term steroid therapy compared to the release in cases without steroid therapy. (3) The release with anti-lgE and CaI was increased in cases with age of 0-39 years and in cases wpth age at onset of 0-39 years. (4) Anti-IgE induced release correlated to a certain extent with the release induced by CaI. These results show that basophil reactivity as expressed by histamine release changes under different conditions. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=6 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=7 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=8 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=Histamine release (ヒスタミン遊離) kn-keyword=Histamine release (ヒスタミン遊離) en-keyword=Basophils (好塩基球) kn-keyword=Basophils (好塩基球) en-keyword=Anti-lgE (抗ヒトIgE) kn-keyword=Anti-lgE (抗ヒトIgE) en-keyword=Calcium ionophore A 23187 (カルシウムイオノフォァA23187) kn-keyword=Calcium ionophore A 23187 (カルシウムイオノフォァA23187) en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=30 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=In Vitro Rooting and Multiple Buds Formation from Asparagus Lateral Buds with Ancymidol kn-title=典型的な臨床症状を呈さない肺結核症に対する気管支肺胞洗浄法（BAL）の診断学的意義 en-subtitle= kn-subtitle= en-abstract= kn-abstract=高齢者の増加やいわゆるcompromised　hostの増加により，肺結核症の臨床像が変化してきている。肺結核に典型的な臨床像を呈さず，頻回の喀疾検査にても抗酸菌を証明できなかった6症例に対し，気管支肺胞洗浄（bronchoalveolar lavage：BAL）を施行し，得られた洗浄液・吸引液の塗抹標本から抗酸菌を証明し，気管支粘膜の変化を認めた。以上の結果より，気管支型の結核症が増加してきている可能性が考えられた。気管支肺胞洗浄は，気管支型の結核症を含め，結核症の診断に有効と考えられた。 en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=肺結核 (Pulmonary tuberculosis) kn-keyword=肺結核 (Pulmonary tuberculosis) en-keyword=気管支型結核症 (Tuberculosis of mucous membrane) kn-keyword=気管支型結核症 (Tuberculosis of mucous membrane) en-keyword=気管支肺胞洗浄法 (Bronchoalveolar lavage) kn-keyword=気管支肺胞洗浄法 (Bronchoalveolar lavage) en-keyword=抗酸菌 (Acid fast bacilli) kn-keyword=抗酸菌 (Acid fast bacilli) END