岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
表紙
EN
Institute for Thermal Spring Research, Okayama University
No potential conflict of interest relevant to this article was reported.
岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
目次
EN
Institute for Thermal Spring Research, Okayama University
No potential conflict of interest relevant to this article was reported.
岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
切除標本の写真撮影
1
3
EN
Yasuharu
Noishiki
10.18926/21188
Histochemical, biochemical, and electron microscopic investigations on resected specimen have expanded in almost exponential manner in the past ten years and taking photograph of the specimens is also of importance for the examination of them. The specimens are, however, damaged during the time of taking photograph by various factors such as heat, dryness, light etc. For the investigations of this kind, the most important requirement for preservation of protoplasmic structure is to interrupt the dynamic process of the cell as prompt as possible and to stabilize the structure with a minimum of change. To prevent the damage of the specimens during the time of taking photograph, the following procedure is proposed: The specimen is dipped into cold saline solution, phosphate buffer, or cacodylate buffer. as soon as possible after operation. Photographic procedure is carried out upon the specimen dipped into the solution. By this procedure, the specimens can be protected from being damaged by heating and drying. Furthermore, the specimen can be preserved in its original shape due to the aid of buoyancy. This procedure has an another advantage : The photograph is in principle free from halation on the surface of the specimens. Thus, the proposed procedure is very useful for taking photograph of resected specimens in general.
No potential conflict of interest relevant to this article was reported.
岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
慢性関節リウマチの耳科・咽喉科領域における障害について 第1報 : 慢性関節リウマチ患者における聴力障害について
5
24
EN
Rei
Oda
10.18926/21189
Since Copeman's report on patients with hearing impairment as "rheumatoid otoarthritis?" has introduced, there have been a few reports on hearing impairment in patients with rheumatoid arthritis such as Goodwill et al. and Djupesland et aI. in European countries. On the contrary in our country there is no reference in association with hearing impairment of rheumatoid arthritis in rheumatic or otological literatures. An audiometric survey was carried out in 76 patients admitted in the Misasa branch hospital of Okayama university school of medicine on the classical or definite rheumatoid arthritis. Patients were excluded from the series if they had scarred or perforated tympanic membrane and history of otorrhea. Thus 67 patients have come to study. As control group, 15 healthy persons in hearing for each ten years, 15-24, 25-34, 35-44, 45-54, 55-64, and over 60 years, were selected and as a physiological hearing limit, rejection limit of hearingloss in dB. was made. Among 67 patients, 111 ears had hearingloss within the above mentioned rejection limit. In 23 ears, hearingloss in dB. were partial or as a whole out of the limit. They have all air-bone-conduction gap. After inflation of Eustachien tube, in most of them air conduction ability showed nearly the same level of bone conduction. In three cases even by inflation, airconduction level did not move. In one case the left side had effusion liquid and its RAreaction was positive. TwO of the former patients and the one whose effusion liquid had positive RA-test followed up for about 3 years. In the former two cases, hearing impairment got worse little by little and recovery by inflation was not seen. On both cases Gelle's test was positive. In the latter hearing impairment slowly got worse. This had lasted for about two months and had recoverd. In the se four cases heairng impairment was probably related to the rheumatoid arthritis and no other causes could be found.
No potential conflict of interest relevant to this article was reported.
岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
岡山県北部奥津花崗閃緑岩体の岩石学的研究 ― その1 地質及び岩石記載 ―
33
40
EN
Tooru
Sakiyama
10.18926/21191
The Late Mesozoic granitic rocks have been studied in the Okutsu area, northern Okayama Prefecture. Main portion of the area is occupied by the Okutsu granodioritic mass. It consists of mediumgrained hornblende-biotite granodiorite, mediumgrained biotite granite, fine-grained biotite granite, and aplitic granite in the succeeding order of intrusion. Contacts between these rock-types are generally gradational and An-contents of both core and margin of the plagioclase progressively decrease with increasing acidity of the rocks. These facts indicate a cognate origin of various rock-types of this mass. The Kamisaibara granite, rather uniform coarse-grained hornblende-biotite granite, occurs in large batholith. It is inferred petrographically that the Kamisaibara granite is a member of the Ningy6,t6ge granite widely distributed on the north of this area. Field evidence suggests that the Ningyo-toge granite was intruded by the Okutsu granodioritic mass.
No potential conflict of interest relevant to this article was reported.
岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
慢性関節リウマチとT-リンパ球―末梢血,関節液中の分布と免疫抑制剤のおよぼす影響について―
41
48
EN
Masaaki
Tokioka
Kiyoshi
Takasugi
10.18926/21192
Gradient centrifugation was quite useful in obtaining "mononuclear" cell fractions from synovial fluids derived from patients with rheumatoid arthritis. The ratio of lymphocytes to monocytoid cells was similar to that seen in peripheral blood. Prior treatment of the fluid with hyaluronidase was found to be necessary to obtain a satisfactory yield of the cells. Sheep erythrocyte rosette-forming lymphocytes (T-cells) were studied in 18 paired samples of synovial fluid and blood in RA and 15 control blood samples from normal persons were also examined. In the paired synovial fluid and blood samples from the RA patients, the mean percentages of the T-cells were 56.6 and 47.1 respectively and the difference was statistically significant (0.01<p<0.05). There was no significant difference between T-cell percentages in rheumatoid and control peripheral blood. In two RA patients receiving cyclophosphamide over an average period of 20 weeks, sequential studies of T-cells were performed on both the blood and synovial fluid. By the tenth week of treatment, they were markedly reduced in both synovial fluid and peripheral blood. By the 12th to the 15th week, however, at a time when the cumulative dose of cyclophosphamide was 5,000 mg, a rebound increase in T-cells was observed in the synovial effusion. The numbers of the T-cells in the blood concomitantly showed only a minimal rebound.
No potential conflict of interest relevant to this article was reported.
岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
各種岩石,鉱物および粘土の研磨薄片製作法
49
54
EN
Hitoshi
Asada
10.18926/21193
Making of polished thin section is improved by application of overturn pasting and grinding by rounding wet emery cloth.
No potential conflict of interest relevant to this article was reported.
岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
北海道の温泉ならびに火山についての同位体化学的調査報告
55
67
EN
Osamu
Matsubaya
Hitoshi
Sakai
Akira
Ueda
Makoto
Tsutsumi
Minoru
Kusakabe
Akira
Sasaki
10.18926/21194
Stable isotope ratios of hydrogen, oxygen, carbon and sulfur of precipitation, thermal and mineral waters, and volcanic gases were measured. The isotopic data combined with chemical and geological information were discussed in terms of origin and evolution of the hotsprings and volcanic gases. The hotsprings along the Uchiura Bay, Oshima Peninsula are mostly near-neutral NaCl-type thermal water and may be divided into three groups : (1) thermal waters isotopically similar to the precipitation of this area, (2) those similar in D/H to the local meteoric waters but enriched by 2 to 3‰ in (18)O compared to the latter, and (3) those enriched significantly in both D and (18)O relative to the local meteoric waters. The first and second types of thermal water probably form from local meteoric water which percolates through "Green Tuff" formations and acquires dissolved chemicals from them. However, high salt concentration and the oxygen isotope shift (thesecond type) may imply that the NaCl-type water of volcanic origin might be involved. On the other hand, the waters of the third group can be explained by mixing of modern sea water into the second type thermal water (in case of Yachigashira) or by incorporation of fossil sea water of Tertiary origin into modern meteoric water (Nigorigawa). Except for Esan, Noboribetsu and Atosanupuri volcanic systems, waters from all the hotsprings and volcanic fumaroles associated with Quaternary volcanic rocks are meteoric in origin. Thermal waters at Esan, Noboribetsu and Atosanupuri have δD = -30〜-50 and δ(18)O = -1〜+ 3‰ and are enriched in D and (18)O relative to local meteoric water of the respective area. The origin of these waters and the mechanism (s) controlling the isotope ratios could not be made clear by the present study. Interesting is the finding that at Esan, Noboribetsu and Atosanupuri, thermal waters are enriched in D and (18)O relative to near-by fumarolic gases. The enrichment factor is 18 to 26‰ for hydrogen and 4 to 6‰ for oxygen, implying that more than one stages of liquidvapor separation are taking place in underground hydrothermal systems.
No potential conflict of interest relevant to this article was reported.
岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
慢性関節リウマチにおけるD-Penicillamine療法
69
75
EN
Hirofumi
Ishii
Kiyoshi
Takasugi
Minoru
Kitayama
Hiroshi
Morinaga
10.18926/21195
Twenty patients with classical or definite rheumatoid arthritis were treated with D-Penicillamine. Favorable responses were observed in 75% of the patients. Significant improvement in clinical parameters, such as ESR, CRP, titers of rheumatoid factor and so forth, was noticed in twenty weeks of treatment. Withdrawal from penicillamine treatment was necessitated in four patients because of adverse reactions to the drug. Untoward effects included skin rash (most frequent), pruritis and loss of taste. From this preliminary study we presume that in earlier cases in which rheumatoid lesions may be reversible, more favorable clinical effects would be expected from this agent.
No potential conflict of interest relevant to this article was reported.
岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
奥付
EN
Institute for Thermal Spring Research, Okayama University
No potential conflict of interest relevant to this article was reported.
岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
裏表紙
EN
Institute for Thermal Spring Research, Okayama University
No potential conflict of interest relevant to this article was reported.
岡山大学温泉研究所
Acta Medica Okayama
0369-7142
47
1978
慢性関節リウマチの耳科・咽喉科領域における障害について 第2報 : 慢性関節リウマチ患者の喉頭所見について
25
32
EN
Rei
Oda
10.18926/40076
Until 1955 a few reports had been made concerning this problem. On December
1955. Montgomery, Perone and Schall reported
four cases of rheumatoid arthritis of cricoarytenoid joint. It seemed to have interested other authors so that Saunders, Pearson, BakerBywaters, Copeman and Polisar reported their clinical findings. In 1957 Pearson presented a histological section
of cricoarytenoid joint, showing villous synovial
proliferation. In 1959 Montgomery reported
another series of additional cases and microscopical findings of the cricoarytenoid joint of two patients with rheumatoid arthritis. This study did not show a complete fibrous ankylosis but severe arthritic changes were seen. In the same year Copeman et al. reported an autopsy case of rheumatoid arthritis with ankylosis of cricoarytenoid joint. In early 1960's Grossman et al. examined 55 patients with rheumatoid arthritis and found 18 patients with some suggestive evidence of cricoarytenoid arthritis. Lofgren and Montgomery examined 100 patients of rheumatoid arthritis, finding 26% of them had involvement of cricoarytenoid joint. They stated that this disease seemed to be more common and more severe in female. Bienenstock stated 17 cases of 64 randomly selected patients with rheumatoid arthritis had one or more symptoms considered to be characteristic of cricoarytenoid arthritis. He claimed that arthritis of cricoarytenoid joint occured much more frequently in patients with rheumatoid
arthritis than had been suspected. At postmortem examination Grossman saw histological changes of cricoarytenoid joint characteristics of rheumatoid arthritis in 5 of 11 autopsied patients with rheumatoid arthritis and Bienenstock found the same in 7 of 8 patients. In
1963 for the third time Montgomery discussed of
cricoarytenoid arthritis, based on his own
experiences and many available literatures.
Pathologic changes range between the mere
synovial thickning and the complete disruption.
Montgomery believed as others did, that in
ankylosing chronic stage inspiratory bowing of
both vocal cords and absolute fixation of arytenoid cartilage were diagnostic signs of rheumatoid arthritis of cricoarytenoid joint.
In 1958 Darke, Wolman and Young reported five
cases of laryngeal stridor, where in four cases
tracheotomy became necessary. Two of them
were brought to autopsy and histological examination. They found evidence of the nerve
degeneration and mobile cricoarytenoid joint.
The cause of nerve degeneration in the second
case was an ischaemic neuropathy from rheumatoid
arteritis of vasa nervorum. These findings
were different from those of Montgomery and
others. In 1965 Wolman, Darke and Young had an
opportunity of six more autopsy examples. They
confirmed from their own pathologic findings that
laryngeal stridor occuring in rheumatoid
arthritis was due mainly to arteritis of the vasa
nervorum causing ischaemic neuropathy and that
polymyositis and joint disease might augment
this effect. Woldorf and Webb et aI. introduced
both of these opinions. Anyhow, in U. S. A. and in England 25%-28% of rheumatoid arthritis seems to have rheumatoid arthritis of cricoarytenoid joint. On the other hand in our country there has been seen no report on rheumatoid arthritis of cricoarytenoid joint. In order, therefore, to investigate this problem author examined in medical clinic of Misasa branch hospital of Okayama university school of medicine 76 patients of classical and definite rheumatoid arthritis. Their complaints were as follows.
1) dryfeeling of throat 17 (22.4%) 2) slight hoarseness 11 (14.5%) 3) choking by long conversation 1 (1.32%) 4) slight dysphagia 2 (2.6%) The larynx was mirrored indirectly by Türk's, Killian's and Avellis's position. Any redness, swelling of mucous membrane, abnormality of vocal cords and arytenoid cartilage were not found.
No potential conflict of interest relevant to this article was reported.