start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page=25 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The involvement of ear and throat in rheumatoid arthritis II. On the Rheumatoid Arthritis of Cricoaryenoid Joint kn-title=慢性関節リウマチの耳科･咽喉科領域における障害について 第2報 : 慢性関節リウマチ患者の喉頭所見について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Until 1955 a few reports had been made concerning this problem. On December 1955. Montgomery, Perone and Schall reported four cases of rheumatoid arthritis of cricoarytenoid joint. It seemed to have interested other authors so that Saunders, Pearson, BakerBywaters, Copeman and Polisar reported their clinical findings. In 1957 Pearson presented a histological section of cricoarytenoid joint, showing villous synovial proliferation. In 1959 Montgomery reported another series of additional cases and microscopical findings of the cricoarytenoid joint of two patients with rheumatoid arthritis. This study did not show a complete fibrous ankylosis but severe arthritic changes were seen. In the same year Copeman et al. reported an autopsy case of rheumatoid arthritis with ankylosis of cricoarytenoid joint. In early 1960's Grossman et al. examined 55 patients with rheumatoid arthritis and found 18 patients with some suggestive evidence of cricoarytenoid arthritis. Lofgren and Montgomery examined 100 patients of rheumatoid arthritis, finding 26% of them had involvement of cricoarytenoid joint. They stated that this disease seemed to be more common and more severe in female. Bienenstock stated 17 cases of 64 randomly selected patients with rheumatoid arthritis had one or more symptoms considered to be characteristic of cricoarytenoid arthritis. He claimed that arthritis of cricoarytenoid joint occured much more frequently in patients with rheumatoid arthritis than had been suspected. At postmortem examination Grossman saw histological changes of cricoarytenoid joint characteristics of rheumatoid arthritis in 5 of 11 autopsied patients with rheumatoid arthritis and Bienenstock found the same in 7 of 8 patients. In 1963 for the third time Montgomery discussed of cricoarytenoid arthritis, based on his own experiences and many available literatures. Pathologic changes range between the mere synovial thickning and the complete disruption. Montgomery believed as others did, that in ankylosing chronic stage inspiratory bowing of both vocal cords and absolute fixation of arytenoid cartilage were diagnostic signs of rheumatoid arthritis of cricoarytenoid joint. In 1958 Darke, Wolman and Young reported five cases of laryngeal stridor, where in four cases tracheotomy became necessary. Two of them were brought to autopsy and histological examination. They found evidence of the nerve degeneration and mobile cricoarytenoid joint. The cause of nerve degeneration in the second case was an ischaemic neuropathy from rheumatoid arteritis of vasa nervorum. These findings were different from those of Montgomery and others. In 1965 Wolman, Darke and Young had an opportunity of six more autopsy examples. They confirmed from their own pathologic findings that laryngeal stridor occuring in rheumatoid arthritis was due mainly to arteritis of the vasa nervorum causing ischaemic neuropathy and that polymyositis and joint disease might augment this effect. Woldorf and Webb et aI. introduced both of these opinions. Anyhow, in U. S. A. and in England 25%-28% of rheumatoid arthritis seems to have rheumatoid arthritis of cricoarytenoid joint. On the other hand in our country there has been seen no report on rheumatoid arthritis of cricoarytenoid joint. In order, therefore, to investigate this problem author examined in medical clinic of Misasa branch hospital of Okayama university school of medicine 76 patients of classical and definite rheumatoid arthritis. Their complaints were as follows. 1) dryfeeling of throat 17 (22.4%) 2) slight hoarseness 11 (14.5%) 3) choking by long conversation 1 (1.32%) 4) slight dysphagia 2 (2.6%) The larynx was mirrored indirectly by T?rk's, Killian's and Avellis's position. Any redness, swelling of mucous membrane, abnormality of vocal cords and arytenoid cartilage were not found. en-copyright= kn-copyright= en-aut-name=OdaRei en-aut-sei=Oda en-aut-mei=Rei kn-aut-name=小田ﾔ kn-aut-sei=小田 kn-aut-mei=ﾔ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Thermal Spring Research, Okayama University en-aut-sei=Institute for Thermal Spring Research, Okayama University en-aut-mei= kn-aut-name=岡山大学温泉研究所 kn-aut-sei=岡山大学温泉研究所 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=奥付 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Thermal Spring Research, Okayama University en-aut-sei=Institute for Thermal Spring Research, Okayama University en-aut-mei= kn-aut-name=岡山大学温泉研究所 kn-aut-sei=岡山大学温泉研究所 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page=69 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The treatment of rheumatoid arthritis with D-penicillamine. Preliminary report kn-title=慢性関節リウマチにおけるD-Penicillamine療法 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty patients with classical or definite rheumatoid arthritis were treated with D-Penicillamine. Favorable responses were observed in 75% of the patients. Significant improvement in clinical parameters, such as ESR, CRP, titers of rheumatoid factor and so forth, was noticed in twenty weeks of treatment. Withdrawal from penicillamine treatment was necessitated in four patients because of adverse reactions to the drug. Untoward effects included skin rash (most frequent), pruritis and loss of taste. From this preliminary study we presume that in earlier cases in which rheumatoid lesions may be reversible, more favorable clinical effects would be expected from this agent. en-copyright= kn-copyright= en-aut-name=IshiiHirofumi en-aut-sei=Ishii en-aut-mei=Hirofumi kn-aut-name=石井廣文 kn-aut-sei=石井 kn-aut-mei=廣文 aut-affil-num=1 ORCID= en-aut-name=TakasugiKiyoshi en-aut-sei=Takasugi en-aut-mei=Kiyoshi kn-aut-name=高杉潔 kn-aut-sei=高杉 kn-aut-mei=潔 aut-affil-num=2 ORCID= en-aut-name=KitayamaMinoru en-aut-sei=Kitayama en-aut-mei=Minoru kn-aut-name=北山稔 kn-aut-sei=北山 kn-aut-mei=稔 aut-affil-num=3 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=3 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=4 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page=55 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stable isotope study of the hotsprings and volcanoes of Hokkaido, Japan kn-title=北海道の温泉ならびに火山についての同位体化学的調査報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Stable isotope ratios of hydrogen, oxygen, carbon and sulfur of precipitation, thermal and mineral waters, and volcanic gases were measured. The isotopic data combined with chemical and geological information were discussed in terms of origin and evolution of the hotsprings and volcanic gases. The hotsprings along the Uchiura Bay, Oshima Peninsula are mostly near-neutral NaCl-type thermal water and may be divided into three groups : (1) thermal waters isotopically similar to the precipitation of this area, (2) those similar in D/H to the local meteoric waters but enriched by 2 to 3‰ in (18)O compared to the latter, and (3) those enriched significantly in both D and (18)O relative to the local meteoric waters. The first and second types of thermal water probably form from local meteoric water which percolates through "Green Tuff" formations and acquires dissolved chemicals from them. However, high salt concentration and the oxygen isotope shift (thesecond type) may imply that the NaCl-type water of volcanic origin might be involved. On the other hand, the waters of the third group can be explained by mixing of modern sea water into the second type thermal water (in case of Yachigashira) or by incorporation of fossil sea water of Tertiary origin into modern meteoric water (Nigorigawa). Except for Esan, Noboribetsu and Atosanupuri volcanic systems, waters from all the hotsprings and volcanic fumaroles associated with Quaternary volcanic rocks are meteoric in origin. Thermal waters at Esan, Noboribetsu and Atosanupuri have δD = -30〜-50 and δ(18)O = -1〜+ 3‰ and are enriched in D and (18)O relative to local meteoric water of the respective area. The origin of these waters and the mechanism (s) controlling the isotope ratios could not be made clear by the present study. Interesting is the finding that at Esan, Noboribetsu and Atosanupuri, thermal waters are enriched in D and (18)O relative to near-by fumarolic gases. The enrichment factor is 18 to 26‰ for hydrogen and 4 to 6‰ for oxygen, implying that more than one stages of liquidvapor separation are taking place in underground hydrothermal systems. en-copyright= kn-copyright= en-aut-name=MatsubayaOsamu en-aut-sei=Matsubaya en-aut-mei=Osamu kn-aut-name=松葉谷治 kn-aut-sei=松葉谷 kn-aut-mei=治 aut-affil-num=1 ORCID= en-aut-name=SakaiHitoshi en-aut-sei=Sakai en-aut-mei=Hitoshi kn-aut-name=酒井均 kn-aut-sei=酒井 kn-aut-mei=均 aut-affil-num=2 ORCID= en-aut-name=UedaAkira en-aut-sei=Ueda en-aut-mei=Akira kn-aut-name=上田晃 kn-aut-sei=上田 kn-aut-mei=晃 aut-affil-num=3 ORCID= en-aut-name=TsutsumiMakoto en-aut-sei=Tsutsumi en-aut-mei=Makoto kn-aut-name=堤真 kn-aut-sei=堤 kn-aut-mei=真 aut-affil-num=4 ORCID= en-aut-name=KusakabeMinoru en-aut-sei=Kusakabe en-aut-mei=Minoru kn-aut-name=日下部実 kn-aut-sei=日下部 kn-aut-mei=実 aut-affil-num=5 ORCID= en-aut-name=SasakiAkira en-aut-sei=Sasaki en-aut-mei=Akira kn-aut-name=佐々木昭 kn-aut-sei=佐々木 kn-aut-mei=昭 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所熱水地球化学部門 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所熱水地球化学部門 affil-num=3 en-affil= kn-affil=岡山大学温泉研究所熱水地球化学部門 affil-num=4 en-affil= kn-affil=岡山大学温泉研究所熱水地球化学部門 affil-num=5 en-affil= kn-affil=東京工業大学 affil-num=6 en-affil= kn-affil=地質調査所 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page=49 end-page=54 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Some improvements in making of polished thin section kn-title=各種岩石,鉱物および粘土の研磨薄片製作法 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Making of polished thin section is improved by application of overturn pasting and grinding by rounding wet emery cloth. en-copyright= kn-copyright= en-aut-name=AsadaHitoshi en-aut-sei=Asada en-aut-mei=Hitoshi kn-aut-name=麻田斉 kn-aut-sei=麻田 kn-aut-mei=斉 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉地質学部門 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page=41 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Enumeration of T-cells in peripheral blood as well as in joint fluid from patients with rheumatoid arthritis (RA) and the effect of cyclophosphamide kn-title=慢性関節リウマチとT-リンパ球―末梢血,関節液中の分布と免疫抑制剤のおよぼす影響について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Gradient centrifugation was quite useful in obtaining "mononuclear" cell fractions from synovial fluids derived from patients with rheumatoid arthritis. The ratio of lymphocytes to monocytoid cells was similar to that seen in peripheral blood. Prior treatment of the fluid with hyaluronidase was found to be necessary to obtain a satisfactory yield of the cells. Sheep erythrocyte rosette-forming lymphocytes (T-cells) were studied in 18 paired samples of synovial fluid and blood in RA and 15 control blood samples from normal persons were also examined. In the paired synovial fluid and blood samples from the RA patients, the mean percentages of the T-cells were 56.6 and 47.1 respectively and the difference was statistically significant (0.01