The disappearance rates(K) of FT-207 from the blood in patients with primary hepatoma and advanced cirrhosis of the liver were significantly lower than those in control patients with cancer but normal liver function. Pretreatment with tocopheryl nicotinate and indomethacin increased the K values in the control subjects, but was without effect on the K values in patients with primary hepatoma.
en-copyright= kn-copyright= en-aut-name=HobaraNorio en-aut-sei=Hobara en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeAkiharu en-aut-sei=Watanabe en-aut-mei=Akiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University en-keyword=FT-207 kn-keyword=FT-207 en-keyword=disappearance rate kn-keyword=disappearance rate en-keyword=hepatoma kn-keyword=hepatoma en-keyword=liver cirrhosis kn-keyword=liver cirrhosis en-keyword=tocophery1 nicotinate kn-keyword=tocophery1 nicotinate en-keyword=indomethacin kn-keyword=indomethacin END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=5 article-no= start-page=409 end-page=413 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Preparation of anti-rat albumin antiserum and its application to radioimmunoassay. en-subtitle= kn-subtitle= en-abstract= kn-abstract=Albumin was highly purified from a commercially available rat albumin preparation (Fraction V) using disc electrophoresis. The purified albumin had the same antigenicity as Fraction V. A monospecific anti-rat albumin rabbit serum was obtained. The antiserum was used in a double antibody quantitative method for determining rat albumin.
en-copyright= kn-copyright= en-aut-name=MiyazakiMasahiro en-aut-sei=Miyazaki en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeAkiharu en-aut-sei=Watanabe en-aut-mei=Akiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SyarifuddinWahid en-aut-sei=Syarifuddin en-aut-mei=Wahid kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsunashimaMasakazu en-aut-sei=Tsunashima en-aut-mei=Masakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoJiro en-aut-sei=Sato en-aut-mei=Jiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Unversity affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=rat albumin kn-keyword=rat albumin en-keyword=anti-rat albumin antiserum kn-keyword=anti-rat albumin antiserum en-keyword=radioimmunoassay kn-keyword=radioimmunoassay en-keyword=double antibody method kn-keyword=double antibody method END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=5 article-no= start-page=269 end-page=285 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Lipoprotein abnormalities in cholestasis. I. Electrophoretic and ultracentrifugal analyses. en-subtitle= kn-subtitle= en-abstract= kn-abstract=The alterations of lipid composition in sera of patients with liver diseases, particularly intrahepatic cholestasis and biliary obstruction, were studied by ultracentrifugation and polyacrylamide-gel disc-electrophoresis of lipoproteins and apoproteins. The elevation of serum cholesterol in intrahepatic cholestasis was greater than in biliary obstruction. The appearance of lipoprotein X in obstructive disease accounted for most of the increased cholesterol. The level of non-lipoprotein X cholesterol in intrahepatic cholestasis was significantly elevated, this being in part ascribed to the appearance of a new class of cholestatic lipoprotein, Slow-migrating HDL. The electrophoretic pattern of lipoprotein in cholestasis was generally characterized by a decrease in alpha band intensity and, in some types of cholestasis, by the appearance of Slow-migrating HDL. In addition, other abnormal lipoproteins exhibiting the characteristics of triglyceride-rich LDL (LP-Y), LP-X-like HDL and LDL-like HDL were found in some cases of intrahepatic cholestasis and biliary obstruction.
en-copyright= kn-copyright= en-aut-name=WatanabeMakoto en-aut-sei=Watanabe en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University en-keyword=intrahepatic cholestasis kn-keyword=intrahepatic cholestasis en-keyword=primary biliary cirrhosis kn-keyword=primary biliary cirrhosis en-keyword=polyacrylamide-gel disc-electrophoresis kn-keyword=polyacrylamide-gel disc-electrophoresis en-keyword=high density lipoprotein kn-keyword=high density lipoprotein en-keyword= Slow-migrating HDL(HDL-S) kn-keyword= Slow-migrating HDL(HDL-S) END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=5 article-no= start-page=371 end-page=377 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of vagotomy on feeding and defecation in guinea pigs. en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effect of subdiaphragmatic vagotomy on food intake and defecation was studied in guinea pigs. Weights of food and feces were measured for at least three weeks after vagotomy. The weight of daily food intake and feces evacuated increased about 15 and 30% after vagotomy compared with controls whereas it did not change in sham operated animals. The weight of scybalum decreased after vagotomy although the number increased markedly. It was considered that an increase in food intake after vagotomy may result from blocking of satiety signals mediated by the vagus; moreover, that the increase in feces may depend on the enhancement of scybalum formation in the proximal colon resulting from increasing food intake and transportation of the larger amount of the contents after vagotomy.
en-copyright= kn-copyright= en-aut-name=NeyaToshiaki en-aut-sei=Neya en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakaiMiyako en-aut-sei=Takai en-aut-mei=Miyako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakayamaSosogu en-aut-sei=Nakayama en-aut-mei=Sosogu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=vagotomy kn-keyword=vagotomy en-keyword=food intake kn-keyword=food intake en-keyword=defecation kn-keyword=defecation END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=5 article-no= start-page=359 end-page=370 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The tumor-forming type of multiple myeloma. I. Biological behavior. en-subtitle= kn-subtitle= en-abstract= kn-abstract=A total of 45 cases of multiple myeloma has been followed up clinically during the period from 7 to 80 months. Out of these, six patients (13.3%) were diagnosed to be the tumor-forming type; they developed discrete tumor formation at the disease onset or during clinical observation. Biological behavior of these cases is briefly outlined. Histologically, five cases presented with well or moderately well differentiated plasma cells according to the grading made by Pasmantier and Azar. The remaining one case was poorly differentiated in cell maturity, and with electron and immunofluorescence microscopies, proved to be of plasmacytic nature.
en-copyright= kn-copyright= en-aut-name=TanakaToshio en-aut-sei=Tanaka en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SezakiTatsuo en-aut-sei=Sezaki en-aut-mei=Tatsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HujitaMineji en-aut-sei=Hujita en-aut-mei=Mineji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkaAkira en-aut-sei=Oka en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoTsukasa en-aut-sei=Okamoto en-aut-mei=Tsukasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ItoJishu en-aut-sei=Ito en-aut-mei=Jishu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=National Okayama Hospital affil-num=3 en-affil= kn-affil=Chugoku Central Hospital affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=National Fukuyama Hospital affil-num=6 en-affil= kn-affil=Kawasaki Hospital en-keyword=tomor-forming tupe kn-keyword=tomor-forming tupe en-keyword=multiple myeloma kn-keyword=multiple myeloma END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=5 article-no= start-page=287 end-page=304 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The mechanism of the release of hepatic enzymes in various liver diseases. 1. Alterations in cytoplasmic and mitochondrial enzyme activities in serum. en-subtitle= kn-subtitle= en-abstract= kn-abstract=Serum glutamic oxaloacetic transaminase (GOT), mitochondrial GOT (GOTm), glutamic-pyruvic transaminase (GPT) and glutamate dehydrogenase activities were determined in 43 healthy controls and in 280 cases of liver diseases. A simplified column chromatographic method coupled with UV assay was employed for separation of GOTm. The activity was measured by following decrease in abosrbance of NADH at 340 nm. The lowest activity of GOTm determined with a coefficient of variation below 10% was 6 mIU/ml. High GOTm activities were found in acute hepatitis (acute stage), subacute hepatitis and primary biliary cirrhosis and were generally associated with high total GOT (GOTt) activities. The activity ratio of GOTm/GOTt varied depending on the stage and severity of liver diseases. The GOTm/GOTt ratio was decreased in acute, fulminant and subacute hepatitides. No significant reduction in the ratio was found in bile duct obstruction, alcoholic liver injury or metastatic liver cancer. Although relatively high GOTm/GOTt ratios were found in some patients with severe hepatic injury, they had no definite association with poor prognosis. These results indicate that the marked elevation in GOTt over GPT in advanced chronic hepatitis, liver cirrhosis and primary hepatoma was mainly due to preferential leakage of cytoplasmic GOT (GOTs).
en-copyright= kn-copyright= en-aut-name=MiyakeShu en-aut-sei=Miyake en-aut-mei=Shu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University en-keyword=glutamic-oxaloacetic transaminanse kn-keyword=glutamic-oxaloacetic transaminanse en-keyword=glutamic-pyruvic transaminase ratio kn-keyword=glutamic-pyruvic transaminase ratio en-keyword=glutamic-oxaloacetic transaminase isoenzyme kn-keyword=glutamic-oxaloacetic transaminase isoenzyme en-keyword=enzyne leakage kn-keyword=enzyne leakage en-keyword=liver enzyme kn-keyword=liver enzyme en-keyword=enzyme dedifferentiation kn-keyword=enzyme dedifferentiation en-keyword=liver diseases kn-keyword=liver diseases END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=5 article-no= start-page=405 end-page=407 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tumor induction in Swiss mice by filtrable agent and Salmonella typhimurium. en-subtitle= kn-subtitle= en-abstract= kn-abstract=Combined inoculation of a cell-free extract of leukotic tissue of D103 mice and Salmonella typhimurium into adult Swiss mice induced leukosis and solid tumors. The induced solid tumors were histologically multifarious, and were transplantable in Swiss mice, but not in other strains of mice.
en-copyright= kn-copyright= en-aut-name=HamazakiYukio en-aut-sei=Hamazaki en-aut-mei=Yukio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MuraoTsuyoshi en-aut-sei=Murao en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama City Hospital en-keyword=tumor kn-keyword=tumor en-keyword=cell-free extract kn-keyword=cell-free extract en-keyword=salmonella kn-keyword=salmonella END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=5 article-no= start-page=395 end-page=404 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Vectorcardiogram of complete right bundle branch block with left axis deviation by the Frank and Kimura systems. en-subtitle= kn-subtitle= en-abstract= kn-abstract=Vectorcardiogram (VCG) recorded by both the Frank and Kimura systems were examined in 45 patients with complete right bundle branch block (RBBB) and left axis deviation (LAD) to investigate the relationship seen on electrocardiogram (ECG) between RBBB with LAD and bilateral bundle. The sample included: 13 cases of type SI, SII, SIII, SaVF; 21 cases of type SI, SII, SIII, aVF; and 11 cases of types SI, SII, SIII. VCG recorded by the Frank system were classified into seven types according to the QRS loop pattern on the frontal plane and into three types according to the horizontal plane. The main findings were: (a) In the Frank system the QRS loop in the frontal plane showed a variety of patterns in RBBB with LAD. (b) On VCG of complete RBBB judged complicated by a left anterior hemiblock by the Frank system, the main portion of the QRS loop extended to the left superior or merely to the left in the frontal plane. The direction of rotation and position on the horizontal plane were not consistent. (c) The results of this study suggest the usefulness of the Kimura system as an auxiliary diagnostic technique.
en-copyright= kn-copyright= en-aut-name=NakagawaMasahiro en-aut-sei=Nakagawa en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SaitoDaiji en-aut-sei=Saito en-aut-mei=Daiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UedaMinoru en-aut-sei=Ueda en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshidaHidenori en-aut-sei=Yoshida en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MaeRitsuo en-aut-sei=Mae en-aut-mei=Ritsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IoriyaKazuo en-aut-sei=Ioriya en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HaraokaShoichi en-aut-sei=Haraoka en-aut-mei=Shoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University en-keyword=right bundle branch block kn-keyword=right bundle branch block en-keyword=left axis deviation kn-keyword=left axis deviation en-keyword=bilateral bundle branch block kn-keyword=bilateral bundle branch block en-keyword=vectorcardiography kn-keyword=vectorcardiography en-keyword=Frank system kn-keyword=Frank system en-keyword=Kimura system kn-keyword=Kimura system END