ID | 60775 |
フルテキストURL | |
著者 |
Tetsunaga, Tomoko
Department of Orthopedic Surgery, Okayama University Hospital
Nishida, Keiichiro
Department of Orthopedic Surgery, Okayama University Hospital
Kaken ID
publons
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Misawa, Haruo
Department of Orthopedic Surgery, Okayama University Hospital
Kaken ID
publons
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Takigawa, Tomoyuki
Department of Orthopedic Surgery, Okayama University Hospital
ORCID
Kaken ID
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Yamane, Kentaro
Department of Orthopedic Surgery, Okayama University Hospital
Tsuji, Hironori
Department of Orthopedic Surgery, Okayama University Hospital
Takei, Yoshitaka
Department of Orthopedic Surgery, Kurashiki Municipal Hospital
Ozaki, Toshifumi
Department of Orthopedic Surgery, Okayama University Hospital
Kaken ID
publons
researchmap
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抄録 | Background
Mirogabalin, which is approved for the treatment of peripheral neuropathic pain in Japan, is a ligand for the α2δ subunit of voltage-gated calcium channels. Both pregabalin and mirogabalin act as nonselective ligands at the α2δ-1 and α2δ-2 subunits. Mirogabalin has a unique binding profile and long duration of action. Pregabalin has been reported to produce intolerable adverse effects in some patients. This study investigated outcomes associated with mirogabalin administration in patients with peripheral neuropathic pain who ceased treatment with pregabalin.
Methods
We retrospectively assessed peripheral neuropathic pain using the neuropathic pain screening questionnaire (NeP score) in 187 patients (58 men, 129 women) who were treated with mirogabalin. All patients had switched from pregabalin to mirogabalin due to lack of efficacy or adverse events. Differences in the treatment course (i.e., numeric rating scale (NRS) scores) were compared using one-way analysis of variance with Bonferroni post hoc tests.
Results
The mean age of the patients was 72.3 years (range, 30–94 years), and the mean duration of disease was 37 months (range, 3–252 months). After treatment with mirogabalin for 1 week, NRS scores significantly decreased compared with baseline and continued to decrease over time. After 8 weeks, NRS scores improved by ≥ 30% from baseline in 113 patients (69.3%). Twenty-four patients (12.8%) stopped mirogabalin treatment due to adverse events. Somnolence (26.7%), dizziness (12.3%), edema (5.9%), and weight gain (0.5%) were noted as adverse events of mirogabalin.
Conclusions
The results of this investigation indicate that mirogabalin is safe and effective for reducing peripheral neuropathic pain.
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キーワード | Peripheral neuropathic pain
Mirogabalin
Pregabalin
Adverse event
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発行日 | 2020-05-26
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出版物タイトル |
Journal of Orthopaedic Surgery and Research
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巻 | 15巻
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号 | 1号
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出版者 | Springer
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開始ページ | 191
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ISSN | 1749-799X
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1186/s13018-020-01709-3
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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