start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=3
article-no=
start-page=735
end-page=747
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Associations among baseline variables, treatment-related factors and health-related quality of life 2 years after breast cancer surgery
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Provision of social support and rehabilitation for
patients with physical, mental, and functional problems after cancer treatment is important for long-term health-related quality of life (HRQOL). Effective use of human and financial healthcare resources requires identification of patients requiring rehabilitation. The objectives of the current study were to clarify the patterns of physical and psychosocial recovery over time, to evaluate the associations among baseline variables, treatment-related factors and
HRQOL at 6 months, 1, and 2 years after breast cancer surgery, and to identify the significant factors predicting HRQOL at each point. A multicenter longitudinal study was performed to evaluate physical conditions, anxiety, depression, and HRQOL at 1 month (baseline), 6 months, 1, and 2 years after surgery in 196 patients (mean age: 53.3 years old) with early breast cancer and no postoperative recurrence. Physical conditions were evaluated using a
patient-reported symptom checklist. HRQOL was rated using the functional assessment of cancer treatment scalegeneral (FACT-G) and the breast cancer subscale (FACTB). Anxiety and depression were rated using the hospital anxiety and depression scale (HADS). More than 50% of
patients had local problems of "tightness", "arm weakness." and "arm lymphedema", and systemic problems of "reduced energy, fatigue, and general weakness" postoperatively. The HRQOL score significantly improved 1 year after surgery, and scores for physical, emotional and functional
well-being also increased with time, whereas the score for social well-being was the highest at baseline and decreased with time. Depression and anxiety significantly improved with time. Concomitant disease, marital status, and the presence of a partner, anxiety and depression at
baseline, pathological lymph node involvement, and adjuvant intravenous chemotherapy were significant factors predicting FACT-G scores at 6 months, 1, and 2 years after surgery. Depression at baseline was a strong predictor of HRQOL up to 2 years after surgery. These results suggest
that physical rehabilitation is required for tightness and lymphedema to improve long-term postoperative physical function. A further study of psychosocial interventions is required to improve depression and social well-being after
breast cancer surgery.
en-copyright=
kn-copyright=

en-aut-name=TairaNaruto
en-aut-sei=Taira
en-aut-mei=Naruto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShimozumaKojiro
en-aut-sei=Shimozuma
en-aut-mei=Kojiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShiroiwaTakeru
en-aut-sei=Shiroiwa
en-aut-mei=Takeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OhsumiShozo
en-aut-sei=Ohsumi
en-aut-mei=Shozo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KuroiKatsumasa
en-aut-sei=Kuroi
en-aut-mei=Katsumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SajiShigehira
en-aut-sei=Saji
en-aut-mei=Shigehira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SaitoMitsue
en-aut-sei=Saito
en-aut-mei=Mitsue
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IhaShigemichi
en-aut-sei=Iha
en-aut-mei=Shigemichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=WatanabeTakanori
en-aut-sei=Watanabe
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KatsumataNoriyuki
en-aut-sei=Katsumata
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital

affil-num=2
en-affil=
kn-affil=Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University

affil-num=3
en-affil=
kn-affil=Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University

affil-num=4
en-affil=
kn-affil=Department of Breast Surgery, National Hospital Organization, National Shikoku Cancer Center

affil-num=5
en-affil=
kn-affil=Division of Clinical Trials and Research, Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital

affil-num=6
en-affil=
kn-affil=Division of Clinical Trials and Research, Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital

affil-num=7
en-affil=
kn-affil=Department of Breast Oncology, Juntendo University

affil-num=8
en-affil=
kn-affil=Department of Breast Surgery, Okayama Ofuku Clinic

affil-num=9
en-affil=
kn-affil=Department of Surgery, National Hospital Organization, Sendai Medical Center

affil-num=10
en-affil=
kn-affil=Department of Medical Oncology, National Cancer Center Hospital
en-keyword=Breast cancer
kn-keyword=Breast cancer
en-keyword=HRQOL
kn-keyword=HRQOL
en-keyword=Depression
kn-keyword=Depression
en-keyword=Anxiety
kn-keyword=Anxiety
en-keyword=Chemotherapy
kn-keyword=Chemotherapy
END