| ID | 32980 |
| フルテキストURL | |
| 著者 |
Itoh, Kanako
Department of Psychiatry, Chiba University Graduate School of Medicine
Hashimoto, Kenji
Department of Psychiatry, Chiba University Graduate School of Medicine
Shimizu, Eiji
Department of Psychiatry, Chiba University Graduate School of Medicine
Sekine, Yoshimoto
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine
Ozaki, Norio
Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine
Inada, Toshiya
Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine
Harano, Mutsuo
Department of Neuropsychiatry, Kurume University School of Medicine
Iwata, Nakao
Department of Psychiatry, Fujita Health University School of Medicine
Komiyama, Tokutaro
National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry
Yamada, Mitsuhiko
Karasuyama Hospital, Showa University School of Medicine
Sora, Ichiro
Division of Psychobiology, Tohoku University Graduate School of Medicine
Nakata, Kenji
Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry
Ujike, Hiroshi
Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry
Iyo, Masaomi
Department of Psychiatry, Chiba University Graduate School of Medicine
|
| 抄録 | Several lines of evidence suggest that genetic factors might contribute to drug abuse vulnerability. Recent genomic scans for association demonstrated that the brain-derived neurotrophic factor (BDNF) gene was associated with drug abuse vulnerability. In this study, we analyzed association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C>T (C270T named formerly) in the noncoding region of exon V and 196G >A (val66met) in the coding region of exon XIIIA, with methamphetamine (MAP) abuse in Japan. No significant differences were found in the frequency of the genotype or allele in these two SNPs between MAP abusers and controls (132C>T in exon V: genotype, p = 0.586, allele, p = 0.594; 196G>A (val66met) in exon XIIIA: genotype, p = 0.889, allele, p = 0.713). Furthermore, there was no difference between clinical parameters (e.g. prognosis psychosis, spontaneous relapse, or poly-substance abuse) and the two SNPs of BDNF gene. These results suggest that the two SNPs (132C>T in exon V and 196G>A (val66met) in exon XIIIA) of the BDNF gene may not be associated with Japanese MAP abusers.
|
| キーワード | brain-derived neurotrophic factor
polymorphism
drug abuse
methamphetamine
|
| 備考 | Digital Object Identifer:10.1002/ajmg.b.30097
Published with permission from the copyright holder. This is the author's copy, as published in American Journal of Medical Genetics Part B, Neuropsychiatric Genetics, Jan 2005, Volume 132B, Issue 1, Pages 70-73. Publisher URL:http://dx.doi.org/10.1002/ajmg.b.30097 Direct access to Thomson Web of Science record Copyright © 2004 Wiley-Liss, Inc. All rights reserved. |
| 発行日 | 2005-01-05
|
| 出版物タイトル |
American Journal of Medical Genetics Part B, Neuropsychiatric Genetics
|
| 巻 | 132B巻
|
| 号 | 1号
|
| 出版者 | Wiley-Liss, Inc.
|
| 開始ページ | 70
|
| 終了ページ | 73
|
| ISSN | 1552-4841
|
| NCID | AA11815089
|
| 資料タイプ |
学術雑誌論文
|
| 言語 |
英語
|
| 著作権者 | Wiley-Liss, Inc.
|
| 論文のバージョン | author
|
| 査読 |
有り
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| DOI | |
| PubMed ID | |
| Web of Science KeyUT | |
| Submission Path | biology_general/32
|
