ID | 52019 |
フルテキストURL | |
著者 |
Noda, Yohei
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg
Nishizaki, Kazunori
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg
Kaken ID
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Yoshinobu, Junko
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg
Orita, Yorihisa
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg
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Tsujigiwa, Hidetsugu
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral Pathol & Med
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Yamada, Masao
Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Virol
Kaken ID
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抄録 | Conclusion: Bone marrow-derived cells can be engrafted in the olfactory bulb and a few cells can differentiate into mitral/tufted cells in the olfactory bulb. Objectives: To investigate whether bone marrow-derived cells can be engrafted into the olfactory bulb and differentiate into neurons and glial cells after methimazole administration. Methods: Bone marrow of GFP (green fluorescence protein) mice was transplanted into lethally irradiated recipient mice. Immunostaining was performed to confirm the cell types of bone marrow-derived cells expressing GFP. Results: GFP-positive cells were observed in the olfactory bulb at 2 days after methimazole administration. The number of dendritic GFP-positive cells increased up to 30 days after methimazole administration and then decreased. Double immunostaining for GFP and Iba1 or TBX21 showed that a large population of the GFP-positive cells had characteristics of microglia/macrophages and a few cells had characteristics of mitral/tufted cells.
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キーワード | Transplantation
regeneration
olfaction
mitral cells
microglia
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発行日 | 2013-09
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出版物タイトル |
Acta Oto-laryngologica
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巻 | 133巻
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号 | 9号
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開始ページ | 951
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終了ページ | 956
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ISSN | 0001-6489
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資料タイプ |
学術雑誌論文
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オフィシャル URL | http://dx.doi.org/10.3109/00016489.2013.803153
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関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/51950
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言語 |
英語
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論文のバージョン | author
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査読 |
有り
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DOI | |
Web of Science KeyUT |