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ID 11836
Eprint ID
11836
フルテキストURL
Thumnail K003341.pdf 301 KB
タイトル(別表記)
口腔癌における染色体2q21-37部位の微調欠失マッピング
著者
チェンギス ベイハン 岡山大学
抄録
We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were detected at the locations of microsatellite markers, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S1327 (29%), D2S164 (29%), D2S125 (68%) and D2S140 (32%). Three preferentially deleted regions at 2q21-24, 2q33-35 and 2q37.3 were observed. Several candidate tumor suppressor genes in these regions such as LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5, are located. Further molecular analysis of each gene should be performed to clarify their roles in oral carcinogenesis.
キーワード
Oral cancer
2q
2q21-24
2q33-35
2q37.3
Loss of heterozygosity
ING5
CASP8
備考
http://dx.doi.org/10.1016/j.oraloncology.2006.03.004
発行日
2007-03-23
出版物タイトル
資料タイプ
学位論文
学位授与番号
甲第3341号
学位授与年月日
2007-03-23
学位・専攻分野
博士(学術)
授与大学
岡山大学
オフィシャル URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16857411&dopt=Abstract
言語
Japanese
論文のバージョン
none
査読
不明