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ID 11785
Eprint ID
11785
フルテキストURL
K003330.pdf 87.5 KB
タイトル(別表記)
ヒト初乳由来分泌型IgAはボツリヌスB型16S毒素と結合し,毒素のT84細胞への結合を抑制する
著者
松村 拓大 岡山大学
抄録
Botulinum neurotoxin produced by Clostridium botulinum type B is in the form of a complex of 12S and 16S toxins. Food-borne botulism is caused by these complex toxins which are ingested orally and absorbed from the digestive tract. Here, we show that the human milk SIgA binds to the type B16S toxin. The binding of SIgA to 16S toxin and HA was inhibited by carbohydrates such as galactose, suggesting that the interaction of carbohydrate side chain of the SIgA with the HA of the 16S toxin is important for SIgA-16S complex formation. We also demonstrate that SIgA inhibits the attachment of 16S toxin to intestinal epithelial cells. These data suggest that the interaction of antigen nonspecific SIgA with 16S toxin has a large influence on the absorption of 16S toxin from the intestinal epithelium, and that SIgA may provide insight into developing a therapeutic agent for type B food-borne botulism.
キーワード
Clostridium
Botulinum
Botulism
Hemagglutinin
Neurotoxin
Toxin
Secretory IgA
Immunoglobulin
Galactose
Innate immunity
備考
http://dx.doi.org/10.1016/j.bbrc.2006.11.095
発行日
2007-03-23
出版物タイトル
資料タイプ
学位論文
学位授与番号
甲第3330号
学位授与年月日
2007-03-23
学位・専攻分野
博士(医学)
授与大学
岡山大学
オフィシャル URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17156748&dopt=Abstract
言語
Japanese
論文のバージョン
none
査読
不明