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ID 11718
Eprint ID
11718
フルテキストURL
K003312.pdf 73.9 KB
タイトル(別表記)
胸腺由来ドナーT細胞が慢性GVHDを起こす
著者
佐古田 幸美 岡山大学
抄録
Chronic graft-versus-host disease (GVHD) is the most common cause of poor long-term outcomes after allogeneic bone marrow transplantation (BMT), but the pathophysiology of chronic GVHD still remains poorly understood. We tested the hypothesis that the impaired thymic negative selection of the recipients will permit the emergence of pathogenic T cells that cause chronic GVHD. Lethally irradiated C3H/HeN (H-2k) recipients were reconstituted with T-cell-depleted bone marrow cells from major histocompatibility complex [MHC] class II-deficient (H2-Ab1-/-) B6 (H-2b) mice. These mice developed diseases that showed all of the clinical and histopathological features of human chronic GVHD. Thymectomy prevented chronic GVHD, thus confirming the causal association of the thymus. CD4+ T cells isolated from chronic GVHD mice were primarily donor reactive, and adoptive transfer of CD4+ T cells generated in these mice caused chronic GVHD in C3H/HeN mice in the presence of B6-derived antigen-presenting cells. Our results demonstrate for the first time that T cells that escape from negative thymic selection could cause chronic GVHD after allogeneic BMT. These results also suggest that self-reactivity of donor T cells plays a role in this chronic GVHD, and improvement in the thymic function may have a potential to decrease chronic GVHD.
キーワード
BONE-MARROW-TRANSPLANTATION
MINOR HISTOCOMPATIBILITY ANTIGENS
CONSENSUS DEVELOPMENT PROJECT
WORKING GROUP-REPORT
TERM FOLLOW-UP
SELF-TOLERANCE
CORTICAL EPITHELIUM
HUMAN SCLERODERMA
RANDOMIZED-TRIAL
CLINICAL-TRIALS
備考
http://dx.doi.org/10.1182/blood-2006-08-042853
発行日
2007-03-23
出版物タイトル
資料タイプ
学位論文
学位授与番号
甲第3312号
学位授与年月日
2007-03-23
学位・専攻分野
博士(医学)
授与大学
岡山大学
オフィシャル URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17032915&dopt=Abstract
言語
Japanese
論文のバージョン
none
査読
不明