Acta Medica Okayama1999Vortex structure in anisotropic and quantum-limit superconductorsENNobuhikoHayashiElectronic structure of a single vortex (or vortex core structure) in type-II superconductors is theoretically discussed in the present thesis. Low-lying excited states in the superconductors due to the vortex, i.e., "vortex bound states," are examined in detail on the basis of numerical calculations. Two points are focused on: the effect of superconducting gap anisotropy on a vortex (Chapter 2) and the property of a vortex in quantum-limit situation (Chapter 3). The anisotropy of a superconducting energy gap has substantial effects on the structure of the vortex bound states. The local density of states around a vortex is calculated in a clean superconductor with the gap anisotropy within the framework of the quasiclassical theory of superconductivity. A characteristic structure of the local density of states, observed experimentally in the layered hexagonal superconductor 2H-NbSe(2) by scanning tunneling microscopy (STM), is well reproduced by assuming an anisotropic s-wave gap. The local density of states (or the bound states) around a vortex in superconductors with gap anisotropy is interpreted in terms of quasiparticle trajectories to facilitate an understanding of the rich electronic structure observed in STM experiments. This reveals not only a rich internal electronic structure associated with a vortex core, but also unique ability of the STM spectroscopy. The quantum limit means that the superconducting coherence length is small in the limit, i.e., it is comparable to the atomic length order. Focusing on quantum-limit behavior, fundamental structure of a vortex is studied by self-consistently solving the Bogoliubov-de Gennes equation. The discreteness of the energy levels of the vortex bound states is crucial for the vortex structure in the quantum limit. The following are revealed by the study of the quantum limit. The vortex core radius shrinks monotonically up to an atomic-scale length on
lowering the temperature T, and the shrinkage stops to saturate at a lower T. The pair potential, supercurrent, and local density of states around the vortex exhibit Friedel-like oscillations. The local density of states inside a vortex core generally has particle-hole asymmetry induced by the existence of the vortex itself. Some essential properties of general vortices which are concealed within the conventional non-quantum-limit analysis can be extracted by the quantum-limit analysis. On the basis of the inherent particle-hole asymmetry inside vortex cores, it is discussed in this thesis that electric charging of a vortex core is originated from the Friedel oscillation of the Bogoliubov wave functions around the vortex (Chapter 4) . This mechanism of the vortex core charging is independent of the slope in the normal-state density of states at the Fermi level. The temperature dependence of the vortex core charge is also presented. It is expected that by using STM, information on the vortex core charging is extracted through a relation between the vortex core charge and the vortex bound states.No potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999GROWTH CURVE ANALYSIS AND ITS RECENT IMPLICATIONSENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Galois theory for noncommutative rings and actions of pointed Hopf algebrasENTadashiYanaiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Advanced Chemical Analyses for Nitrogen, Phosphorus and Sulfur Compounds Using Flow-Injection SpectrophotometryENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama19993/4filledバンドを有する擬2次元有機伝導体の低温構造と絶縁相EN本研究では,有機分子BEDT-TTFからなる有機伝導体のうち,バンドが3/4filledであり,2次元的なフェルミ面を持ちながら低温で非金属状態となる物質を含む2タイプの結晶構造に関してX線回折の手法により実験をおこない,電子状態の研究を行った.κ型結晶κ-(BEDT-TTF)(2)Cu[N(CN))(2)]X[X =Cl, Br]では,BEDT-TFF分子の2量体(ダイマー)化によってバンドが分裂し,伝導バンドは実効的に1/2 filledと見なせる.これまで提案されてきた"ダイマーモデル"では,ダイマーを1サイトと考え,ダイマー上のon site Coulomb反発U(eff)が2量体化の程度に左右され,系がMott絶縁体となるか否かはU(eff)と伝導バンドの幅W(u)との比で決定されるとしていたが,構造的な証拠が存在しなかった.X=Cl, Brの水素(h8)体,重水素置換(d8) 体について低温で精密結晶構造解析をおこない,"ダイマーモデル"が系統的に成り立つかを研究した.この結果,結晶構造の温度変化が大きく,低温構造が本質的に重要であることが明らかになった.つまり,低温で反強磁性体となるととが知られているCl塩では構造不安定性が小さく順調に格子が熱収縮し,低温でダイマー性が強くなる.これに対し,低温で金属から超伝導体になるBr塩では,2種類の構造変化が200~220K近辺,80K付近で生じる.前者ではきわめて弱い2c周期の変調構造が陰イオン間の相互作用により形成されるが,層間のカップリングが弱く2次元的な秩序に留まる.BEDT-TTF分子にはほとんど影響がなく電子状態への影響は小さい.しかし,80Kでは陰イオンとBEDT-TTFのフラストレーションにより,BEDT-TTFにも配置の変化が起こりon site Coulomb反発U(eff)の程度に影響を与える.この2種類の変化は独立であり,そのいずれもが,これまでの予想とは異なり,BEDT-TTF終端のエチレン基の配向度とは直接関連していない.今回,低温で得られた原子座標と既存の原子座標とを用いてバンド計算をおこない比較した結果,(1)h8体のBr塩を除き,絶縁体から金属まで,低温構造から見積もられるU(eff)/Wで整理され,ダイマーモデルで理解できること,(2)Cl塩とBr塩とではハロゲン原子の置換が80Kの構造変化の有無をひき起こし, 80K以下で2量体化の程度が大きく拡大しU(eff)に差が生ずること,および,(3)d8-Br塩の急冷状態が絶縁体なのはU(eff)の差ではなく,80Kの構造変化が不完全になりダイマー問の移動積分(つまりはバンド幅)が小さくなるためであることがわかった.h8-Brでは,d8-Brの急冷状態とほぼ同じ傾向が観測された.これは徐冷時には金属(11.6K以下で超伝導)になることと一見矛盾するが,発表されているh8体のBr塩の構造データは,温度因子が低温でも大きく,構造的には急冷相であると考えられるので,実はダイマーモデルでも理解可能である.第2の物質系であるθ-(BEDT-TTF)(2)CsCo(SCN)(4)では,金属状態ではBEDT-TTF分子の2量体化がなく,したがって単一の3/4 filledバンドをもち,フェルミ面も常圧では楕円型に近い単純な形状をしている.アニオン中の金属原子を化学置換したものでは金属ー絶縁体転移温度が系統的に増加する.この化学置換により分子間の2面角が変化する結果バンド幅Wが減少することから,絶縁相がMott相であり,低温では2量体が形成されると予想されていた.たしかにθ-(BEDT-TTF)(2)CsCo(SCN)(4)の低温非金属状態では2倍の超格子構造が形成されることが発見されたが,その振幅,相関長から,ダイマーモデルのMott相としての取り扱いは困難であり,むしろ最近接クーロン反発の効果による電荷秩序相と考えた方よいことがわかった.なお,物理的な圧力を加えると,分子2面角θが増加するときに,化学置換の効果と逆にバンド幅Wは増加する.このように,物理圧効果と化学置換効果とは,体積の減少という点では似ているが本質的には異なることが明らかになった.更に10.7kbarの物理的圧力下では,衛星反射の観測により他に類例のない圧力誘起の2k(F)CDWを発見した.これはバンド幅の増大と擬1次元的なフェルミ面の形成の双方に起因するものとして理解される.No potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999統計モデルにおける局所影響分析ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Group completion for multi H-maps and higher υn torsion in Lie groupsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999On the cohomologies of free loop spaces and rational cyclic cohomologiesENToshihiroYamaguchiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Homotopy field name="type"s and Homotopy classes of Self mapsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999銅イオン交換したhigh-silicaゼオライトの気体吸着特性と銅イオン種の状態ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama19993d遷移金属化合物の電子状態に関するX線分光学的研究EN3d遷移金属(3d-TM)化合物におけるK-吸収端のX線近吸収端構造(XANES)およびX線磁気円二色性(XMCD)を利用して3d-TMの電子状態および磁気状態について調べた.このX線吸収分光法の特長を活かすことによって,3d-TM化合物の多様な磁気的性質を電子状態の観点から考察した.3d-TMイオンおよび配位子を変化させたときの3d-TMおよび酸素のK-吸収端XANESスペクトルの系統的な変化から,吸収端近傍の構造はTMイオンの3d電子状態を強く反映していることを見出した.スピネル型フェライトMFe(2)0(4)(M=Cr~Cu)におけるXMCDの系統的な変化から,サイトによる寄与を分離した.また,金属性Fe化合物のXMCDでは配位子からの電荷移動によるFeの電子配置の変化を議論した.さらに,K-吸収端に対する磁気光学総和則の適用によって,4p軌道磁気モーメントを求め,酸化物と金属性化合物では互いに反対符号を持つことが明らになった.XMCDスペクトル中に観測される多電子励起(MEE)シグナルに対する系統的な変化から,MEEの特徴を捉えることによってその機構の解明を行った.エネルギー位置,強度,幅等の特徴からshake-up過程に付随する3p→4p単極遷移は否定され,終状態が(1s)(1)(3p)(5)(3d)(n+2)で表されるsuper Coster-Kronig遷移であることを提案し,実験的にそれを立証した.X線吸収分光法を利用して電子状態を議論するためには,エネルギ一分解能および統計精度の点で第三世代放射光の利用が適している.そこでSPring-8 BL39XUにおいて透過型移相子とピエゾ素子およびロックイン検出法の組み合わせによる「偏光変調法」XMCD測定を確立した.エネルギー分解能および統計精度に格段の向上が得られ, XMCDスペクトルに新たな微細構造が観測された.これによって,電子状態や磁気状態の詳細を議論することが可能となる.No potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999An oxygen isotopic study of meteorites: Implications of the early solar system processesENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Genesis of eclogites associated with peridotites in the Bohemian MassifENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999自然太陽光及び紫外線によって誘発される突然変異に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999金属ポルフィリン固定化担体のペルオキシダーゼ様機能のフローインジェクション分析法への応用ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999ラットの膵炎モデルに対するMethylcarbonylmethyl 2(S)- [4-(4-guanidino-benzoyloxy) phenyl] propionate methanesulfonate (TT-S24)の薬理学的研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999ラットの学習記憶に及ぼすヒスタミン神経系の役割ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama19994-(N,N-Dimethylaminomethyleneamino) pyrimidine誘導体とhydroxylamineとの反応ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999ペプチド性医薬品の消化管吸収性の評価と予測ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999D-乳酸を生じるMG bypassの生化学的意義について 軟体動物及び鳥類を用いたD-乳酸の生成機構に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999新規ジヒドロピリジン誘導体塩酸ワタニジピンの薬理学的特性およびその作用メカニズムの研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999高分子ゲル小球体による消化管内移行速度制御と薬物の吸収特性改善ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999新規HPLC用充填剤としてのニッケルフタロシアニン固定化シリカゲルとその応用ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999喘息治療を目的としたインドリルピペリジン骨格を有する抗アレルギー薬の合成研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999DNA診断法を用いて見出された卵形マラリア原虫変異体の18SrRNA遺伝子の解析ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Structure-Function Analyses of Bacterial Na+-coupled TransportersENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999労働刑法の現代的展開ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999『源氏物語』における物の怪についての研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999高橋虫麻呂研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Studies on the survey of novel nitrile hydratase producing microorganisms and their application for the synthesis of useful amideENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999褐毛和種の軟骨異形成性矮小体躯症に関する分子遺伝学的研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Mechanisms of Aluminum-Induced Iron Chlorosis in Wheat (Triticum aestivum )ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999タバコ培養細胞におけるアルミニウムに対する応答反応の解析ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999キュウリの形状認識に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999STUDIES ON OXYTOCIN RECEPTORS IN BOVINE GRANULOSA CELLSENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999タバコ培養細胞におけるアルミニウム障害ならびに防御機構に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999家畜糞尿リサイクルの課題と対策 牛糞堆肥を中心としてENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999ムギ類の深播耐性に関する遺伝・育種学的研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999扁平上皮癌細胞株におけるテロメラーゼ活性に対するCisplatinの影響に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Porphyromonas gingivalisの2つの特異的外膜蛋白遺伝子の性状とそれら遺伝子を用いた歯周ポケットにおける感染分布の研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999スケーラーによる歯垢除去及びブラッシングのイヌ歯周組織における病理組織学的研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999口腔前癌病変および扁平上皮癌におけるApoptosisと関連抗原に関する検討ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Radiographic and morphologic studies of multiple miliary osteomas of cadaver skinENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999培養軟骨細胞を用いた周期的メカニカルストレスによる軟骨破壊機序に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999象牙質と接着性レジンセメントの接着における仮着材の影響ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999扁平上皮癌細胞株におけるシスプラチン耐性機構へのメタロチオネインの関与についてENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999マウス歯胚基底膜におけるⅣ型コラーゲンα鎖の消長に関する免疫組織学的研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Capnocytophaga granulosaの産生するアミノペプチダーゼの精製とその性質ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999末梢型ベンゾジアゼピン受容体とミダゾラムの臨床効果との関係についてENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999cAMPによる好中球走化能抑制機序に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999軟骨由来の成長因子Hcs 24/CTGFの特異的受容体を介する軟骨細胞増殖・分化促進作用ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999口腔癌患者の唾液中に見いだしたペプチド,デフェンシンに関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999非復位性関節円板前方転位症例における各種初期治療の有効性 Randomized Controlled Trialによる解析ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999ヘルパーT細胞の産生するサイトカインがPorphyromonas gingivalis由来53KDa外膜蛋白に対する体液性免疫応答に及ぼす影響ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Long-term evaluation of early versus late orthodontic treatment of crowded first premolar extraction casesENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999歯根膜線維芽細胞が特徴的に発現する遺伝子に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999小児歯科における行動科学 精神発達と鼻部皮膚表面温度変化様式との関連性ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999齲細菌叢の分析への分子系統学的手法の応用ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999アクリルコアシェルポリマーによるコンポジット型接着性レジンセメントの改良ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999rhBMP-2/コラーゲン複合体によるラット頭部骨膜下骨増生に関する病理組織学的研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999骨芽細胞様細胞株MC3T3-E1のメカニカルストレスに対する応答性 神経栄養因子の役割ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999IN VITRO STUDY ON THE BARK EXTRACT OF AZADIRACHTA INDICA (NEEM) CHEWING STICK: ITS EFFECTS ON THE GROWTH,ACID PRODUCTION AND ADHERENCE OF STREPTOCOCCUS SOBRINUSENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999魚鱗からの水酸アパタイトの分離誘導と重金属イオン除去への応用ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999非水リチウム電池正極活物質用マンガン酸化物に関する界面電気化学的研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999熱媒体の沸騰・凝縮現象を利用した形状安定化処理ポリエチレン粒子充填潜熱蓄熱システムに関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Studies on Scheduling Problems under Fuzzy EnvironmentENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Study on Human Pancreatic-field name="type" Ribonucleases and Application to the Development of Humanized ImmunotoxinENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999ヒューマンインターフェースのための身体動作の画像処理手法に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999超電導エネルギー貯蔵装置を用いた電力変動平滑化制御に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Bioactivity of inorganic-organic composite materials incorporating calcium ions and silanol groupsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999声道モデルとその音響伝達特性に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999AHPにおける一対比較法の提案および応用に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Fundamental Study on the Decomposition Mechanism of Polymers over Solid Acid CatalystENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999CAD図形情報と画像処理を組み合わせた対象物の認識手法に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Studies on the Generation of IminiumIon and Its Application to Organic SynthesesENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999電気音響変換器の設計と特性評価に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Study on Numerical Techniques for Magnetic Recording Analysis Using Micromagnetic ModelENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999A Rearrangement Route to the Synthesis of Fluorinated Amino AcidsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Kinetic Studies on Thermolysin-Catalyzed Synthesis of Dipeptide Precursors with Immobilized and Free Enzymes in Organic SolventsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Bi系銅酸化物超伝導体への元素添加と特性改善に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999放電加工用グラファイト電極の高性能化に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999ギャップのリラクタンス変化を利用した回転位置センサおよび電動機とその制御に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Research on the Application of Distributed Instrinsic Fibre Optic Temperature Sensing for Geotechnical EngineeringENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999気体燃料を含む雰囲気における軽油噴霧の着火遅れに関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Illegal Immigration and Economic WelfareENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama19991975~85年の日本銀行金融政策の実像 いわゆる「マネーサプライ重視政策」の検証ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Novel Peptide Nucleic Acid with Polyetheramide Main ChainENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999安岡章太郎の文学と思想ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999植物防御応答遺伝子の発現調節機構の解明に関する研究EN高等植物は病原菌の攻撃に対して種々の防御応答遺伝子の発現を誘導する。本研究では、病原菌由来シグナル物質に応答した植物防御応答遺伝子の発現調節機構の解明に向けて、エンドウとエンドウ褐紋病菌の系をモデルとして解析を行った。エンドウ褐紋病菌は、その胞子発芽液中に、エンドウの防御応答を誘導する物質(エリシター)と、防御応答を一時的に抑制する物質(サプレッサー)を分泌する。エンドウ組織にエリシターを処理するとファイトアレキシン合成に関与するフェニルアラニン・アンモニアリアーゼ(PAL) およびカルコン合成酵素(CHS) をコードする遺伝子の転写が5分以内に活性化されるが、一方、サプレッサーを処理するとこれらの遺伝子の転写は速やかに抑制されることが確認されている。このことは、細胞表層においてエリシターあるいはサプレッサーが認識された後、そのシグナルが速やかに核に伝達され、PALやCHSなどの防御応答遺伝子の転写調節が行われることを示している。エリシター応答性を示すエンドウCHS遺伝子の一つ、PSCHS1遺伝子についてエリシターおよびサプレッサー応答性シスエレメントの解析をトランジェントアッセイにより行ったところ、1)エリシタ一応答性を示すエンドウPAL・CHS遺伝子プロモーター上に保存されている塩基配列モチーフ、BoxI、BoxIIおよびG-boxが本遺伝子のエリシター応答性遺伝子発現において重要な役割を果たしていること、2) PSCHS1遺伝子プロモーターの-242~+78の領域がサプレッサー応答に関与する可能性が示唆された。次に、in vlvoフットプリント解析により、in vivoにおいてこれらの配列モチーフへの核タンパク質(転写調節因子)の結合がエリシターやサプレッサーによりどのように制御されているのかを解析した。エリシタ一応答性を示すPSPAL1,2およびPSCHS1,2遺伝子プロモーターについて調べたところ、3) エリシター処理により、これら4種のプロモーター上に共通して存在するBoxI配列部分に核タンパク質の結合が誘導されること、4) PSCHS1,2に関しては、これらのプロモーター上に共通して存在するAGCCリピート配列部分にも核タンパク質の結合が誘導されること、5) PSCHS1では、トランジェントアッセイによりその重要性が示唆されていたG-box配列部分にも核タンパク質の結合が誘導されること、6) 一方、サプレッサーを処理すると、これらエリシター処理により誘導される核タンパク質の結合が部分的に阻害されることが判明した。近年、当研究室において、エリシター処理により発現が誘導される遺伝子cDNAを多数単離し構造解析を行ったところ、その中の一つ、E84遺伝子がDofドメインと呼ばれるDNA結合ドメインを有する推定の転写制御因子をコードしうることが判明した。E84遺伝子の発現パターンをノーザンハイブリダイゼーション法により解析したところ、本遺伝子の発現は傷ストレスおよびエリシター処理により誘導されるが、サプレッサー存在下では発現誘導が顕著に抑制されることが判明した。E84タンパク質の機能を明らかにする足掛りとして、ランダムバインディングサイトセレクション解析により結合DNA塩基配列の同定を行ったところ、E84タンパク質はGAAAGあるいはGAAAAGをコアとする塩基配列に結合することが判明した。エリシター応答性を示すエンドウPAL・CHS遺伝子プロモーター上にGAAA(A)G配列が存在するかを調べたところ、いずれも転写開始点付近に共通して存在していた。次に、E84タンパク質がPSCHS1プロモーターに結合しうるかをゲルシフトアッセイにより調べたところ、GAAAG配列を複数個含む領域(-44~+36)に強く結合しうること、さらに、PSCHS1プロモーターから本領域を除去するとエリシター応答性が有意に低下した。以上の結果から、E84タンパク質がエンドウPAL・CHSをはじめとする防御応答遺伝子(群)の転写を正に制御する転写調節因子として機能している可能性が示唆された。No potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999新漸進的弛緩法の改良を中心とする心理生理学的研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999省人化工場内の作業者の安全確保のための画像処理によるモニタリング手法に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Purification and characteristics of novel antibacterial substance from lactic acid bacteriaENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999STUDIES ON IN VITRO MATURATION OF BOVINE OOCYTES AS AFFECTED BY FOLLICULAR CELLS AND EPIDERMAL GROWTH FACTORENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Studies on Inheritance of Male Sterility and in vitro Culture of Anther and Pollen in Radiation-Induced Male Sterile Mutants of TomatoENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999植物のアポトーシスに関する基礎的研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999中国における政府間財政関係の展開ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999近世史料の整理法とその利用形態の研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999STUDIES ON PARTICIPATION OF SUGAR RESIDUES OF ZONA PELLUCIDA AND SPERM GLYCOSIDASES IN IN-VITRO SPERM-OOCYTE INTERACTION IN PIGSENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999イギリス社会福祉における政府間行財政関係の研究 1960年代以降を中心としてENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999ヌートリアのタンパク質栄養における食糞の意義と軟糞生成機構ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999STUDIES ON THE DEVELOPMENTAL BLOCK INDUCED BY PHOSPHATE IN 1-CELL RAT EMBRYOS CULTURED IN A CHEMICALLY DEFINED MEDIUMENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999わが国近代漁業の地域的展開ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999日本の経済発展と産業教育中国の職業教育との比較ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Development of precise isotope analysis of uranium and thorium for the study of uranium-thorium disequilibrium in the magma processesENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Development of Image Processing Algorithms for Weed Detection in Lawn FieldENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Agronomic and Morphological Differences of Determinate and Indeterminate SoybeansENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Mineralogical and Geochemical Studies of the Ashanti Gold Deposit at Obuasi,GhanaENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999The effects of wild cruciferous host plants on the biological traits and flight activity of the diamondback moth,Plutella xylostella (Lepidoptera: Yponomeutidae)ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999POSSIBILITY OF WINGED BEAN (Psophocarpus tetragonolobus) AS NEW FEED RESOURCES FOR POULTRYENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Flow through a Rotating Curved DuctENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Improved HPLC determination of acidic opines by phenylisothiocyanate derivatization and its application to marine animals.ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999“A Spatio-Drainage Approach"A Contribution to Land Drainage TheoryENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Effective utilization of solar energy in agricultureENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Geochemical and isotopic study of pyroxene granulites of Swat, Chilas Complex, Kohistan Island Arc, Northen PakistanENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999iaaM遺伝子導入によるネオティフォディウムエンドファイトの形質転換ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Ratio of CD44 Epithelial Variant to CD44 Hematopoietic Variant is a Useful Prognostic Indicator in Gastric and Colorectal CarcinomaENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999第1編RENAL AT1 RECEPTOR:AUTORADIOGRAPHIC LOCALIZATION AND QUANTIFICATION IN RAT 第2編 RENAL AT1 RECEPTOR:COMPUTERIZED QUANTIFICATION IN SPONTANEOUSLY HYPERTENSIVE RATS AND DOCA- SALT RATSENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Perineuronal Sulfated Proteoglycans in the Adult Rat Brain:Histochemical and Electron Microscopic StudiesENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Perineuronal Sulfated Proteoglycans,Cell Surface Glycoproteins and Dark Neurons in the Cingulate Cortex of Newborn and Adult RatsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Effects of myosin isozyme shift on curvilinearity of the left ventricular on curvilinearity of the left ventricular of in situ rat heartsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999RESISTANCE TO NITRIC OXIDE-MEDIATED APOPTOSIS IN HL-60 VARIANT CELLS IS ASSOCIATED WITH INCREASED ACTIVITIES OF Cu,Zn-SUPEROXIDE DISMUTASE AND CATALASEENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Appearance and distribution of two Ca2+-binding proteins during development of the cochlea in the musk shrewENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Determination of Glutathione Peroxidase Activity and its Contribution to Hydrogen Peroxide Removal in ErythrocytesENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Typology of Abdominal Arteries,with Special Reference to Inferior Phrenic Arteries and their Esophageal BranchesENDa XunPiaoOrigins and distribution of the human inferior phrenic arteries were studied by dissecting 68 Japanese adult cadavers. The inferior phrenic arteries were usually observed as paired (left and right) vessels. Their origins were summarized as follows: a) the aorta itself (85/138 cases, 61.6%), b) the ventro-visceral arteries (celiaco-mesenteric system of the aorta) including the celiac trunk (39/138 cases, 28.2%) and the left gastric artery (4/138 cases, 2.9%), and c) the latero-visceral arteries (adreno-renal system of the aorta) including the middle adrenal artery (4/138 cases, 2.9%) and the renal artery (6/138 cases, 4.3%). The left and right arteries occasionally originated in common trunk from the aorta, celiaco-mesenteric system or adreno-renal system (22/138 cases, 15.9%). A typological diagram explaining these variations is given. The inferior phrenic arteries, especially the left ones, sometimes issued visceral or esophageal branches. This fact indicates that the inferior phrenic arteries are homologous with the celiac trunk and mesenteric arteries. It is further discussed that the celiac trunk and mesenteric arteries are originally paired vessels, through introduction of our previous typological diagram of the abdominal arteries.No potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999IgA 腎症に対する口蓋扁桃摘出術の治療効果と長期予後予測因子ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Suitable Image Parameters and Analytical Method for Quantitatively Measuring Cerebral Blood Flow Volume with Phase-Contrast Magnetic Resonance ImagingENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Transplanted and repopulated retinal pigment epithelial cells on damaged Bruch's membrane in rabbitsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Quantitative analysis of interleukin 6(IL-6) in patient with IgA nephropathy after tonsillectomyENNo potential conflict of interest relevant to this article was reported.Acta Medica OkayamaSex differences in oxidative damage in ddY mouse kidney treated with a renal carcinogen, iron nitrilotriacetateENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Progressive patterns of degenerative arthritis in scaphoid nonunion demonstrated by three- dimensional computed tomographyENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Effect of dose intensity of methotrexate,doxorubicin,and ifosfamide on the prognosis of patients with osteosarcomaENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Angiography for Assessment of Preoperative Chemotherapy in Musculoskeletal SarcomasENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Effects of Intracoronary Caffeine on Left Ventricular Mechanoenergetics in Ca2+ Overload Failing Rat HeartsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Antitumor Effect of Diphtheria Toxin A-Chain Gene-containing Cationic Liposomes Conjugated with Monoclonal Antibody Directed to Tumor-associated Antigen of Bovine Leukemia CellsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Rat Parathyroid Gland,with Special Reference to Its Blood Vascular Bed,Pericapillary Space and Intercellular SpaceENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999The Alteration of Penicillin-Binding Proteins (PBPs)in drug-resistant Streptococcus pneumoniae isolated from acute otitis mediaENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999The Expression of Vascular Endothelial Growth Factor and Transforming Growth Factor-β Associates With Angiogenesis in Epithelial Ovarian CancerENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Relationship between parameters of the urea kinetic model and those of nutritional status in patients on hemodialysis 第1編 Relationship between parameters of the urea kinetic model serum amino acid levels in patients on hemodialysis 第2編 Serum Leptin Concentrations in Patients on HemodialysisENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Effects of lamotrigine and conventional antiepileptic drugs on amygdala- and hippocampal-kindled seizures in ratsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Isolation of MHC class I restricted tumor antigen peptide and its precursors associated with heat shock proteins-hsp70,hsp90 and gp96ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Human Papillomavirus as a Risk Factor for Head and Neck Cancers-A Case Control StudyENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Enhanced Fos expression in rat lumbar spinal cord cultured with cerebrospinal fluid from patients with amyotrophic lateral sclerosisENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Bone status assessment in preterm and term infants by dual-energy X-ray absorptiometryENRintaroMoriNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999A 15N GC/MS Study of In Vivo Glutamine Synthesis in Liver Failure RatsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Seroepidemiologic Studies of Hepatitis C Virus Infection in a Population of Okayama Prefecture Screened for Liver DiseaseENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Establishment of a Drug-Sensitivity Panel Using Human Lung Cancer Cell LinesENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Evaluation of the effect of preoperative chemotherapy in bone sarcomas 99mTc-HMDP scintigraphy in 34 casesENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Effects of Experimental Chemoendocrine Therapy With a Combination of a Pure Antiestrogen and 5-Fluorouracil on Human Breast Cancer Cells Implanted in Nude MiceENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease Ⅲ with those of the adjacent parts of TSC'2 and SLC9A3R'2 genesENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Increased Type '2 Cytokine Expression by Both CD4+CD45RO+T Cells and CD8+CD45RO+T Cells in Blood Circulation is Associated with High Serum IgE but not with Atopic DermatitisENAtsushiSatoType 2 cytokines, such as interleukin-4 (IL-4) and IL-13, are associated with immunoglobulin E (IgE) production. This association has also been observed in CD8+ T cells from patients infected with leprosy and human immunodeficiency virus (HIV). Using intracellular cytokine staining and flow cytometry, the cytokine profile [IL-2, IL-4, IL-10, IL-13, and interferon (IFN)-gamma] of both CD4+ and CD8+ memory/effector T cells circulating in atopic dermatitis (AD) patients was investigated at the single cell level. The levels of type 2 cytokines in CD4+ T cells or CD8+ T cells in AD patients with high levels of serum IgE (AD-H), low levels of serum IgE (AD-L), and healthy controls were compared. Increased production of IL-4 and IL-13 in both CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells after 4 h in vitro stimulation with phorbol 12-myristate 13-acetate and ionomycin, was more prominent in AD-H patients than in AD-L patients or healthy controls, whereas IFN-gamma-producing CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells were relatively diminished in AD-H patients. CD4+ T cells and CD8 + T cells from AD-H patients, cultured for 48 h with phorbol 12-myristate 13-acetate and ionomycin, released larger amounts of IL-4 and IL-13 but smaller amounts of IFN-gamma than both types of cells from AD-L patients or healthy controls. In addition, when stimulated with immobilized anti-CD3 monoclonal antibody (MoAb) and anti-CD28 MoAb, CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells from AD-H patients contained more IL-4-producing cells but fewer IFN-gamma-producing cells compared with healthy controls. Finally, spontaneous mRNA expression of IL-4 in blood CD8+ CD45RO+ T cells isolated from AD-H patients was increased, as determined by reverse transcriptase-polymerase chain reaction. Therefore, in AD patients with high IgE levels, type 2 cytokine (IL-4 and IL-13) expression is associated with IgE production, in both CD4+ CD45RO+ T cell and CD8+ CD45RO+ T cell subsets.No potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Experimentalβ-Alaninuria Induced by (Aminooxy)acetateENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Increase of Cytochrome c Oxidase Negative Fibers in Rimmed Vacuole Myopathy with Inflammatory ChangesENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999HYPERAMMONEMIA INDUCED BY ADMINISTRATION OF GLUCOSE AND INSULIN AFTER HEPATOPANCREATECTOMY IN RATENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Effect of continuous infusion of vasopressin on glomerular growth response in spontaneously hypertensive ratsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Treatment with a Ca2+ Channel Blocker, Barnidipine,Reduces Platelet-Derived Growth Factor B-Chain mRNA in Glomeruli of Spontaneously Hypertensive RatsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Accumulation of Nз-(Carboxy-methyl)lysine and Changes in Glomerular Extracellular Matrix Components in Otsuka Long-Evans Tokushima Fatty Rat: A Model of Spontaneous NIDDMENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Hearing Immaturity Found by ABR and its Clinical Impact on Otoneurological EvaluationENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Volume Quantification of Healthy Paranasal Cavity by Three-Dimensional CT ImagingENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Calbindin and Calmodulin Localization in the Developing Vestibular Organ of the Musk Shrew (Suncus murinus)ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999CHARACTERISTICS AND VARIABILITY OF VERTICAL PHORIA ADAPTATION IN NORMAL ADULTSENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Formation of γ-Glutamylpropargylglycylglycine from Propargylglycine in Human Blood and ErythrocytesENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Nursing Practitioners' Perception of Inpatients' Anxiety,Self-Esteem, Purpose-in- Life and Health Locus of controlENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Improvement of Sensitivity in HLA-DRB1 Typing by Semi-nested PCR-RFLPENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Left ventricular volumetric conductance catheter for ratsENHaruoItoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Factors Affecting the Rectus Femoris- Patellar Tendon Q-Angle Using A Computed Tomographic ScanENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999High-performance liquid chromatographic determination of β-alanine,β-aminoisobutyric acid and γ-aminobutyric acid in tissue extracts and urine of normal and (aminooxy) acetate-treated ratsENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Expression of the bcl-'2 part name="family" in the course of keratinocyte differentiationENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Association of Fatty Liver with Increased Ratio of Visceral to Subcutaneous Adipose Tissue in Obese MenENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1999Analysis of circulating hematopoietic progenitor cells after peripheral blood stem cell transplantationENNo potential conflict of interest relevant to this article was reported.