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kn-title=Methemoglobin Formation by Potassium Ferrocyanide in the Hemolysate of Acatalasemic Mice
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kn-title=レーザー虹彩切開術後の虹彩神経に関する研究 第1報 ノルアドレナリン作動性神経の変化 第2報 Substance P 陽性神経の変化
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kn-title=脾臓および末梢血単核細胞より誘導したヒト Lymphokine-activated killer (LAK) 細胞におけるパーフｫリンの発現に関する研究
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en-title=高速液体クロマトグラフｨー(HPLC)による血清,羊水中の estetrol, estriol, cortisone, cortisol の全自動化直接測定法
kn-title=Automated direct high-performance liquid chromatographic assay for estetrol, estriol, cortisone and cortisol in serum and amniotic fluid
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en-title=鉄ニトリロ三酢酸投与後ラット血清におけるラジカル促進性"自由"鉄濃度の検討:他の鉄キレート化合物との比較
kn-title=Radical-Promoting "Free" Iron Level in the Serum of Rats Treated with Ferric Nitrilotriacetate : Comparison with Other Iron Chelate Complexes
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en-title=ラット鼻咽腔リンパ組織の血管構築
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kn-subject=
en-title=キンドリング発達に及ぼすα-ジフルオロメチルオルニチンとプトレッシンの扁桃核内投与の効果
kn-title=Effects of intraamygdaloid injections of α -difluoromethylornithine and putrescine on the development of electrical kindling in rats
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=林泰資
kn-aut-sei=林
kn-aut-mei=泰資
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
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dt-received=
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dt-accepted=
dt-pub-year=1991
dt-pub=19910930
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kn-subject=
en-title=ブタ同所性肝移植における温阻血障害に対する,新しい徐放性スーパーオキサイドジスムターゼの効果
kn-title=A New Slow Delivery Type of Superoxide Dismutase Prevents Warm Ischemia Damage in Swine Orthotopic Liver Transplantation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=蓮岡英明
kn-aut-sei=蓮岡
kn-aut-mei=英明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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dt-pub-year=1991
dt-pub=19910930
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kn-subject=
en-title=
kn-title=排水中の有機基質,窒素および燐の同時除去プロセスの開発とその特性に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岸本民也
kn-aut-sei=岸本
kn-aut-mei=民也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
no-vol=
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dt-received=
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dt-pub-year=1991
dt-pub=19910930
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kn-article=
en-subject=
kn-subject=
en-title=
kn-title=生体触媒を用いた不斉還元反応における立体制御に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=宮井武彦
kn-aut-sei=宮井
kn-aut-mei=武彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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dt-received=
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dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=混和材料によるコンクリートの品質改善に関する工学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小川鑑
kn-aut-sei=小川
kn-aut-mei=鑑
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
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dt-received=
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dt-pub-year=1991
dt-pub=19910930
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en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=人工皮革製造に関する装置工学的ならびに管理工学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=藤原恒昭
kn-aut-sei=藤原
kn-aut-mei=恒昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
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end-page=
dt-received=
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dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=NATMにおける岩盤評価の合理化に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=鈴木昌次
kn-aut-sei=鈴木
kn-aut-mei=昌次
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
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article-no=
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end-page=
dt-received=
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dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=歯肉縁上歯石に関連するペプチダーゼ産出菌の同定について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=森田学
kn-aut-sei=森田
kn-aut-mei=学
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=矯正治療中の咬合の変化が咀嚼筋活動に及ぼす影響に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=土屋公行
kn-aut-sei=土屋
kn-aut-mei=公行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=青果物によるエチレン生成の誘導機作に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=高俊平
kn-aut-sei=高
kn-aut-mei=俊平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=密植･根域制限栽培による4倍体ブドウの早期成園化の実証
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=今井俊治
kn-aut-sei=今井
kn-aut-mei=俊治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on culture and application of embryonic stem cells in the mouse
kn-title=マウス胚性幹細胞の培養とその応用に関する発生工学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Embryonic stem (ES) cells isolated from mouse preimplantation embryos can be maintained as a pluripotent cell line in culture. Since ES cells are capable of contributing to a wide variety tissues including the germ line, when they are injected into host embryos, they are considered to be the useful tool for the production of transgenic mice. However, these abilities of ES cells tend to lose during cul ture in long term, or in the process in transfection with foreign gene and selection process. The purposes of the present study is 1) to isolate new ES cell lines, 2) to examine the culture conditions for maintenance of them, 3) to develop efficient method for production of viable germ line chimaeras and 4) to demonstrate the production of transgenic mice. I. Studies on the isolation of embryonic stem cell lines from mouse blastocysts and inner cell masses in the mouse The mouse blastocysts or inner cell masses (ICMs)isolated were cultured on feeder cell layer of the primary embryonal fibroblast cells inactivated with mitomycin C treatment. Totally, 11 ES cell lines were isolated from 2l0 blastocysts or ICMs obtained from sevral different mouse strains. There was no difference in the efficiency of the ES cell line isolation among the mouse strains and between blastocysts and ICMs. Colonies of these cells showed formed EC cell like morphology forming compact islands of cells wi th unclear cell borders. Three of ES cell lines, TT-12,  TT-B4 and F1/1,  had diploid chromosomes with the proportions of 78%, 78% and 72% respectively. In order to determine the differentiation potential of the ES cells in vitro TT-12 and F1/1 cells were cultured in suspentlon without feeder cell layer. They differentiated spontaneously into the cystic embryoid bodies which contained variety of tissues including endoderm and ectoderm like cells, indicating pluripotency of the cells in vitro. II. Studies on the culture conditions to maintain embryonic stem cells. The proligeration activity and undifferentiation conditon of F1/1 cells, which were isolated from a blastocyst obtained from C57BL/6 female mated with CBA male, were examined when they were cultured with different feeder cell layers or with Leukemia inhibitory factor (LIF). The proportions od colony formation and colonies with positive for alkaline phosphatase were higher when F1/1 cells were cultured for 3 to 7 days with primary embryonal fibroblast cells than with the STO cells. These feeder cell layers are indispensable to inhibit the differentiation of F1/1 cells during culture. When F1/1 cells were cultured through 15 passages with LIF without feeder cell layer, they were maintained undifferentiated and 68% of them had normal karyotype (38+XY). However, no young were obtained when chimaeric embryos produced between 8 cell embryos and F1/1 cells maintained with LIF were trasferred to the recipients, while 50 to 88% of young obtained from chimaeric embyos with F1/1 cells maintained in culture with feeder cells were chimaeras. Although many ES cell lines have been isolated from several mouse strains, the cell lines to produce germ line chimaeras have been limited to the l29 strain origin. The present study demonstrated that F1/1 cells isolated from a blastocyst having the C57BL/6xCBA genotype could produce germ line chimaeras by injecting the cells into blastocysts and 8-cell embryos. The chimaera production rate using CD-1 blastocysts as the host was wery low (20%) as reported by other investigaters. However,  when F1/1 cells were introduced into the perivitteline space of 8-cell embryos obtained from CD-1 strain mice, very high proportion (80%) of chimaeric mice be produced and the chimaeric mice showed extremely high chimaerism. In the breeding tests, germ line chimaeras were indicated in 89% of fertile male and most of them had spermatozoa derived only from F1/1 cells. No live youg were obtained when chimaeric eggs,  which were produced by injecting F1/1 cells into parthenogenetic 8-cell eggs,  were transferred. IV. Studies on the production of transgenic mice using ES cells F1/1 cells transformed with the neomycin phosphotransferase (neo) gene using electroporation methods were selected for G4l8 resistance and tested for its ability to produce chimaeric mice. Two types of wave forms, square wave and exponential decay, were used for electroporation. There was no difference between square wave and exponential decay in the efficiency of transformation of F1/1 cells. Southern blot hybridization analysis demonstrated that four of neomycin resistant ES cell lines had neo gene sequences in their genomic DNA but another two cell lines lacked it. The karyotype of them appeared to be stable, as it had still euploid chromosome constitution after transformation and the selection. Two of the lines contained significant populations of the cells with chromosomal abnomality. Overt coat color chimaeras were obtained and their germ lines were transmitted with all four neo resistant ES cell lines tested. Southern blot hybridization and PCR analysis of genomic DNA confirmed again that F(1) and F(2) generation of these germ line chimaeras were transmitted with neo gene stably. These results indicate that ES cells (F1/1) isolated from blastocyst of C57BL/6 female mated wi th a CBA male can be used as a vehicle for transgenesis.
en-copyright=
kn-copyright=

en-aut-name=TokunagaTomoyuki
en-aut-sei=Tokunaga
en-aut-mei=Tomoyuki
kn-aut-name=徳永智之
kn-aut-sei=徳永
kn-aut-mei=智之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=抗腫瘍性トロポロン誘導体の創製と作用機序に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=安藤潤子
kn-aut-sei=安藤
kn-aut-mei=潤子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=慢性関節リウマチ患者関節内におけるInterleukin-1の遊離および各種抗リウマチ薬によるその抑制
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡本全泰
kn-aut-sei=岡本
kn-aut-mei=全泰
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
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cd-vols=
no-issue=
article-no=
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end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
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kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Rebamipide [(±)-2-(4-chlorobenzoylamino)-3-[2-(1H)-quinolinon-4-y1] propionic acid] の抗潰瘍作用に関する薬理学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=山崎勝也
kn-aut-sei=山崎
kn-aut-mei=勝也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=細胞内小核形成による医薬品の遺伝毒性の検出―試験法の確立と小核形成機構の研究―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=若田明裕
kn-aut-sei=若田
kn-aut-mei=明裕
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=イトマキヒトデ (Asterina pectinifera) の生殖細胞に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=三浦智恵美
kn-aut-sei=三浦
kn-aut-mei=智恵美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=コオロギ内部生殖器官の神経生物学的研究
kn-title=Neurobiological Study of the Reproductive Organs in Crickets (Gryllus bimaculatus)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YasuyamaKouji
en-aut-sei=Yasuyama
en-aut-mei=Kouji
kn-aut-name=泰山浩司
kn-aut-sei=泰山
kn-aut-mei=浩司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=完全及び欠陥バクテリオフｧージの逆位DNAセグメント上に存在する遺伝子の構造と機能解析
kn-title=Structural and functional alanalyses of the genes on the invertible DNA segments in intact and defective bacteriophages
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=冨永晃
kn-aut-sei=冨永
kn-aut-mei=晃
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19910930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=リンをドープしたn型シリコン中に化学エッチングによって導入される欠陥
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=米田稔
kn-aut-sei=米田
kn-aut-mei=稔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END