JaLCDOI 10.18926/AMO/56645
フルテキストURL 73_2_101.pdf
著者 Iida, Atsuyoshi| Naito, Hiromichi| Yorifuji, Takashi| Zamami, Yoshito| Yamada, Akane| Koga, Tadashi| Imai, Toru| Sendo, Toshiaki| Nakao, Atsunori| Ichiba, Shingo|
抄録 Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubing. Membrane oxygenator use tended to increase MDZ loss, whereas heparin circuit coating had no influence on MDZ absorption. Similar results were obtained when a second dose of MDZ was injected to the second-use circuits.
キーワード sedatives ECMO polyvinyl chloride pharmacokinetics pharmacodynamics
Amo Type Original Article
発行日 2019-04
出版物タイトル Acta Medica Okayama
73巻
2号
出版者 Okayama University Medical School
開始ページ 101
終了ページ 107
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31015744
フルテキストURL J_Pharm_Sci_130_1_24.pdf
著者 Tangsucharit, Panot| Takatori, Shingo| Zamami, Yoshito| Goda, Mitsuhiro| Pakdeechote, Poungrat| Kawasaki, Hiromu| Takayama, Fusako|
キーワード Acetylcholine-induced vasodilatation CGRPergic nerves Muscarinic receptor subtypes Rat mesenteric arteries
発行日 2016-01
出版物タイトル Journal of Pharmacological Sciences
130巻
1号
出版者 Japanese Pharmacological Society
開始ページ 24
終了ページ 32
ISSN 1347-8613
NCID AA11806667
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 26825997
DOI 10.1016/j.jphs.2015.12.005
Web of Science KeyUT 000369700500004
関連URL https://doi.org/10.1016/j.jphs.2015.12.005