JaLCDOI 10.18926/AMO/31611
フルテキストURL fulltext.pdf
著者 Zhao, Dan Dan| Namba, Taketoshi| Araki, Junichi| Ishioka, Kazunari| Takaki, Miyako| Suga, Hiroyuki|
抄録 <p>Nipradilol (3,4-dihydro-8-(2-hydroxy-3-isopropylamino) propoxy-3-nitroxy-2H-1-benzopyran) is a newly synthesized chemical agent designed to possess beta-adrenoceptor blocking and vasodilating actions. Nipradilol decreased left ventricular contractility index (Emax, slope of the ventricular end-systolic pressure-volume relation), systolic pressure-volume area (PVA, a measure of ventricular total mechanical energy) and oxygen consumption in cross-circulated excised dog hearts. However, nipradilol did not decrease total coronary resistance. These results indicate that nipradilol, like propranolol, depresses myocardial mechanoenergetics and that the vasodilating action of nipradilol could not be detected in the present study.</p>
キーワード cardiac mechanics cardiac energetics coronary circulation vertricle ?-blocker
Amo Type Article
発行日 1993-02
出版物タイトル Acta Medica Okayama
47巻
1号
出版者 Okayama University Medical School
開始ページ 29
終了ページ 33
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8096354
Web of Sience KeyUT A1993KP18500005