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ID 19786
Eprint ID
19786
フルテキストURL
Thumnail 68_1429.pdf 1.67 MB
タイトル(別表記)
Fundamental and Clinical Studies on Medical Treatment of Moniliasis with Photosensitizing Dyes. Part. Ⅱ Biological trials on Treatment of Moniliasis with Photosensitizing dye NK 91
著者
山口 義雄 岡山大学医学部平木内科教室
抄録
In vitro it was observed that NK 91 cxerted an excellent fungiostatic action against Candida albicans. So that, before clinical application, the author investigated about the fungiostatic action of NK 91 on experimental animals. The results were summarized as follows: 1) In the test of toxicity, mice which were given NK 91 subcutaneous injection over the certain quantity showed the symptoms of tachypnea and inactivity in the state of unrest and excitement and died finally. LD(50) in mice was 7.02 ± 0.38 mg/kg . 2) The hemolytic cation against the erythrocytes of rabbits occurred at the concentration of 5 γ / cc. It has been observed that the wandering velocity of neutrophils was moderate at the level of 1 γ / cc, slight accelerated at 10 γ / cc and slightly declined at 100 γ /cc. 3) The blood level of NK 91 in a non-oral administration maintained relatively high concentration in one to three hour, but declined rapidly with the lapse of time. 4) In respect of the protective test against the infection, it has been observed that the survival duration of experimental mice with Moniliasis were prolonged remarkably, compared with the control. 5) In therapeutic experiments, the author confirmed the remarkable decrease of Candida albicans in organs in the case treated with NK 91, compared with the control group in the case which was cultured from organs. Moreover, in the histologic investigations, the author observed the remarkable therapeutic effect in the treated group.
発行日
1956-09-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
68巻
9号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1429
終了ページ
1439
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/68/9/68_9_1429/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma