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ID 52010
JaLCDOI
フルテキストURL
Thumnail 67_6_369.pdf 2.64 MB
著者
Yu, Shaonan Department of Radiology, China-Japan Union Hospital, Jilin University
Wang, Xiaozhen Department of Cellular Biology, Health Science Center, Peking University
Liu, Guifeng Department of Radiology, China-Japan Union Hospital, Jilin University
Zhu, Xuewei Department of Otolaryngology Head&neck Surgery, China-Japan Union Hospital, Jilin University
Chen, Yan Department of Endocrinology, Second Hospital, Jilin University
抄録
Despite high sensitivity to chemotherapy, the prognosis for triple-negative breast cancer (TNBC) remains poor because of its high rate of metastasis and low sensitivity to endocrine therapy. CXCR4 expression has been reported in many subtypes of human breast cancers, but it remains unknown whether CXCR4 is expressed in TNBC and whether CXCR4 expression in TNBC could be a prognostic indicator. TNBCs tissues were formalin fixed, paraffin embedded and hematoxylin-eosin (H&E) stained. Immunohistochemical staining was utilized to determine the CXCR4 expression in those specimens. Statistical analyses were performed using SPSS16.0 software to reveal the correlation of CXCR4 expression in TNBC specimens and cancer recurrence and cancer-related death. Our results showed that there was a strong association between CXCR4 overexpression and both menopause and the histological cancer grade of TNBC patients (p values were separately 0.004 and 0.001). The 5-y disease-free survival (DFS) and the 5-y overall survival (OS) were 57.69% and 58.33% for the low-CXCR4 group versus 42.11% and 44.74% for the high-CXCR4 group, respectively (p=0.031 and 0.048). CXCR4 overexpression plays an important role in triple-negative breast cancers, and may be a predictor of poor prognosis.
キーワード
CXCR4
immunohistochemical staining
triple-negative breast cancer
Amo Type
Original Article
発行日
2013-12
出版物タイトル
Acta Medica Okayama
67巻
6号
出版者
Okayama University Medical School
開始ページ
369
終了ページ
375
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT