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ID 30787
JaLCDOI
フルテキストURL
著者
Mikami, Yuichirou Okayama University
Mizuno, Motowo Okayama University
Maga, Toshirou Okayama University
Kihara, Yasuhiro Okayama University
Yoshinaga, Fumiya Okayama University
Tanaka, Shouichi Okayama University
Yunoki, Naoko Okayama University
Kawahara, Toshiaki Okayama University
Okada, Hiroyuki Okayama University Kaken ID
Tsuji, Takao Okayama University
抄録

UDP-galactosyltransferase (UDP-Gal-T) is a key enzyme in the synthesis of mucus glycoprotein which plays an important role in gastric mucosal defensive mechanisms. Analysis of gastric UDP-Gal-T activity should clarify the mechanisms of the action of antiulcer drugs regarding gastric defensive factors. Here, we examined UDP-Gal-T activity in rat gastric mucosa treated with the antiulcer drugs geranylgeranylacetone (GGA) and cetraxate hydrochloride (CET). The effects of coadministration of indomethacin and exogenous administration of prostaglandins (PGs) were also studied. GGA and CET significantly increased UDP-Gal-T activity, and coadministration of indomethacin inhibited the increase of enzyme activity. UDP-Gal-T activity level with GGA was significantly higher than the control level, even in the presence of indomethacin. With CET, however, this was not the case. Among PGs, PGE1 significantly increased enzyme activity. Concomitant administration of PGE1 and GGA or CET increased UDP-Gal-T activity even with indomethacin to the levels achieved when these antiulcer drugs were administered without indomethacin. Our findings suggest that GGA and CET exert antiulcer effects by increasing mucus glycoprotein synthesis and that endogenous PG synthesis may be involved in this process. However, mechanisms not mediated by endogenous PGs may also exist in the stimulatory action of GGA on UDP-Gal-T activity.

キーワード
antiulcer drug
galactosyltransferase
prostaglandin
mucin
Amo Type
Article
発行日
1997-10
出版物タイトル
Acta Medica Okayama
51巻
5号
出版者
Okayama University Medical School
開始ページ
245
終了ページ
249
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT