JaLCDOI 10.18926/AMO/30761
フルテキストURL fulltext.pdf
著者 Mizobuchi, Noriko| Takahashi, Isao| Horimi, Tadashi| Yamamoto, Megumi| Hamada, Kyoko| Yorimitsu, Seiichi| Kubonishi, Ichiro|
抄録 <p>A new myeloid cell line, MTO-94, was established from the bone marrow of a patient with myelodysplastic syndrome (MDS). MTO-94 cells matured in culture medium without the addition of growth factors, and yielded neutrophils with pseudo-Pelger Hue&#776;t anomaly or hypersegmentation until 6 months. Ten months after the start of cell cultivation, MTO-94 consisted of myeloblasts. Surface phenotypes were as follows: CD7 90.3%, CD13 99.6%, CD33 75.6%, HLA-DR 96.3% and CD34 0.9%. The karyotype was 46, XY, i(17q). The proliferation of MTO-94 cells was enhanced by rhlL-3, G-CSF, rhGM-CSF and rhSCF but not by rhlL-6 and erythropoietin. MTO-94 cells with i(17q) might be useful in the study of biological aspects of not only MDS, but also hematological malignancies with i(17q) as the sole chromosomal anomaly.</p>
キーワード isochromosome 17q myeloid cell line myelodysplastic syndrome
Amo Type Article
発行日 1997-08
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 227
終了ページ 232
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9284971
Web of Sience KeyUT A1997XU03200007